Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

Mardhia, Mardhia; Mahyarudin, Mahyarudin; Irsan, Abror

doi:10.5454/mi.14.3.1

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Antimicrobial resistance has the potential to affect people at every stage of life, involving various sectors such as the health Int J Public Health Sci ISSN: 2252-8806  industry, veterinary medicine, and agriculture [3]. Data in Pontianak and Surabaya, both in Indonesia, showed all urinary bacterial isolates had high resistance towards ampicillin and demonstrated multidrugs resistance [4], [5]. Data from global antimicrobial surveillance system also demonstrated an increased in antimicrobial resistance percentage in Indonesia [6].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia

Syahniar,

Farsida,

Kosasih

et al. 2024

IJPHS

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Abuse and overuse of antibiotics cause the increasing prevalence of antibiotic resistance. Doctors, nurses, midwives, and pharmacy professionals play an essential role in providing information and education on the use of antibiotics to the public. This study aims to compare and identify the factors that influence the knowledge and attitudes of students’ medicine, midwifery, pharmacy, and nursing toward antimicrobial resistance. An online crosssectional survey involving 530 medical, midwifery, pharmacy, and nursing students who are currently in the clinical or professional study stage. The Mann–Whitney U test and the Kruskal–Wallis test was run to assess differences in the mean scores of knowledges and attitudes. Factors related to knowledge and attitudes regarding antibiotic resistance were analyzed using linear regression. Most (93%) students have a good level of knowledge and have a positive attitude 49.81%, neutral 43.78%, and negative 6.41%. There was a relationship between age (p=0.012), major (p=0.000), source of information (p=0.013), and knowledge and attitudes about antibiotics (p<0.05). We conclude that there are differences in knowledge and attitudes toward antibiotic resistance among clinical-stage students of medicine, midwifery, pharmacy, and nursing. We found that essential knowledge and attitudes should be revised regarding antibiotic resistance.

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Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia

Syahniar,

Farsida,

Kosasih

et al. 2024

IJPHS

View full text Add to dashboard Cite

show abstract

“…During the last decade, evidence has emerged linking T2D to an increased risk of several infections ( 1 – 3 ), of which the most important are respiratory tract infections ( 4 , 5 ) including tuberculosis (TB), pneumonia and influenza ( 6 , 7 ). In addition to respiratory tract infections, diabetes is also associated with a 1.5-fold increased risk of surgical site infections ( 8 ), a 2-fold increased risk of urinary tract infections (UTIs) ( 9 ), and a 2-to 3-fold increased risk of bacteremia ( 10 ). This increased susceptibility is attributed to impairments in sentinel cells of the immune system, such as neutrophils ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy

et al. 2023

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Type 2-diabetes, particularly poorly controlled diabetes, is a risk factor for several infections such as lower respiratory tract and skin infections. Hyperglycemia, a characteristic downstream effect of poorly controlled diabetes, has been shown to impair the function of immune cells, in particular neutrophils. Several studies have demonstrated that hyperglycemia-mediated priming of NADPH oxidase results in subsequent elevated levels of reactive oxygen species (ROS). In healthy neutrophils, ROS plays an important role in pathogen killing by phagocytosis and by induction of Neutrophil Extracellular Traps (NETs). Given the key role of ROS in autophagy, phagocytosis and NETosis, the relationship between these pathways and the role of diabetes in the modulation of these pathways has not been explored previously. Therefore, our study aimed to understand the relationship between autophagy, phagocytosis and NETosis in diabetes. We hypothesized that hyperglycemia-associated oxidative stress alters the balance between phagocytosis and NETosis by modulating autophagy. Using whole blood samples from individuals with and without type 2-diabetes (in the presence and absence of hyperglycemia), we demonstrated that (i) hyperglycemia results in elevated levels of ROS in neutrophils from those with diabetes, (ii) elevated levels of ROS increase LCIII (a marker for autophagy) and downstream NETosis. (iii) Diabetes was also found to be associated with low levels of phagocytosis and phagocytic killing of S. pneumoniae. (iv) Blocking either NADPH oxidase or cellular pathways upstream of autophagy led to a significant reduction in NETosis. This study is the first to demonstrate the role of ROS in altering NETosis and phagocytosis by modulating autophagy in type 2-diabetes.

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Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

Cited by 2 publications

References 13 publications

Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia

Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia

Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy

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