1987
DOI: 10.1038/bjc.1987.33
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Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro

Abstract: Summary During recent years N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been developed as targetable drug carriers. These soluble synthetic polymers are internalized by cells by pinocytosis and they can be tailor-made to include peptidyl side-chains degradable intracellularly by specific lysosomal enzymes. Thus they provide the opportunity fo achieve controlled intracellular delivery of anticancer agents. The anthracycline antibiotic daunomycin, and protein synthesis inhibitor puromycin, were boun… Show more

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Cited by 166 publications
(72 citation statements)
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“…Fractions corresponding to the isomers were collected and analyzed by TOF-MS spectrum. Their structure were confirmed by one-and two-dimensional NMR ( 1 H, 13 C, 1 H, 1 H COSY, 1 H, 13 C HMQC). The yields of trans-ADOX and cis-ADOX were 44.8 and 36.3%, respectively.…”
Section: Synthesis Of Aconityl-doxorubicinmentioning
confidence: 80%
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“…Fractions corresponding to the isomers were collected and analyzed by TOF-MS spectrum. Their structure were confirmed by one-and two-dimensional NMR ( 1 H, 13 C, 1 H, 1 H COSY, 1 H, 13 C HMQC). The yields of trans-ADOX and cis-ADOX were 44.8 and 36.3%, respectively.…”
Section: Synthesis Of Aconityl-doxorubicinmentioning
confidence: 80%
“…These products were separated completely by using HPLC (Fig. 2) and were analyzed by TOF-MS spectroscopy and one-and two-dimensional NMR ( 1 H, 13 spectroscopy and 1 H-and 13 C-NMR experiments. 32) ADOX was bound to PVA according to the synthetic scheme shown in Fig.…”
Section: Discussionmentioning
confidence: 99%
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