Antibiotics in veterinary medicine and public health

Pérez-Trallero, Emilio; Urbieta, Mercedes; Lopategui, CarmenL.; Zigorraga, Carmen; Ayestaran, Isabel

doi:10.1016/0140-6736(93)92285-2

Cited by 15 publications

(4 citation statements)

References 4 publications

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“…Enrofloxacin is given to chickens and turkeys by adding it to drinking water, thereby administering it to tens of thousands of birds at once (i.e., on a housewide basis). Several investigations have demonstrated that the use of enrofloxacin in poultry results in the rapid emergence of ciprofloxacin resistance among Campylobacter species in poultry [21][22][23][24][25]. The FDA conducted a quantitative risk assessment that concluded that the use of fluoroquinolone agents in poultry resulted in the emergence and dissemination of ciprofloxacin-resistant Campylobacter species, which are transmitted to humans through the food supply.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Diarrhea Due to Ciprofloxacin‐ResistantCampylobacterInfection

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Prolonged Diarrhea Due to Ciprofloxacin‐ResistantCampylobacterInfection

et al. 2004

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“…Fluoroquinolones are one of the best choices for treating these kinds of infections in adults (13,22). However, treatment failures related to reduced ciprofloxacin susceptibility that developed during quinolone treatment have been described (19,27). These treatment failures and the finding of mutations in the gyrA gene of all the nalidixic acidresistant isolates studied suggest that a reduction in fluoroquinolone MIC breakpoints for Salmonella should be advised (1).…”

Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Quinolone Resistance in Human Nontyphoid Salmonella enterica Isolates Obtained in Spain from 1981 to 2003

Marimón

Gomariz

Zigorraga

et al. 2004

Antimicrob Agents Chemother

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nalidixic acid was tested in 10,504 nontyphoid Salmonella enterica isolates from patients with acute enteric disease in Gipuzkoa, Spain. The prevalence of nalidixic acid resistance steadily increased from less than 0.5% before 1991 to 38.5% in 2003, mainly due to the increase in resistance among isolates of the most prevalent serovar, S. enterica serovar Enteritidis. For nalidixic acid-resistant isolates, the ciprofloxacin MIC was eightfold higher than that for susceptible isolates, and the nalidixic acid-resistant isolates contained a single point mutation in the gyrA gene (at codons for Ser83 or Asp87). The same mutations were found in a sample of nalidixic acid-resistant nontyphoid Salmonella strains isolated between 1999 and 2003 from retail food for human consumption. In 2003, we identified five S. enterica serovar Typhimurium clinical isolates with high-level fluoroquinolone resistance (ciprofloxacin MIC, 16 g/ml) with two point mutations in the gyrA gene (coding for Ser833Phe and Asp873Asn) and one point mutation in the parC gene (coding for Ser803Arg). Strict sanitary controls are needed to avoid the spread of ciprofloxacin-resistant serovar Typhimurium isolates, and a more efficient veterinary policy must be adopted to decrease the large burden of Salmonella serovar Enteritidis infections in humans in our region.

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“…Although the cost of administration of fluoroquinolones to farm animals is supposedly prohibitive (30), they are undoubtedly in widespread use in parts of Europe (11a, 17). There is pressure to limit the use of these agents in animals to preserve their value in the treatment of human infections (6,15,18,21).…”

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confidence: 99%

Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals

Griggs

Gensberg

Piddock

1996

Antimicrob Agents Chemother

159

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The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are associated with quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require revision.

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Antibiotics in veterinary medicine and public health

Cited by 15 publications

References 4 publications

Prolonged Diarrhea Due to Ciprofloxacin‐ResistantCampylobacterInfection

Prolonged Diarrhea Due to Ciprofloxacin‐ResistantCampylobacterInfection

Increasing Prevalence of Quinolone Resistance in Human Nontyphoid Salmonella enterica Isolates Obtained in Spain from 1981 to 2003

Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals

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