Antibiotic Use in Finfish Aquaculture: Modes of Action, Environmental Fate, and Microbial Resistance

Armstrong, S. M.; Hargrave, B. T.; Haya, K.

doi:10.1007/b136017

Cited by 37 publications

(63 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the end of this period, fish were subjected to antibiotic treatment: commercial trout diets (Skretting, UK: Excel diet) were top dressed with oxolinic acid (Vetrepharm Ltd., Fordingbridge, UK) according to the manufacturer’s instructions (20 mg kg −1 , fed daily over 10‐day period). Oxolinic acid is commonly used for the treatment of Gram‐negative bacterial pathogens (Armstrong et al. 2005).…”

Section: Methodsmentioning

confidence: 99%

“…Due to the current limitations and regulations on the use of antimicrobials in animal nutrition antibiotics are no longer used as therapeutics or growth promoters within the European Union (Regulation 1831/2003/EC). However, they are still an important part of the arsenal of treatments for many salmonid bacterial diseases and are routinely used worldwide for treatment of bacterial infections (Armstrong et al. 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Probiotic applications for rainbow trout (Oncorhynchus mykiss Walbaum) II. Effects on growth performance, feed utilization, intestinal microbiota and related health criteria postantibiotic treatment

Merrifield

Bradley

Baker

et al. 2010

Aquaculture Nutrition

214

124

View full text Add to dashboard Cite

The effect of dietary probiotics (Bacillus subtilis, Bacillus licheniformis and Enterococcus faecium) was assessed on rainbow trout (Oncorhynchus mykiss Walbaum) previously treated with oxolinic acid. After feeding on supplemented diets for 10 weeks growth performance, feed utilization, gastrointestinal colonization and health status were assessed. B. subtilis + B. licheniformis fed fish displayed a significant improvement of feed conversation ration (FCR), specific growth rate (SGR) and protein efficiency ratio (PER). High levels of probiotic species were observed in the posterior gastrointestinal tract as transient digesta associated populations and potentially resident mucosal populations. Levels of Bacillus spp. reached log 3.74 CFU g−1 on the mucosal epithelium and log 7.41 CFU g−1 in the digesta of fish fed diets supplemented with B. subtilis and B. licheniformis. Enterococci levels reached log 2.84 CFU g−1 on the mucosa and log 7.78 CFU g−1 in the digesta of fish fed E. faecium supplemented diets. Feeding trout the Bacillus probionts alone or synergistically with E. faecium resulted in elevated leucocyte levels. The results of the current study demonstrate a potential role of probiotics for stabilizing/reinforcing the gastrointestinal microbiota after antibiotic treatment. This could reinvigorate the intestinal defensive barrier mechanism and provide protection against secondary potential pathogens.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Probiotic applications for rainbow trout (Oncorhynchus mykiss Walbaum) II. Effects on growth performance, feed utilization, intestinal microbiota and related health criteria postantibiotic treatment

Merrifield

Bradley

Baker

et al. 2010

Aquaculture Nutrition

214

124

View full text Add to dashboard Cite

show abstract

“…These include Aeromonas salmonicida , A. hydrophila , A. caviae , A. sobria , E. ictaluri , E. tarda , P. damselae piscicida , Vibrio anguillarum, V. salmonicida , V. ordalii , Flavobacterium psychrophilum , Pseudomonas fluorescens, Streptococcus iniae , Renibacterium salmonicarum , Yersinia ruckeri and Piscirickettsia salmonis (Table ). In most of them, antimicrobial resistance is mediated by plasmids and MGE, often conjugative, and with potential for HGT (Austin, ; Arthur et al ., ; Rhodes et al ., ; Sørum, 2000; 2008; Schmidt et al ., 2001a; Armstrong et al ., ; Casas et al ., ; Toranzo et al ., ; Erauso et al ., ). Some of these pathogens, e.g.…”

Section: Effects Of Aquacultural Use Of Antimicrobials On Animal and mentioning

confidence: 98%

Antimicrobial use in aquaculture re‐examined: its relevance to antimicrobial resistance and to animal and human health

