Antibiotic Susceptibility Testing (Agar Disk Diffusion and Agar Dilution) of Clinical Isolates of &lt;i&gt;Corynebacterium jeikeium&lt;/i&gt;

Traub, Walter H.; Geipel, Udo; Leonhard, Birgit; Bauer, Dierk

doi:10.1159/000007119

Cited by 18 publications

(9 citation statements)

References 55 publications

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“…Another discord with earlier reports was revealed in case of TMP/SMX that was highly active on the majority of the strains studied by us while weak or missing activity of it against C. striatum, C. jeikeium, D. hominis and T. otitidis has been described [18][19][20]. Our results justify the role of TMP/SMX as the drug of choice for prostatitis in Canada [21].…”

Section: Mic (μG/ml)contrasting

confidence: 65%

Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen

Türk¹,

Punab²,

Mändar

2009

TOIDJ

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Abstract:Background: The susceptibility of coryneform bacteria has been studied mostly in invasive pathogens, less data are available concerning the mucosal or physiological fluid strains. At the same time they can serve as the source of various infections, besides the invasive infections also the local ones, for example, coryneforms of male genital tract have been associated with inflammatory prostatitis. Material and Methods:A total of 62 coryneform isolates from human semen were tested for susceptibility to eight antimicrobial agents using the E test method.Results: All strains were susceptible to ampicillin-sulbactam and only a few were resistant to penicillin G and TMP/SMX while nearly one third of strains were resistant or intermediate to doxycycline (35%) and norfloxacin (29%), and more than half to clindamycin (63%), nitrofurantoin (62%) and erythromycin (53%). The strains showing resistance to at least 3 antimicrobials belonged to Corynebacterium group F1, Corynebacterium seminale and Cellulomonas/Microbacterium sp. A distinct co-occurring macrolide and lincosamine resistance pattern was common.Conclusion: Ampicillin-sulbactam, penicillin G and TMP/SMX revealed the highest activity against coryneforms isolated from semen that were frequently resistant or intermediate to several other antimicrobials. Norfloxacin revealed only moderate activity against prostatitis-associated Corynebacterium group G.

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Section: Mic (μG/ml)contrasting

confidence: 65%

Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen

Türk¹,

Punab²,

Mändar

2009

TOIDJ

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“…Colonization of such indwelling devices as central venous catheters by C. jeikeium is a common problem among immunocompromised patients and may be associated with consecutive bacteremia and septic infections (7). Accordingly, C. jeikeium has already been considered as an opportunistic pathogen which easily acquires resistance to various antibiotic agents (19). In the present case, the changing antibiotic combinations over more than 2 weeks (from days Ϫ7 to ϩ8 [ Fig.…”

