Anticancer activities of toxic isolate of Xestospongia testudinaria sponge

Swantara, Made Dira; Rita, Wiwik Susanah; Suartha, I Nyoman; Agustina, Kadek Karang

doi:10.14202/vetworld.2019.1434-1440

Cited by 37 publications

(21 citation statements)

References 35 publications

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“…Phytol-inhibited cell proliferation and promoted autophagy in MCF-7 and human gastric adenocarcinoma AGS cells [ 37 ]. Other constituents observed were stigmasterol chemopreventive activity in cancer [ 38 ], Ergost-5-en-3-ol [anti-cancer in gastric, lung, and ovarian cancer [ [39] , [40] , [41] , [42] ]], 3,7,11,15-Tetramethyl-2-hexadecen-1-ol [anti-cancer [ 43 ]], 9-Octadecenoic acid, 1,2,3-propanetriyl ester, (E,E,E)-compound (cytotoxic on human epidermoid larynx carcinoma (Hep-2) cell line) [ 44 ], stigmast-4-en-3-one [anti-cancer effect on the MG-63 cell line [ 45 ]].…”

Section: Discussionmentioning

confidence: 99%

Unveiling antioxidant and anti-cancer potentials of characterized Annona reticulata leaf extract in 1,2-dimethylhydrazine-induced colorectal cancer in Wistar rats

Kumar

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background Colorectal cancer (CC) is the third most common cancer in the world. Annona reticulata (AR) also known as bullock's heart, is a traditional herb. AR leaf extract was initially investigated for its anti-bacterial, anti-inflammatory, anti-malarial, anti-helminthic, anti-stress, and wound healing properties. Only a few in vitro cancer studies have been conducted on AR. Although few studies have linked AR leaf extract to many cancers, comprehensive studies addressing regulation, biological functions, and molecular mechanisms leading to CC pathogenesis are clearly lacking. Objectives The present study aimed to explore the antioxidant and anti-cancer potentials of AR leaf extract in CC. Materials and methods The MTT assay was used to test the anti-proliferative activity of AR leaf extract in vitro on the HCT116 cell line. Qualitative and quantitative phytochemical characterization was carried out using gas chromatography: mass spectrometry (GC–MS). 1,2-dimethylhydrazine (DMH) was used to establish CC model in female Wistar rats. The acute toxicity of AR leaf extract was tested in accordance with OECD guidelines. Aberrant Crypt Foci (ACF) count, organ index, and hematological estimations were used to screen for in vivo anti-cancer potential. The antioxidant activity of colon homogenate was determined. Results The alcoholic leaf extract (IC50, 0.55 μg/ml) was found to be more potent than the aqueous extract. Using GC–MS, a total of 108 compounds were quantified in the alcoholic leaf extract. The LD 50 value was found to be safe at a dose of 98.11 mg/kg of body weight. AR alcoholic leaf extract significantly (p < 0.05) decreased ACF count and normalized colon length/weight ratio. AR leaf extract increased RBC, hemoglobin and platelets levels. The AR alcoholic leaf extract reduced the DMH-induced tumors and significantly (p < 0.05) increased the activity of endogenous antioxidant enzymes such as catalase, reduced glutathione, superoxide dismutase, and decreased the lipid peroxidase activity. AR leaf extract reduced the inflammation caused by DMH and helped to repair the colon's damaged muscle layers. Conclusion Based on the findings from the present study, it can be concluded that the alcoholic leaf extract of AR has antioxidant and anti-proliferative properties and can aid in the prevention of CC development and dysplasia caused by DMH.

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Section: Discussionmentioning

confidence: 99%

Unveiling antioxidant and anti-cancer potentials of characterized Annona reticulata leaf extract in 1,2-dimethylhydrazine-induced colorectal cancer in Wistar rats

Kumar

et al. 2021

Journal of Ayurveda and Integrative Medicine

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“…Benzothiazole is a bicyclic ring system with multiple applications such as anti-diabetic, analgesic, anti-convulsant, anti-inflammatory, anti-malarial, anti-microbial, anti-thelmintic and antitumour activities (Gill et al, 2015). 4,8,12,16-Tetramethylheptadecan-4-olide is a possible source of vitamin E (Rontani et al, 2007), and has antimicrobial activity (Osama et al, 2017) and anti-breast cancer properties, as reported by Swantara et al (2019) in a study investigating the volatile compounds of the sponge Xestospongia testudinaria against HeLa cancer cells. The study demonstrates the significance of 4,8,12,16-Tetramethylheptadecan-4-olide as a possible anticancer drug, which was synthesised in this study by fungal endophytes Aureobasidium pullulans, Paracamarosporium leucadendri, Cladosporium sp., Fusarium sp., Hyalodendriella sp., Penicillium chrysogenum, Penicillium chrysogenum and Talaromyces sp.…”

Section: Comparison Of Volatile Metabolites Harvested In Winter and Summermentioning

confidence: 96%

“…The study demonstrates the significance of 4,8,12,16-Tetramethylheptadecan-4-olide as a possible anticancer drug, which was synthesised in this study by fungal endophytes Aureobasidium pullulans, Paracamarosporium leucadendri, Cladosporium sp., Fusarium sp., Hyalodendriella sp., Penicillium chrysogenum, Penicillium chrysogenum and Talaromyces sp. (Swantara et al, 2019).…”

Section: Comparison Of Volatile Metabolites Harvested In Winter and Summermentioning

confidence: 99%

Chemotaxonomic profiling of fungal endophytes of Solanum mauritianum (alien weed) using gas chromatography high resolution time-of-flight mass spectrometry (GC-HRTOF-MS)

