Anticancer Activity against Brain Cancer Using Ni (II), Cu (II), Pd (II) and Au (III) Complexes Derived from Novel Mannich Base

Abstract

New four metal ion complexes of Ni(II), Cu(II), Pd(II) and Au(III) were derived from the tridentate ligand 3-((3-(4-hydroxyphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)amino)benzofuran-2(3H)-one (L), which synthesized using condensation reaction of formaldehyde, acetone and secondary amine (Mannich reaction). The secondary amine is a heterocyclic compound possesses two rings. The structures of the new compounds and metal ion complexes were characterized using elemental analysis (C.H.N.S), FT-IR, UV-Vis spectroscopy, thermal gravimetric analysis (TGA), flame atomic absorption, molar conductivity and magnetic susceptibility measurements. Accordingly, the probable geometries of these complexes were suggested as square planner and all complexes were found to be of electrolytic nature. Thus, chemical formula; [NiLCl] Cl.6H2O, [CuLCl]Cl.H2O, [PdLCl]Cl.2H2O and [AuLCl]Cl2.3H2O. Cytotoxic effect studding was applied onbrain cancer cell line (AMJM) at using the MMT method for complexes and L. Gold (III) complex has the highest cytotoxicity among all tested compounds.