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confidence: 87%

Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient

et al. 2009

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Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic patient undergoing cord blood transplantation for secondary acute myeloid leukemia. CASE REPORTA 46-year-old man with an uneventful past medical history was diagnosed with acute lymphoblastic leukemia in early 2007. He received a first allogeneic stem cell transplant from a matched unrelated donor after successful induction and consolidation therapy. Early after transplantation, he presented with secondary acute myeloid leukemia and was induced with cyclophosphamide and clofarabine, leading to prolonged neutropenia. Without neutrophil recovery, he proceeded to a second allogeneic stem cell transplantation using a double cord blood source. Since vancomycin-resistant Enterococcus faecium (VRE) was detected in earlier stool samples of this patient, two further stool samples were taken after admission to the transplant unit and the presence of VRE was confirmed. Due to this finding, the prior systemic antibiotic chemotherapy and persistent neutropenia, and continuing fever, we treated the patient with a combination of ceftazidime and tigecycline (Fig. 1).After conditioning chemotherapy was initiated, the antibiotic treatment was changed to meropenem and fosfomycin due to recurring febrile temperatures. While fever continued for 2 days, three blood cultures taken on day Ϫ6 (before the second transplant) were found to be positive for vancomycin-sensitive E. faecium and Staphylococcus haemolyticus. As both isolates showed susceptibility to daptomycin, the antibiotic regimen was changed to daptomycin and ceftazidime (Fig. 1). The patient recovered from febrile temperatures and received a double cord blood allograft on day 0 (8 January 2008). Blood cultures taken from each of the four central venous catheter lines on days Ϫ1 and ϩ1 remained sterile. The clinical course was again complicated on day ϩ3 by increasing C-reactive protein (CRP) levels and fever. The antibiotic regimen was therefore changed to meropenem, fosfomycin, and ciprofloxacin, leading to a short-term decrease of CRP levels and clinical symptoms.Due to recurrent febrile temperatures, the past infectious history, and positive results for gram-positive rods in two out of four blood cultures taken on day ϩ5, fosfomycin was substituted for daptomycin on day ϩ8. Four further aerobic and anaerobic blood cultures, taken on day ϩ8 and incubated at 37°C in a BacT/Alert 3D instrument (bioMérieux, Marcy-l'-Etoile, France), were found to be positive for gram-positive rods after 24 h of cultivation. Subculture testing for another 24 h at 37°C in a 5% CO 2 -enriched atmosphere revealed small, gray, catalase-positive colonies on chocolate and blood agar. The organism was subsequently identified as Corynebacterium jeikeium (P ϭ 0.963) by using an API Coryne V3.0 kit (bioMérieux, ...

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“…Antimicrobial susceptibility studies revealed that a preponderant proportion of the reported C. jeikeium isolates are substantially multiresistant against clinically relevant antibiotics and that only glycopeptides, such as vancomycin and teicoplanin, remain universally active against this species (4,38,79). This emergence of multiresistant phenotypes largely limits the therapeutic options and has thus tremendous consequences for successful treatment of C. jeikeium infections, especially in immunocompromised patients.…”

mentioning

confidence: 99%

Complete Genome Sequence and Analysis of the Multiresistant Nosocomial PathogenCorynebacterium jeikeiumK411, a Lipid-Requiring Bacterium of the Human Skin Flora

et al. 2005

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Corynebacterium jeikeium is a "lipophilic" and multidrug-resistant bacterial species of the human skin flora that has been recognized with increasing frequency as a serious nosocomial pathogen. Here we report the genome sequence of the clinical isolate C. jeikeium K411, which was initially recovered from the axilla of a bone marrow transplant patient. The genome of C. jeikeium K411 consists of a circular chromosome of 2,462,499 bp and the 14,323-bp bacteriocin-producing plasmid pKW4. The chromosome of C. jeikeium K411 contains 2,104 predicted coding sequences, 52% of which were considered to be orthologous with genes in the Corynebacterium glutamicum, Corynebacterium efficiens, and Corynebacterium diphtheriae genomes. These genes apparently represent the chromosomal backbone that is conserved between the four corynebacteria. Among the genes that lack an ortholog in the known corynebacterial genomes, many are located close to transposable elements or revealed an atypical G؉C content, indicating that horizontal gene transfer played an important role in the acquisition of genes involved in iron and manganese homeostasis, in multidrug resistance, in bacterium-host interaction, and in virulence. Metabolic analyses of the genome sequence indicated that the "lipophilic" phenotype of C. jeikeium most likely originates from the absence of fatty acid synthase and thus represents a fatty acid auxotrophy. Accordingly, both the complete gene repertoire and the deduced lifestyle of C. jeikeium K411 largely reflect the strict dependence of growth on the presence of exogenous fatty acids. The predicted virulence factors of C. jeikeium K411 are apparently involved in ensuring the availability of exogenous fatty acids by damaging the host tissue.

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Antibiotic Susceptibility Testing (Agar Disk Diffusion and Agar Dilution) of Clinical Isolates of <i>Corynebacterium jeikeium</i>

Cited by 18 publications

References 55 publications

Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen

Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen

Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient

Complete Genome Sequence and Analysis of the Multiresistant Nosocomial PathogenCorynebacterium jeikeiumK411, a Lipid-Requiring Bacterium of the Human Skin Flora

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