Anticancer activity of functional polysuccinates with N-acetyl-cysteine in side chains

Mrówka, Maciej; Jaszcz, Katarzyna; Skonieczna, Magdalena

doi:10.1016/j.ejphar.2020.173501

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…In turn, improving mechanical properties enables the use of such materials in modern, innovative, and unusual solutions [8][9][10]. An important aspect of new materials is their environmental nontoxicity, which includes both the impact of the material itself and its possible degradation products [11].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

et al. 2021

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Silicones are often used for various types of coatings, but due to their poor mechanical properties, they often require modification to meet specific requirements. At the same time, various production processes throughout the world generate different types of waste, the disposal of which is harmful to the environment. One possible solution is to use production waste as a filler. In this paper, the authors investigated how the use of metallurgical production waste products as fillers changed the mechanical properties of silicone composites prepared by casting. Composite samples were characterized using tensile tests, resilience, pin-on-disc, Schopper–Schlobach abrasion, hardness, and density measurements. Based on the obtained results, the authors assessed the effect of each of the fillers used in different weight proportions. The results showed that the silicone composite filled with 5 wt% zinc dust showed the lowest decrease in tensile strength and Young’s modulus, with a simultaneous significant reduction in abrasion compared with the reference sample. This research shows that zinc waste can be successfully introduced into a silicone matrix in cases where it is important to reduce abrasive wear.

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Section: Introductionmentioning

confidence: 99%

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

et al. 2021

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“…The cytotoxicity of the tested composites was obtained according to the standard procedures against model cell lines [29,30,32]. The viability and proliferation assays, such as an MTT assay, allowed for biocompatibility of different, natural, or synthetic agents assessments [32,33].…”

Section: Cytotoxicity Test Resultsmentioning

confidence: 99%

“…Cytotoxicity testing of composite samples according to the procedure described earlier [29,30]. Cell viability of normal human dermal fibroblasts (NHDF, Lonza) was assessed using an MTT (3-[4-5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) test.…”

Section: Cytotoxicity Testing Of Composite Samplesmentioning

confidence: 99%

The Impact of Wood Waste on the Properties of Silicone-Based Composites

2020

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The impact of wood waste on the mechanical and biological properties of silicone-based composites was investigated using wood waste from oak, hornbeam, beech, and spruce trees. The density, abrasion resistance, resilience, hardness, and static tensile properties of the obtained WPC (wood–plastic composites) were tested. The results revealed slight changes in the density, increased abrasion resistance, decreased resilience, increased hardness, and decreased strain at break and stress at break compared with untreated silicone. The samples also showed no cytotoxicity to normal human dermal fibroblast, NHDF. The possibility of using prepared composites as materials to create structures on the seabed was also investigated by placing samples in a marine aquarium for one week and then observing sea algae growth.

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“…Choosing the right filler can increase mechanical strength and reduce abrasion at the same time [ 11 , 12 ]. An important aspect of the new materials is their non-toxicity to the environment, understood as both the impact of the entire material and that of products of possible degradation [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical, Chemical, and Processing Properties of Specimens Manufactured from Poly-Ether-Ether-Ketone (PEEK) Using 3D Printing

et al. 2021

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As part of the experiments herein, the mechanical properties of specimens made of poly-ether-ether-ketone (PEEK) material using 3D printing technology were determined. Two populations of specimens were investigated, the first of which contained an amorphous structure, while the other held a crystal structure. The studies also investigated the influence of the print directionality on the mechanical properties obtained. Static tensile, three-point bending, and impact tests were carried out. The results for the effect of the structure type on the tensile properties showed that the modulus of elasticity was approximately 20% higher for the crystal than for the amorphous PEEK form. The Poisson’s ratios were similar, but the ratio was slightly higher for the amorphous samples than the crystalline ones. Furthermore, the studies included a chemical PEEK modification to increase the hydrophilicity. For this purpose, nitrite and hydroxyl groups were introduced into the chain by chemical reactions. The results demonstrate that the modified PEEK specimens had worse thermoplastic properties than the unmodified specimens.

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Anticancer activity of functional polysuccinates with N-acetyl-cysteine in side chains

Cited by 9 publications

References 25 publications

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

The Influence of Zinc Waste Filler on the Tribological and Mechanical Properties of Silicone-Based Composites

The Impact of Wood Waste on the Properties of Silicone-Based Composites

Mechanical, Chemical, and Processing Properties of Specimens Manufactured from Poly-Ether-Ether-Ketone (PEEK) Using 3D Printing

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