2021

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Introduction Since ancient times medicinal plants have been used as medicine in many parts of the world to promote human health and longevity. In recent years many novel secondary metabolites of plants have been isolated and reported to provide lead compounds for new drug discoveries. Solanum mauritianum Scopoli is native to South America. It is reported to be used by native South Americans during famine as a vegetable and as medicine to cure various diseases. In South Africa the plant is viewed as weed and is facing eradication, however, this plant is a valuable subject for research into its potential pharmaceutical and chemical uses. This study elucidated the metabolic profile of fungal endophytes that have promising bioactive secondary metabolites against pathogenic microorganisms, including mycobacterium species. Material and methods Fungal endophytes from a weed Solanum mauritianum Scop. were used to synthesize secondary metabolites. Gas chromatograph high-resolution time-of-flight mass spectrometry (GC-HRTOF-MS) was used to analyse volatile compounds to prove that potentially fungal endophytes could be extracted from this weed. Extracts obtained with ethyl acetate were screened for phytochemicals and analyzed using a gas chromatograph high-resolution time-of-flight mass spectrometry system. Principal component analysis was used to compare the gas chromatograph high-resolution time-of-flight mass spectrometry data for differences/similarities in their clustering. Phytochemical screening was conducted on the crude extracts of fungal endophytes obtained from different parts of Solanum mauritianum Scopoli (leaves, ripe fruit, unripe fruit and stems). Results Phytochemical screening indicated the presents of alkaloids, flavonoids, glycosides, phenols, quinones and saponins. Quinones were not present in the crude extracts of Fusarium sp. A total of 991 compounds were observed in the fungal endophytes, and Cladosporium sp. (23.8%) had the highest number of compounds, compared to Paracamarosporium leucadendri (1.7%) and Talaromyces sp. (1.5%). Some volatile compounds such as eicosane, 2-pentadecanone, 2-methyloctacosane, hexacosane and tridecanoic acid methyl ester with antibacterial activity were also observed. Conclusion Compositional variations between the plant and fungal endophyte phytochemicals were observed. The results of this study indicate that fungal endophytes from Solanum mauritianum Scop. contain compounds that can be exploited for numerous pharmaceutical and medicinal applications.

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“…Tercatat hampir 5000 senyawa telah diisolasi dari spons dan berefek sebagai antikanker (Swantara et al, 2019). Salah satu jenis spons yang berpotensi sebagai sumber dari senyawa yang bersifat antikanker adalah spons yang berasal dari genus Xestospongia.…”

Section: Pendahuluanunclassified

“…Ekstrak kloroformnya adalah yang paling toksik dengan Nilai LC50 39,81 ppm. Fraksi yang paling beracun dengan LC50 yaitu 44,67 ppm (<1000 ppm, sehingga dilanjutkan ke uji terhadap sel HeLa sebagai uji antikanker) dengan uji MTT(Microtetrazolium) untuk mengukur proliferasi sel berdasarkanpengurangan garam tetrazolium kuning MTT, yang direduksi menjadi kristal formazan ungu oleh mitokondria (Swantara et al, 2019).…”

Section: Hasil Dan Pembahasan a Potensi Spons Sebagai Antikankerunclassified

Review Artikel : Aktivitas Antikanker dari Spons Laut Genus Xestospongia

Fristiohady¹

2021

PMJ

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The discovery of novel agents in the treatment of cancer is still being conducted, one of them is by developing the marine natural resources as an anti-cancer drug. Sponges like the genus Xestospongia, are natural marine resources that have potential as anti-cancer. Thus,, this review aims to showing the potential of the genus Xestospongia as an anticancer. This review was carried out by collecting the literature from various databases from 2014 to 2019. Results obtained that marin sponge Xestospongia, including Xestospongia testudinaria, Xestospongia exigua, Xestospongia muta and Xestospongiawiedemayeri, were used as anticancer. These compounds such as Quinolizidine, Aragusterol, Araguspic and many more.Keywords— Xestospongia, anticancer, cytotoxicity Abstrak Penemuan obat baru dalam pengobatan kanker masih intensif dilakukan, salah satunya dengan pengembangan sumber daya alam laut sebagai obat anti kanker. Spons seperti genus Xestospongia, merupakan sumber daya alam laut yang memiliki potensi sebagai anti kanker. Oleh karena itu, review ini bertujuan untuk menunjukkan potensispons genus Xestospongia sebagai antikanker. Review ini dilakukan dengan mengumpulkan pustaka dari berbagai database dari tahun 2014 hingga 2019. Hasil yang didapatkan bahwa spesies dari Xestospongia seperti Xestospongia testudinaria, Xestospongia exigua, Xestospongia muta dan Xestospongia wiedemayeri tercatat berpotensi sebagai antikanker. Senyawa-senyawa tersebut seperti Quinolizidine, Aragusterol, Araguspic dan masih banyak lagi.Kata Kunci— Xestospongia, antikanker, sitotoksisitas

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Anticancer activities of toxic isolate of Xestospongia testudinaria sponge

Cited by 37 publications

References 35 publications

Unveiling antioxidant and anti-cancer potentials of characterized Annona reticulata leaf extract in 1,2-dimethylhydrazine-induced colorectal cancer in Wistar rats

Unveiling antioxidant and anti-cancer potentials of characterized Annona reticulata leaf extract in 1,2-dimethylhydrazine-induced colorectal cancer in Wistar rats

Chemotaxonomic profiling of fungal endophytes of Solanum mauritianum (alien weed) using gas chromatography high resolution time-of-flight mass spectrometry (GC-HRTOF-MS)

Review Artikel : Aktivitas Antikanker dari Spons Laut Genus Xestospongia

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