Cabello

Godfrey

Tomova

et al. 2013

Environmental Microbiology

698

515

View full text Add to dashboard Cite

SummaryThe worldwide growth of aquaculture has been accompanied by a rapid increase in therapeutic and prophylactic usage of antimicrobials including those important in human therapeutics. Approximately 80% of antimicrobials used in aquaculture enter the environment with their activity intact where they select for bacteria whose resistance arises from mutations or more importantly, from mobile genetic elements containing multiple resistance determinants transmissible to other bacteria. Such selection alters biodiversity in aquatic environments and the normal flora of fish and shellfish. The commonality of the mobilome (the total of all mobile genetic elements in a genome) between aquatic and terrestrial bacteria together with the presence of residual antimicrobials, biofilms, and high concentrations of bacteriophages where the aquatic environment may also be contaminated with pathogens of human and animal origin can stimulate exchange of genetic information between aquatic and terrestrial bacteria. Several recently found genetic elements and resistance determinants for quinolones, tetracyclines, and b-lactamases are shared between aquatic bacteria, fish pathogens, and human pathogens, and appear to have originated in aquatic bacteria. Excessive use of antimicrobials in aquaculture can thus potentially negatively impact animal and human health as well as the aquatic environment and should be better assessed and regulated.

show abstract

“…The β-lactam antibiotics (amoxicillin) occur naturally in the environment and should undergo oxidation via biological and physicochemical pathways (Armstrong et al, 2005). However, it has been argued that antibacterial agents such as antibiotics resist microbial degradation in sediment, but are mainly eliminated by washing out (Samuelsen, 1989) or other mechanisms including abiotic photolysis and hydrolysis (Pouliquen et al, 2007).…”

Section: Chemotherapeutantsmentioning

confidence: 99%

Measurement of Aquaculture Chemotherapeutants in Flocculent Matter Collected at a Hard-Bottom Dominated Finfish Site on the South Coast of Newfoundland (Canada) After 2 Years of Fallow

et al. 2018

View full text Add to dashboard Cite

The expansion of aquaculture is resulting in sites being installed over a diversity of substrate types, leading to different potential chemotherapeutant degradation scenarios. There is little to no information on the biodegradation and/or persistence of chemotherapeutants at hard-bottom dominated aquaculture sites having little natural sediment. In this study, we measured organic matter (OM) content and concentrations of chemicals linked to finfish aquaculture activities (trace elements, antibiotics and parasiticides) in flocculent matter samples collected close to cages at a site fallowed for 2 years and at an active site, the latter being indicative of flocculent chemical signature during production. Our results show persistence of flocculent matter after 2 years of fallow. The chemical signature of the samples confirms that Cu, Zn, Ca, and P, present around fish cages, are direct markers of aquaculture wastes. Persistence of two pyrethroids, one avermectin, and one antibiotic in grab samples show a potentially lasting association between these chemicals and the OM from fish feed and wastes, even after 2 years. Overall, the concentrations measured do not indicate a direct lethal toxicity on marine organisms (as per studies described in literature) except for Zn. Nevertheless, the long-term persistence of a flocculent mixture rich in chemicals and the lack of information on sublethal and synergistic effects on hard-bottom communities calls for caution and additional studies.

show abstract

Antibiotic Use in Finfish Aquaculture: Modes of Action, Environmental Fate, and Microbial Resistance

Cited by 37 publications

References 40 publications

Probiotic applications for rainbow trout (Oncorhynchus mykiss Walbaum) II. Effects on growth performance, feed utilization, intestinal microbiota and related health criteria postantibiotic treatment

Probiotic applications for rainbow trout (Oncorhynchus mykiss Walbaum) II. Effects on growth performance, feed utilization, intestinal microbiota and related health criteria postantibiotic treatment

Antimicrobial use in aquaculture re‐examined: its relevance to antimicrobial resistance and to animal and human health

Measurement of Aquaculture Chemotherapeutants in Flocculent Matter Collected at a Hard-Bottom Dominated Finfish Site on the South Coast of Newfoundland (Canada) After 2 Years of Fallow

Contact Info

Product

Resources

About