Anticancer agents based on metal organic cages

Sun, Demei; Feng, Xuesong; Zhu, Xinyuan; Wang, Youfu; Yang, Jinghui

doi:10.1016/j.ccr.2023.215546

Cited by 12 publications

(8 citation statements)

References 119 publications

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“…In fact, the field is rapidly advancing, with progress in many therapeutic contexts. However, the biomedical applications of molecular cages are still in their infancy [61][62][63][64][65]. In the context of drug delivery, molecular cages can play a pivotal role as protective systems from the surrounding media, increasing drug stability [66,67].…”

Section: Biological Applicationsmentioning

confidence: 99%

Water-Soluble Molecular Cages for Biological Applications

Montà-González,

Ortiz-Gómez,

López-Lima

et al. 2024

Molecules

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The field of molecular cages has attracted increasing interest in relation to the development of biological applications, as evidenced by the remarkable examples published in recent years. Two key factors have contributed to this achievement: First, the remarkable and adjustable host–guest chemical properties of molecular cages make them highly suitable for biological applications. This allows encapsulating therapeutic molecules to improve their properties. Second, significant advances have been made in synthetic methods to create water-soluble molecular cages. Achieving the necessary water solubility is a significant challenge, which in most cases requires specific chemical groups to overcome the inherent hydrophobic nature of the molecular cages which feature the organic components of the cage. This can be achieved by either incorporating water-solubilizing groups with negative/positive charges, polyethylene glycol chains, etc.; or by introducing charges directly into the cage structure itself. These synthetic strategies allow preparing water-soluble molecular cages for diverse biological applications, including cages’ anticancer activity, anticancer drug delivery, photodynamic therapy, and molecular recognition of biological molecules. In the review we describe selected examples that show the main concepts to achieve water solubility in molecular cages and some selected recent biological applications.

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Section: Biological Applicationsmentioning

confidence: 99%

Water-Soluble Molecular Cages for Biological Applications

Montà-González,

Ortiz-Gómez,

López-Lima

et al. 2024

Molecules

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“…19,20 In fact, a variety of delicate MOC-based nanoagents or nanocarriers for different biological applications have been developed that demonstrate outstanding performances. 21–23…”

Section: Introductionmentioning

confidence: 99%

A biocompatible Mn-decorated metal–organic cage with sustainable CO release

Ning,

Yin,

Zhang

et al. 2024

New J. Chem.

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“…These materials exhibit exceptional properties and functionalities, making them highly versatile for a wide range of applications. 11,12,18–20 The stable, adjustable, and nanoscale structures, porousness, and biocompatibility of MOCs confer significant advantages and potential as nanozymes. 21 However, at this stage, limited research has been conducted on the utilization of MOCs as nanozymes with antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%