Antibodies Inside Our Keratinocytes?

Clinicopathological evaluation ofin vivoepidermal nuclear fluorescence

“…A second hypothesis is binding of autoantibodies to antigens on keratinocyte surface with posterior internalization. Our data (eight patients with negative serum ANA at the time of biopsy) corroborate those of previous investigators, 4,10,11,15 suggesting that autoantibodies, when penetrating living cells, compromise cellular homeostasis and may lead to cell apoptosis 12 …”