Anticancer activity and metabolic profile alterations by ortho‐topolin riboside in in vitro and in vivo models of non‐small cell lung cancer

Lee, Hwanhui; Kwon, Yeo‐Jung; Jin, Hanyong; Liu, Heifeng; Kang, Wonku; Chun, Young‐Jin; Bae, Jang–Ho; Choi, Hyung‐Kyoon

doi:10.1096/fj.202101333r

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Cytoprotection1

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2024

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Cited by 1 publication

(2 citation statements)

References 67 publications

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“…Based on the data on the cytoprotective activity of the structurally similar compounds [5,19,22,23], we tested the synthesized compounds in two antioxidant models (protection against the H2O2 and CoCl2 cytotoxicity) in a 24-hour incubation.…”

Section: Cytoprotectionmentioning

confidence: 99%

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Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents

Oshchepkov,

Kovalenko,

Kalistratova

et al. 2024

Preprint

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Natural cytokinins are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of novel cytokinin analogs with alkyl substituents at various positions of the aromatic moiety, as well as with oxygen-containing groups, and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Two amino-linked compounds were anti-proliferative with the ability to act synergistically with doxorubicin, and two carbamate-based ones were cytoprotective. According to the molecular docking data, anti-proliferation was based on the A2AR and APRT inhibition and cytoprotection on the CDK2 inhibition. The obtained results are promising for the development of novel anti-cancer therapeutics.

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Section: Cytoprotectionmentioning

confidence: 99%

“…Plant-isolated compounds [1], such as flavonoids [2][3][4] and phytohormones, as well as their synthetic analogs [5][6][7][8][9] are considered to be very promising as potential anti-cancer agents.…”

Section: Introductionmentioning

confidence: 99%