Anticancer activity of lanthanum (III) and europium (III) 5‐fluorouracil complexes on Caco‐2 cell line

El‐Maali, Nagwa Abo; Wahman, Asmaa Y.; Aly, Aref A. M.; Nassar, Ahmed; Sayed, Douaa

doi:10.1002/aoc.5594

Cited by 13 publications

(2 citation statements)

References 43 publications

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“…A La(III)-5-fluorouracil complex (1:1 molar ratio) was synthesized and tested against the Caco-2 cell line (trypan blue exclusion assay). The presence of the La(III) coordination center significantly improved cytotoxicity, compared to 5-fluorouracil [ 128 ]. Molecular docking studies suggested interaction with site II of BSA.…”

Section: Novel Metal Complexes In Cancer Therapymentioning

confidence: 99%

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Todorov

Kostova

2023

Molecules

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Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining traction. The authors of the present review article aim to help the reader “catch up” with some of the latest developments in the vast subject of coordination compounds in oncology. Herewith is offered a review of the published scientific literature on anticancer coordination compounds of Pt, Ru, Au, Ga and La that has been released over the past three years with the hope readers find the following article informative and helpful.

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Section: Novel Metal Complexes In Cancer Therapymentioning

confidence: 99%

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Todorov

Kostova

2023

Molecules

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“…The complexes of rare-earth ions have aroused much interest. Lanthanide ions are the subject of increasing interest in bioinorganic and coordination chemistry 20,21 . Literature studies showed that complexes of lanthanides are associated with several biological properties such as cytotoxic effect and anticancer effect 19,[22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

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Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4- 4b) were synthesized using lanthanum nitrate hexahydrate (La(NO 3 ).6H 2 O) and nickel dichloride hexahydrate (NiCl 2 .6H 2 O). The synthesized complexes 5a-d were isolated and characterized by IR, Mass, and 1 HNMR spectroscopy. The spectra of complexes 5a-d were interpreted on the basis of comparison with the spectrum of the free ligand. These complexes were screened for DNA photocleavage activity. Two complexes, 5a, and 5b, gave significantly good results found to degrade both forms of DNA (SC and NC). Our data give the reason to conclude that these compounds can act as lead compounds and should be submitted to further more detailed biological evaluation.

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DNA Interactions, Antimicrobial, In Vitro Cytotoxicity, Molecular Docking, Cell Cycle Analysis, and Apoptosis Assay Efficiency of Newly Nano‐Sized Tridentate Cu(II), Ni(II), Pd(II), and Pt(II) Chelates of (E)‐5‐Fluoro‐2‐(((5‐(2‐fluorophenyl)‐furan‐2‐yl)methylene)amino)benzenethiol

Siddiq,

Mousa,

Alenazy

et al. 2024

Applied Organom Chemis

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Nano‐sized tridentate transition metal(II) chelates, specifically [M(FONS)Cl] with H‐FONS = ligand and M = Cu(II) (C1), Ni(II) (C2), Pd(II) (C3), and Pt(II) (C4), underwent synthesis and subsequent characterization. The HOMO–LUMO energy gaps (ΔE) were used to create theoretical models for the structure and confirmation barriers in molecular systems for the ligand (H‐FONS) and metal chelates. It was found that the Cu(II), Ni(II), Pd(II), and Pt(II) chelates have lower values for HOMO–LUMO energy gaps (ΔE), indicating that they are more stable than the H‐FONS 1igand.The metal formed four coordinated with the tridentate NOS donor Schiff base to form square‐planar geometry chelates. The results of TEM, EDX, AFM, and x‐ray diffraction calculations for the bivalent metal chelates indicated sharp and intense diffraction peaks, confirming their crystalline nature and nanoscale particle size. The interaction between calf thymus DNA (CT‐DNA) and the chelates was examined utilizing the UV–Vis spectroscopic method, revealing their capacity to bind with CT‐DNA via intercalation mode. Nano‐sized metal(II) chelates show a higher viscous nature than H‐FONS. The cytotoxicity of H‐FONS and its metal(II) chelates in nano form against the liver cancer cell line (HepG2) was evaluated by studying in vitro cell proliferation using the MTT assay. The findings demonstrated that all compounds exhibited anticancer properties, displaying a dose‐dependent response. Our flow cytometry data indicate significant levels of cell cycle arrest in the liver cancer cell line. By molecular docking study, it was found that the Cu(II) chelate (C1) showed the highest and better binding affinity (−8.2 and −8.7 kcal/mol) than other 1igand (H‐FONS) and comp1exes (C2–C4) for the BCL2 and PBP3 proteins central activities.

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Anticancer activity of lanthanum (III) and europium (III) 5‐fluorouracil complexes on Caco‐2 cell line

Cited by 13 publications

References 43 publications

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

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