Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Ranki, Annamari; Kurki, Pekka; Riepponen, Senja; Stephansson, Eija

doi:10.1002/art.1780351212

Cited by 58 publications

(16 citation statements)

References 45 publications

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“…This is in accordance with previous findings of correlations of anti-RNP (38,56) and of antiretroviral antibodies (18,30) with disease activity in patients with SLE and overlap syndromes. This is particularly interesting in view of a recent observation linking apoptosis to disease activity in SLE.…”

Section: Discussionsupporting

confidence: 94%

“…Involvement of retroviral elements in the triggering of autoimmunity has been suspected based on the discovery of I) cross-reactive antibodies to gag (13,1618), env (19,20), and nefproteins (18) of human retroviruses in patients with autoimmune disease (21)(22)(23), and 2) autoimmunity syndromes in patients infected by human retroviruses (24). Amino acid sequence similarities between certain nonhuman retroviral g a g proteins and human autoantigens, (U 1)snRNP (25), topoisomerase I (26), and La (27) have suggested the possibility that the natural targets of cross-reactive antibodies in patients with autoimmune disease may correspond to endogenous retroviruses (ERV).…”

Section: Hres-1 Antibodies In Autoimmune Disease 1661mentioning

confidence: 99%

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Antibody reactivity to the hres‐1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes

Perl

Colombo

Dai

et al. 1995

Arthritis & Rheumatism

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Objective. To evaluate the correlation between the presence of antibodies to an endogenous retroviral element-encoded nuclear protein autoantigen, HRES-1, and the presence of other antinuclear antibodies and HLA class I1 alleles in patients with systemic lupus erythematosus (SLE) and overlap syndromes.Methods. Antibody reactivities to native and recombinant proteins and synthetic peptides were assessed by counterimmunoelectrophoresis, enzyme-linked immunosorbent assay, and Western blotting. HLA class I1 alleles were determined by oligonucleotide typing.Results. significant association between anti-HRES-1 and anti-RNP and an inverse correlation between HRES-1 and RolLa autoantibodies in patients with SLE or overlap syndromes. Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar ArgILys residues, represent cross-reactive epitopes between the two proteins. Selective removal of HRES-1 antibodies from sera of HRES-l-seropositive/RNP-seropositive patients by absorption on recombinant HRES-l/glutathione-Stransferase-conjugated agarose beads had no effect on anti-RNP reactivities. A comparative multivariate analysis of HLA class I1 genes revealed a differential segregation of DQBl alleles in HRES-l-seropositive versus HRES-1-seronegative patients (P = 0.04). While a relative increase of DQB1*0402 among HRES-1-seropositive patients was noted across ethnic groups (P = 0.02), a decrease of DQB1*0201 and DQB1*0301 was found in white HRES-l-seropositive patients (P = 0.04).Conclusion. Autoantibodies to HRES-1 are detectable in a distinct subset of patients with autoimmune disease, primarily in those who do not have antibodies to Ro and La. Anti-HRES-1 and anti-RNP reactivities are mediated by cross-reactive but separate antibody molecules. HLA-DQB genes, rather than HLA-DRB or DQA genes, may have a more significant influence on generation of these antinuclear autoantibodies.A hallmark of the destructive autoimmune process in patients with systemic lupus erythematosus

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Section: Discussionsupporting

confidence: 94%

Section: Hres-1 Antibodies In Autoimmune Disease 1661mentioning

confidence: 99%

Antibody reactivity to the hres‐1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes

Perl

Colombo

Dai

et al. 1995

Arthritis & Rheumatism

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“…Antibodies reactive with HIV or HTLV Gag (CA, p24) are common in patients with autoimmune diseases such as MS, SS, and SLE (369,407,477,478). In general, anti-Env antibodies are not present in these individuals, although sera from patients with mixed connective tissue disease are reported to contain neutralizing antibodies that block HIV infection (127).…”

Section: Detection Of Serum Antibodies To Retrovirusesmentioning

confidence: 99%

Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease

Voisset

Weiss

Griffiths

2008

Microbiol Mol Biol Rev

145

156

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SUMMARY Retroviruses are an important group of pathogens that cause a variety of diseases in humans and animals. Four human retroviruses are currently known, including human immunodeficiency virus type 1, which causes AIDS, and human T-lymphotropic virus type 1, which causes cancer and inflammatory disease. For many years, there have been sporadic reports of additional human retroviral infections, particularly in cancer and other chronic diseases. Unfortunately, many of these putative viruses remain unproven and controversial, and some retrovirologists have dismissed them as merely “human rumor viruses.” Work in this field was last reviewed in depth in 1984, and since then, the molecular techniques available for identifying and characterizing retroviruses have improved enormously in sensitivity. The advent of PCR in particular has dramatically enhanced our ability to detect novel viral sequences in human tissues. However, DNA amplification techniques have also increased the potential for false-positive detection due to contamination. In addition, the presence of many families of human endogenous retroviruses (HERVs) within our DNA can obstruct attempts to identify and validate novel human retroviruses. Here, we aim to bring together the data on “novel” retroviral infections in humans by critically examining the evidence for those putative viruses that have been linked with disease and the likelihood that they represent genuine human infections. We provide a background to the field and a discussion of potential confounding factors along with some technical guidelines. In addition, some of the difficulties associated with obtaining formal proof of causation for common or ubiquitous agents such as HERVs are discussed.

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“…There are various patients who may have a falsepositive HIV-1 result by EIA and/or an indeterminate western blot result, including those who have received blood products or who have circulating antibodies related to another condition such as an autoimmune disease [3]. Indeed, circulating immune complexes have been detected in adult patients receiving hemodialysis [4].…”

Section: Introductionmentioning

confidence: 98%

False-positive human immunodeficiency virus antibody test in a dialysis patient

2004

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A patient developed end-stage renal disease secondary to p-anti-neutrophil cytoplasmic antibody (p-ANCA) positive rapidly progressive glomerulonephritis. He subsequently had human immunodeficiency virus (HIV)-1 antibody screening performed as part of a pre-transplant evaluation. The HIV-1 enzyme immunoassay (EIA) antibody test was repeatedly reactive. The HIV-1 western blot was indeterminate. The western blot pattern revealed "non-specific staining obscuring bands in that region." Another sample of serum was sent and the results were identical to the first result. An HIV-1 proviral qualitative polymerase chain reaction test was then performed several months later and no HIV-1 DNA was detected. One year later, an HIV-1 RNA test was negative. Thus, the positive antibody EIA test and the indeterminate western blot represent a false-positive result, most likely due to cross-reacting antigens in the patient's serum with various HIV antibodies. Throughout this period and thereafter, the patient has exhibited no symptoms of HIV infection.

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Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Cited by 58 publications

References 45 publications

Antibody reactivity to the hres‐1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes

Antibody reactivity to the hres‐1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes

Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease

False-positive human immunodeficiency virus antibody test in a dialysis patient

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