Antibody affinity and immune complexes after immunization with tetanus toxoid in protein-energy malnutrition

Chandra, Ranjit Kumar; Chandra, S.; Gupta, Sheena

doi:10.1093/ajcn/40.1.131

Cited by 38 publications

(21 citation statements)

References 5 publications

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“…Consistent with the ®ndings in adults, malnutrition has adverse effects on immune function in children, affecting both cellular and humoral defence mechanisms, polymorphonuclear leukocyte activity and complement activity (Teitell-Cohen et al, 1980;Salimonu et al, 1983;Chandra et al, 1984;Spurr et al, 1984;Ramirez et al, 1985).…”

Section: Nutritional Status As a Determinant Of Outcomesupporting

confidence: 60%

Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral de®ciencies are all common following transplantation and have profound nutritional consequences. Malnutrition affects negatively the clinical outcome. Nutritional support is provided to malnourished patients and those who suffer deterioration in nutritional status despite the provision of dietetic counselling. Only a few randomised studies comparing enteral with parenteral nutrition after transplant exist. Both enteral tube feeding (in the absence of mucositis) and parenteral nutrition are effective in maintaining nutritional status. However, enteral nutrition is associated with a better nutritional response and fewer complications than parenteral. With existing enteral and parenteral nutrition regimens close monitoring of trace element and mineral status is required.

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Section: Nutritional Status As a Determinant Of Outcomesupporting

confidence: 60%

Nutritional considerations in children undergoing bone marrow transplantation

Papadopoulou

1998

Eur J Clin Nutr

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“…To our knowledge, only one previous study has examined the association of malnutrition with antibody avidity following vaccination. This study determined that infants with marasmus or kwashiorkor had significantly lower antibody avidity following tetanus vaccination than did well-nourished infants (46). Future studies examining the impact of interventions for stunting on antibody quantity and avidity maturation appear to be warranted.…”

Section: Discussionmentioning

confidence: 88%

Effect of Multivitamin Supplementation on Measles Vaccine Response among HIV-Exposed Uninfected Tanzanian Infants

Sudfeld

Duggan

Histed

et al. 2013

Clin Vaccine Immunol

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Immunization and nutritional interventions are mainstays of child health programs in sub-Saharan Africa, yet few published data exist on their interactions. HIV-exposed (but uninfected) infants enrolled in a randomized placebo-controlled trial of multivitamin supplements (vitamins B complex, C, and E) conducted in Tanzania were sampled for an assessment of measles IgG quantity and avidity at 15 to 18 months. Infants were vaccinated between 8.5 and 12 months of age, and all mothers received high-dose multivitamins as the standard of care. Of 201 HIV-exposed infants who were enrolled, 138 (68.7%) were seropositive for measles. There were no effects of infant multivitamin supplementation on measles seroconversion proportions, IgG concentrations, or IgG avidity (P > 0.05). The measles seroconversion proportion was greater for HIV-exposed infants vaccinated at 10 to 11 months of age than for those vaccinated at 8.5 to 10 months (P ‫؍‬ 0.032) and greater for infants whose mothers had a CD4 T-cell count of <200 cells/l than for infants whose mothers had a CD4 T-cell count of >350 cells/l (P ‫؍‬ 0.039). Stunted infants had a significantly decreased IgG quantity compared to nonstunted infants (P ‫؍‬ 0.012). As for measles avidity, HIV-exposed infants vaccinated at 10 to 11 months had increased antibody avidity compared to those vaccinated at 8.5 to 10 months (P ‫؍‬ 0.031). Maternal CD4 T-cell counts of <200 cells/l were associated with decreased avidity compared to counts of >350 cells/l (P ‫؍‬ 0.047), as were lower infant height-for-age z-scores (P ‫؍‬ 0.016). Supplementation with multivitamins containing B complex, C, and E does not appear to improve measles vaccine responses for HIV-exposed infants. Studies are needed to better characterize the impact of maternal HIV disease severity on the immune system development of HIV-exposed infants and the effect of malnutrition interventions on vaccine responses. (This study has been registered at ClinicalTrials.gov under registration no. NCT00197730.)

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“…Other studies have suggested that reduced T-cell number and their function are responsible for the impairment of protective immunity against M. tuberculosis (27)(28)(29). In human subjects, most of the findings regarding vaccine-induced immunity and nutritional state are controversial (12,30,31), and these have not been addressed using a new vaccine method. In this study, we focused on DNA vaccination and carried out experiments using an animal model since a DNA vaccine has recently been developed and used in human clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Protein Deficiency Impairs DNA Vaccine-Induced Antigen-Specific T Cell but Not B Cell Response in C57BL/6 Mice

Sakai

Mitsuya

Kogiso

et al. 2006

J Nutr Sci Vitaminol

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Summary DNA vaccination is a simple method to induce antigen (Ag)-specific immunoresponse and has many potential advantages over other vaccines. Although people who need to receive vaccines often suffer undernutrition, there has been no study on a how nutritional status affects the immunoresponse induced by DNA vaccination. The aim of this study was to determine the relationship between protein deficiency and DNA vaccineinduced immunoresponses. C57BL/6 mice were fed a 5% or 20% casein diet for 30 d. The mice were immunized with an ovalubumin (OVA)-expression plasmid by the gene gunbased method three times at 10-d intervals. Body weight and serum albumin concentration in protein-deficient mice were significantly lower than those in mice fed the 20% casein diet ( p Ͻ 0.01, p Ͻ 0.05). The percentage of OVA-specific CD8 ϩ T cells was significantly decreased in the 5% casein group compared to that in the 20% casein group ( p Ͻ 0.05). Furthermore, CD4 ϩ T cells from mice fed the low-protein diet showed lower interleukin (IL)-2 production than did those from the 20% group. In contrast to the T-cell function, protein deficiency did not affect OVA-specific Ab responses ( p Ͼ 0.05). These results suggest that protein deficiency impairs the induction of Ag-specific T-cell but not B-cell response in DNA-immunized mice. Our observation indicates that, in addition to development of an effective of DNA vaccine, the management of nutritional state is important for the prevention of infectious disease by DNA vaccination.

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Antibody affinity and immune complexes after immunization with tetanus toxoid in protein-energy malnutrition

Cited by 38 publications

References 5 publications

Nutritional considerations in children undergoing bone marrow transplantation

Nutritional considerations in children undergoing bone marrow transplantation

Effect of Multivitamin Supplementation on Measles Vaccine Response among HIV-Exposed Uninfected Tanzanian Infants

Protein Deficiency Impairs DNA Vaccine-Induced Antigen-Specific T Cell but Not B Cell Response in C57BL/6 Mice

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