Antibiotic Resistance in Bacterial Pathogens

Soto, Sara M.

doi:10.3390/antibiotics12030451

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…XDR was defined as nonsusceptibility to at least one agent in all but two or fewer antimicrobial categories listed and PDR was defined as non-susceptibility to all agents in all antimicrobial categories" according to the European Centre for Disease Control (ECDC) and the CDC (Alkofide et al 2020). The research community is focusing many efforts on the discovery of new antibiotics, the study of the mechanisms of resistance, epidemiology studies, the development of new tools for a rapid diagnostic of resistant bacteria and the study of the spread of AMR (Soto, 2023).…”

Section: Awarenessmentioning

confidence: 99%

Issue of Antibiotics Resistance: From Spot of One Health

2023

Egyptian Journal of Animal Health

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A ntibiotics were considered as an amazing gift to the human and animal healthcare sectors for the treatment of bacterial infections. Antibiotic resistance is the ability of bacteria to resist to the action of an antibiotic. Antimicrobial resistance is a worldwide problem. Antibacterial resistance results in a reduction or elimination of effectiveness of the antimicrobial agent to cure or prevent infection due to this microorganism. Macrolides resisted by gram-negative bacilli particularly members of the family Enterobacteriaceae (intrinsic resistance). Other bacteria like Staphylococci that are normally susceptible to antibiotics (penicillin) become resistant as a result of adaptation through genetic change (acquired resistance). All antibiotic-resistant bacteria survive in the presence of the antibiotic and continue to grow and multiply causing longer illness or even death. Multidrugresistant microorganism lies in the limited number of remaining options for therapy of patients infected with these microorganisms. The major cause of antimicrobial resistance in microorganisms from humans remains the use of antimicrobials in human medicine, in the community and in hospitals and other healthcare settings. The burden of antimicrobial resistance is mainly due to antimicrobials used in food-producing animals. The current review provides information about antibiotic resistance, its mechanisms responsible for the resistance, role of animal environment and foods of animal origin in spreading the threat and finally suggestions for controlling of antibiotics resistance.

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Section: Awarenessmentioning

confidence: 99%

Issue of Antibiotics Resistance: From Spot of One Health

2023

Egyptian Journal of Animal Health

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Analysing the Antibacterial Synergistic Interactions of Romanian Lavender Essential Oils via Gas Chromatography–Mass Spectrometry: In Vitro and In Silico Approaches

Bălașoiu (Jigău),

Obistioiu,

Hulea

et al. 2024

Plants

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This study investigated the phytochemical characteristics, antibacterial activity, and synergistic potential of essential oils derived from Romanian lavender. Gas Chromatography–Mass Spectrometry (GC/MS) analysis revealed that linalool is the main compound in all lavender essential oils, with concentrations ranging from 29.410% to 35.769%. Linalyl acetate was found in similar concentrations to linalool. Other significant compounds included 1,8-cineole (8.50%), lavandulyl acetate (5.38%), trans-β-ocimene (6.90%), and camphor (7.7%). A 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) test was used to assess antioxidant capacity, with substantial free-radical-scavenging activity shown in the IC50 values determined. The antibacterial efficacy of the oils was higher against Gram-positive bacteria than Gram-negative bacteria, with variations in minimum inhibitory concentrations (MICs), the extent of inhibition, and evolution patterns. The study also explored the oils’ ability to enhance the efficacy of ampicillin, revealing synergistic interactions expressed as fractional inhibitory concentration indices. In silico protein–ligand docking studies used twenty-one compounds identified by GC-MS with bacterial protein targets, showing notable binding interactions with SasG (−6.3 kcal/mol to −4.6 kcal/mol) and KAS III (−6.2 kcal/mol to −4.9 kcal/mol). Overall, the results indicate that Romanian lavender essential oils possess potent antioxidant and antibacterial properties, and their synergistic interaction with ampicillin has potential for enhancing antibiotic therapies.

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Antibiotic Resistance in Bacterial Pathogens

Abstract: The increasing number of infections caused by antibiotic-resistant bacterial pathogens over the last few decades has become a critical global health problem, the scale of which has led to it being named a “silent pandemic” [...]

Cited by 2 publications

References 14 publications

Issue of Antibiotics Resistance: From Spot of One Health

Issue of Antibiotics Resistance: From Spot of One Health

Analysing the Antibacterial Synergistic Interactions of Romanian Lavender Essential Oils via Gas Chromatography–Mass Spectrometry: In Vitro and In Silico Approaches

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