Antibiotic sensitivity of enteropathogenic bacteria isolated from patients in a Sharjah hospital

Abstract

SUMMARYIn recent years widespread circulation of salmonella and shigella strains resistant to multiple antibiotics has become an international problem. Accordingly the bacterial sensitivity to a range of antibiotics has been assessed in vitro and recorded for the period 1979-83 for patients from the Al Qassimi Hospital. A total of 229 enteric pathogens from 148 children and 59 adult patients were isolated and studied. Most of the enterobacteria were sensitive to colistin, gentamicin, trimethoprim and chloramphenicol (Salmonella typhi approached 1000 sensitivity).High rates of sensitivity were also found to ampicillin in S. typhi (96 00) and other salmonella serotypes (850%), whilst only 57 O% of Shigella species and 140% of Escherichia coli were sensitive to this antibiotic. Low rates of sensitivity to sulphamethoxazole, streptomycin and tetracycline were found in shigella and E. coli (ranging from 7 to 14%). Approximately 5000 of S. typhi and other salmonella serotypes were sensitive to sulphamethoxazole and streptomycin and 800 to tetracycline. Resistance to three or more antibiotics was very common in shigella and enteropathogenic strains of E. coli (74-850), less common in non-typhoid salmonella (290%) and exceptional in S. typhi strains. In general, shigella and E. coli isolates showed a high rate of resistance to several antibiotics, whilst S. typhi and other salmonella serotypes retained their original sensitivity to most of the antibiotics used in clinical practice.

In vitro activity of ceftazidime–avibactam, ceftolozane–tazobactam, and other comparable agents against clinically important Gram-negative bacilli: results from the 2017 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

“…The high colistin-NS rate was notably different from the rate of 17% calculated in an India-Arabian study investigating human NTS isolates. 27 However, a high mcr- 1-independent colistin-NS rate among NTS isolates was found to be related to intrinsic Pmr D overexpression. 28 , 29 In contrast, nanoarchitectural changes in capsular polysaccharides that increase capsule thickness and hardness following colistin exposure were observed for only a few K. pneumoniae isolates also displaying mcr- 1-independent colistin NS.…”

Insight into the Stunting vis a vis Salmonella and Shigella Species among Children of Pakistan

“…30.30%, this is in deviation from a study conducted in Al-Qasimi Hospital Sharjah, where Salmonella sp. have shown 100% sensitivity to gentamycin [33]. Moreover, this study has reported 80% susceptibility of Salmonella sp.…”