Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy

Zlamy, M; Goegele, C; Schönlaub, Jörn; Würzner, Reinhard; Holzmann, Heidemarie; Zimmerhackl, L. B.; Prelog, Martina

doi:10.1055/s-0030-1261299

Cited by 4 publications

(5 citation statements)

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“…However, besides the challenges of the interpretation of avidity data, usage of NH 4 SCN appears to be sufficient to assess the binding strength between antibody and antigen and seems to be easily applied in an adapted ELISA system. Interestingly, urea treatment did not work in our experimental setting, although it was successfully applied in assessing avidities of IgG antibodies directed against other antigens of infectious agents (Kneitz et al, 2004;Zachou et al, 2006;Ozkul et al, 2008;Hedman et al, 2010;Zlamy et al, 2010). However, in view of these data, the success of each dissociating agent in interrupting the antibodyantigen binding seems to be highly dependent on the kind of investigated antigen and its specific antibodies.…”

Section: Discussionmentioning

confidence: 91%

Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate

Almanzar

Ottensmeier

Liese

et al. 2013

Journal of Immunological Methods

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Section: Discussionmentioning

confidence: 91%

Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate

Almanzar

Ottensmeier

Liese

et al. 2013

Journal of Immunological Methods

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“…19 Several studies found that multiple immune alterations arose in humans whose thymus gland was removed in early childhood as a result of surgery for congenital heart diseases, and the removal of the thymus may result in a delayed immune response to new antigens later in life. [20][21][22][23] Zlamy et al 24 revealed that early thymectomy in childhood demonstrated immunological alterations of CD8 + T cells, which mimic features of premature immunosenescence in humans. MG patients with a long term after thymectomy had mild T cell lymphopenia, and also displayed a polyclonal increase in serum IgG and IgM associated with the presence of some antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…In experimental animals, neonatal thymectomy has been reported to lead to various degrees of T cell depletion 19 . Several studies found that multiple immune alterations arose in humans whose thymus gland was removed in early childhood as a result of surgery for congenital heart diseases, and the removal of the thymus may result in a delayed immune response to new antigens later in life 20–23 . Zlamy et al 24 revealed that early thymectomy in childhood demonstrated immunological alterations of CD8 + T cells, which mimic features of premature immunosenescence in humans.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of myasthenia gravis (MG) patients developing other autoimmune diseases after thymectomy from one single center cohort

Tian

et al. 2022

Thoracic Cancer

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Background Myasthenia gravis (MG) patients are reported to have a high risk of other autoimmune diseases (ADs), and thymectomy may increase the risk further. A cohort of MG patients in which thymectomy was performed were investigated to analyze the prevalence, types and features of the new onset ADs. Methods Consecutive patients with MG who underwent thymectomy at Beijing Hospital between January 2012 and August 2021 were retrospectively enrolled. Patients with a postoperative follow‐up period shorter than a year or incomplete clinical records were excluded. Clinical and follow‐up data were collected. Statistical analyses were performed using SPSS version 22.0. Results A total of 445 patients were included in this study. The median follow‐up period was 72 months (range, 12–135 months). A total of 63 (14.2%) MG patients had concurrent ADs. The incidence rate was higher than the background prevalence of population (5%), and also higher than that of a former Chinese MG cohort (11.6%). A total of 47 patients (10.6%) were diagnosed with ADs before thymectomy, and 19 (4.3%) developed a new AD after thymectomy. The most common types of new onset ADs after thymectomy were Hashimoto's thyroiditis and rheumatoid arthritis (RA), which were different from those before thymectomy (hyperthyroidism and Hashimoto's thyroiditis). The incidence rate of new onset RA (1.35%) was higher than the frequency of RA before thymectomy (0.45%), and also higher than the incidence rate in a Chinese MG cohort (0.5%). There was a higher proportion of female patients (p = 0.026) with postoperative ADs. A younger age at operation may increase the risk of nonthymoma MG patients (p = 0.040) developing ADs. The postoperative treatment effect of MG was similar between patients with and without new onset ADs (p > 0.05). Conclusions We observed a higher incidence rate of autoimmune diseases, especially rheumatoid arthritis, in MG patients after thymectomy. The most common types of ADs after thymectomy were different from those before thymectomy. New onset ADs tended to occur in female and young nonthymoma MG patients. The postoperative effect of MG was not related with the new occurrence of ADs.

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“…After thymectomy in infancy because of open heart surgery, children showed a delayed immune response to new antigens such as tick-bone encephalitis-vaccine. 55 At time, no studies concerning influence of thymectomy on immune response to vaccination particularly in very young children with JMG are present. The question of immunological side effects after thymectomy during early childhood is still to be discussed.…”

Section: Surgical Treatmentmentioning

confidence: 99%

Juvenile Myasthenia Gravis: Recommendations for Diagnostic Approaches and Treatment

Marina¹,

Trippe²,

Lutz³

et al. 2014

Neuropediatrics

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Juvenile myasthenia gravis (JMG) is an autoimmune disorder of neuromuscular transmission caused by production of antibodies against components of the postsynaptic membrane of the neuromuscular junction. Ethnicity has influence on incidence, clinical presentation, and the course of the disease. The patients present with a wide range of symptoms?from isolated intermittent ocular symptoms to general muscle weakness with or without respiratory insufficiency. Compared with adults and adolescents, the clinical signs and course of disease in children exhibit differences and occasionally untypical symptoms. Therefore, JMG is often missed and the diagnosis delayed. Isolated ocular symptoms are frequent at onset, spontaneous remission or intermittent symptoms over the longer period of time can occur. Very young children may present with generalized muscle weakness already during the second year of life and in this patient group, specific antibodies can only be slightly increased or even negative. Existing therapeutic options include immunosuppressive therapy and thymectomy but potential long-term side effects on the growing organism and possible influence on immune response in very young children should be considered. Specific clinical symptoms, diagnostic procedures, and a therapeutic approach with consideration of this age group's specificities are discussed.

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Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy

Cited by 4 publications

References 0 publications

Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate

Assessment of IgG avidity against pertussis toxin and filamentous hemagglutinin via an adapted enzyme-linked immunosorbent assay (ELISA) using ammonium thiocyanate

Clinical characteristics of myasthenia gravis (MG) patients developing other autoimmune diseases after thymectomy from one single center cohort

Juvenile Myasthenia Gravis: Recommendations for Diagnostic Approaches and Treatment

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