Anticancer agents from marine sponges

Ye, Jianjun; Zhou, Feng; Al-Kareef, Ammar M Q; Wang, Hong

doi:10.1080/10286020.2014.970535

Cited by 34 publications

(23 citation statements)

References 53 publications

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“…Besides the importance of the Q/HQ couple as anticancer agents [ 7 , 8 , 9 , 10 ] antifungal [ 11 , 12 ], and antiparasitic drugs [ 13 ], the quinone motif is also found in many dangerous xenobiotics, such as carcinogenic polyaromatic quinones generated in air-suspended particulate by oxidation of polycyclic aromatic hydrocarbons [ 14 ]. During the last years, Q/HQ derivatives have also gained growing interest in the development of new organic materials, in areas such as solar energy conversion, [ 15 ] organic switches for molecular electronics, [ 16 ] organic light-emitting diodes (OLEDs) [ 16 , 17 ] and batteries [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones

et al. 2017

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The rational design of quinones with specific redox properties is an issue of great interest because of their applications in pharmaceutical and material sciences. In this work, the electrochemical behavior of a series of four p-quinones was studied experimentally and theoretically. The first and second one-electron reduction potentials of the quinones were determined using cyclic voltammetry and correlated with those calculated by density functional theory (DFT) using three different functionals, BHandHLYP, M06-2x and PBE0. The differences among the experimental reduction potentials were explained in terms of structural effects on the stabilities of the formed species. DFT calculations accurately reproduced the first one-electron experimental reduction potentials with R2 higher than 0.94. The BHandHLYP functional presented the best fit to the experimental values (R2 = 0.957), followed by M06-2x (R2 = 0.947) and PBE0 (R2 = 0.942).

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Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones

et al. 2017

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“…Marine sponges have served as one of the most productive sources of anticancer substances in marine environment 10 . As a part of our discovery of new anticancer agents from natural resources, we have been trying to search molecular-targeted antitumor lead compounds from marine sponges 11 12 13 14 .…”

mentioning

confidence: 99%

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

Wang

Zhang

Peng

et al. 2016

Sci Rep

132

115

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Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel compounds with various activities. We isolated stellettin B (Stel B) from marine sponge Jaspis stellifera, and demonstrated that it induced G1 arrest, apoptosis and autophagy at low concentrations in human NSCLC A549 cells. G1 arrest by Stel B might be attributed to the reduction of cyclin D1 and enhancement of p27 expression. The apoptosis induction might be related to the cleavage of PARP and increase of ROS generation. Moreover, we demonstrated that Stel B induced autophagy in A549 cells by use of various assays including monodansylcadaverine (MDC) staining, transmission electron microscopy (TEM), tandem mRFP-GFP-LC3 fluorescence microscopy, and western blot detection of the autophagy markers of LC3B, p62 and Atg5. Meanwhile, Stel B inhibited the expression of PI3K-p110, and the phosphorylation of PDK1, Akt, mTOR, p70S6K as well as GSK-3β, suggesting the correlation of blocking PI3K/Akt/mTOR pathway with the above antitumor activities. Together, our findings indicate the antitumor potential of Stel B for NSCLC by targeting PI3K/Akt/mTOR pathway.

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“…Approximately 30.000 macromolecules isolated from these niches have already been discovered and catalogued, however, these data correspond to only 5% of the studied sources of this ecosystem, where only a few are explored and validated (Indraningrat, Smidt e Sipkema, 2016;Ye et al, 2015). with analgesic function obtained from studies in Conus magus (Verma et al, 2007).…”

Section: Alterações Genéticas Somáticas No Osteossarcomamentioning

confidence: 99%

CITOGENOTOXICIDADE E MUTAGENICIDADE DO SULFATO DE COBRE EM DIFERENTES VARIEDADES DE allium cepa LINN

Messias¹,

Brito²,

Beltrão³

et al. 2019

Conceitos Básicos Da Genética

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Anticancer agents from marine sponges

Cited by 34 publications

References 53 publications

Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones

Experimental and Theoretical Reduction Potentials of Some Biologically Active ortho-Carbonyl para-Quinones

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

CITOGENOTOXICIDADE E MUTAGENICIDADE DO SULFATO DE COBRE EM DIFERENTES VARIEDADES DE allium cepa LINN

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