Anticancer activity for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and Their abilities to interact with lymphoendothelial cell surface markers

Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment

“…Coumarins are a group of compounds that play important roles as food constituents, antioxidants, stabilizers and immunomodulatory substances, as fluorescent markers for use in analyses, in stains, and in clinical use for their [2,3] diuretic [4], anti-coagulant, anti-cancer [2], anti-HIV [5], antitumor [6], anti-inflammatory [7], anti-Alzheimer's [8], anti-leukemic [9,10], antibacterial [11], anti-malarial activities [12], emetic [13], and anti-anaphylactic activities [14]. Moreover, they can also be employed as cosmetics and pigments [13] and utilized as potential biodegradable agrochemicals [15].…”

<strong>CATALYSIS INVESTIGATION FOR SYNTHESIS OF 2-AMINO-4<em>H</em>-PYRAN-3-CARBONITRILES CONTAINING PROPARGYL GROUP</strong>

“…Propargyl acetoacetate (3) was prepared in our lab from 2,2,6-trimethyl-1,3-dioxen-4-one (1) and propargyl alcohol (2) in large scale with yield of 73% (Scheme 1, top). A series of different substituted propargyl 6-amino-5-cyano-2-methyl-4-aryl-4H-pyran-3-carboxylates ((5a-f)) were synthesized from propargyl acetoacetate (3) by three-component reaction with malononitrile and corresponding substituted benzaldehydes (4a-l) (Scheme 1, bottom).…”

“…4H-pyran derivatives well distributed in many naturally occurring compounds [1]. Organic compounds containing 4H-pyran ring shown biologically activities, such as antimicrobial [2], anti-inflammatory [3], anticancer [4], etc…The synthesis of some propargylic ethers of 2-amino-4H-chromene-3-carbonitriles was reported in our previous paper [5] from resorcinol, malononitrile and benzaldehydes by three-component one-pot reaction. In continuation of our work, herein a green approach for the one pot synthesis of propargyl ester of 2-amino-3-cyano-4H-pyran derivatives has been reported.…”

K2CO3: A Mild and Efficient Catalyst for the Synthesis of Pyran Annulated Heterocyclic Systems by Grinding Method Under Solvent-Free Conditions

“…4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent an outstanding structural motif well distributed in naturally occurring compounds [3][4][5] with a broad spectrum of considerable biological activities that embrace antimicrobial, 6 anti-inflammatory, 7 antihyperglycemic and antidyslipidemic, 8 anti-HIV [9][10][11] and antimalarial 12,13 .…”