Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Wang, Hailiang; Gao, Tingting; Du, Yuzhi; Yang, Hongxia; Wei, Lixin; Bi, Haibo; Ni, Wei

doi:10.1016/j.carbpol.2015.06.021

Cited by 69 publications

(41 citation statements)

References 35 publications

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“…Studies are being actively conducted to identify immunomodulators in natural products [ 48 – 51 ]. In the present study, to evaluate the effects of ZPCO on the expression of immune-related cytokines, we measured the concentrations of TNF- α , IFN- γ , IL-2, and IL-12 in the plasma rats treated with ZPCO and/or Cy ( Figure 6 ).…”

Section: Resultsmentioning

confidence: 99%

Immunostimulatory Effect of Zanthoxylum schinifolium‐Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide‐Induced Immunosuppressed Rats

Lee¹,

Park²,

Lee³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Complex oil of Zanthoxylum schinifolium and Perilla frutescens seed (ZPCO) is used as a traditional medicine due to its pharmacological activities. The aim of this study was to investigate the immunostimulatory effect of ZPCO in isolated splenocytes as well as in an immunosuppressed rat model, which was generated via oral administration of cyclophosphamide. Notably, our results showed that ZPCO exerted an immunity-enhancing effect both in vitro and in vivo. Specifically, ZPCO treatment enhanced the viability and inflammatory cytokine production of splenocytes and NK cell activity in vitro. Moreover, this product improved host defense under immunosuppressive conditions by increasing the number of immune cells and promoting the expression of cytokines involved in immune responses. Our results suggest that complex oil including Z. schinifolium should be explored as a novel immunostimulatory agent that could potentially be used for therapeutic purposes or as an ingredient in functional foods.

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Section: Resultsmentioning

confidence: 99%

Immunostimulatory Effect of Zanthoxylum schinifolium‐Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide‐Induced Immunosuppressed Rats

Lee¹,

Park²,

Lee³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Wang et al ( 2015 ) found that not only the phenolic compounds or phenolic extracts/fractions of sea buckthorn have anticancer properties: HRWP-A, a water-soluble homogenous polysaccharide with repeating units of (1 → 4)-β-D-galactopyranosyluronic residues, of which 85.2% are esterified with methyl groups, also demonstrates anticancer and immunostimulating activities in vivo . An antitumor activity assay demonstrated that HRWP-A could significantly inhibit Lewis lung carcinoma (LLC) growth in tumor-bearing mice.…”

Section: Anticancer Activity Of Sea Buckthornmentioning

confidence: 99%

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

2018

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Various parts of sea buckthorn [Elaeagnus rhamnoides (L.) A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a “golden mean” for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and animal in vivo studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.

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“…[5] Elaeagnus rhamnoides (L.) A. Nelson has been reported to have anticancer effects; the probable mechanism includes oxidation action, antiproliferation action, and antiinflammatory action. [6,7] Isorhamnetin shows a variety of pharmacological activities such as cardiovascular protection, antioxidant, anticholinesterase, and antibacterial. [8,9] Besides, its anticancer effect has been proven in esophageal cancer [10], colon cancer [11], breast cancer [12], and lung cancer [13].…”

Section: Introductionmentioning

confidence: 99%

Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways

Duan

Liang

Chai

et al. 2020

BioMed Research International

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Malignant melanoma is characterized by its bad prognosis for aggressiveness, drug resistance, and early metastasis. Isorhamnetin (3′-methoxy-3,4′,5,7-tetrahydroxyflavone; IH) is a natural flavonoid that has been investigated for its antitumor effects in breast cancer, colon cancer, and gastric cancer through inducing cell apoptosis. Given its role in tumor inhibition, no research has been conducted concerning its effect against melanoma. In the present study, we found that IH could significantly inhibit B16F10 cell proliferation and migration and induce B16F10 cell apoptosis. The examination on molecular mechanism revealed that IH could suppress the phosphorylation of Akt and the translocation of NF-κB, which are key factors in apoptosis-related pathways. We also detected that this process was related to the bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases 4 (PFKFB4) by PFKFB4 knockdown experiment. In line with in vitro study, we further provided that IH effectively inhibited tumor growth in vivo. Taken together, IH was proven to induce melanoma cell apoptosis in vitro and in vivo, which may serve as a potential agent in malignant melanoma treatment in the future.

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Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry

Cited by 69 publications

References 35 publications

Immunostimulatory Effect of Zanthoxylum schinifolium‐Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide‐Induced Immunosuppressed Rats

Immunostimulatory Effect of Zanthoxylum schinifolium‐Based Complex Oil Prepared by Supercritical Fluid Extraction in Splenocytes and Cyclophosphamide‐Induced Immunosuppressed Rats

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways

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