Anticancer Compounds from Marine Macroalgae and Their Application as Medicinal Foods

Kim, Se‐Kwon; Thomas, Noel Vinay; Li, Xifeng

doi:10.1016/b978-0-12-387669-0.00016-8

Cited by 67 publications

(36 citation statements)

References 31 publications

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“…Micro- and macro-algal extracts have become important sources of bioactive molecules with anti-cancer properties [1,2,3,4]. Their cytotoxic effect was established for various cancer cell lines, for example, human hepatocarcinoma cell line (HepG2) [5], human breast carcinoma cell line (MCF-7) [6], but also human colon carcinoma cell lines, including Caco-2 [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA

et al. 2017

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Spirulina platensis (SP) is a blue-green microalga that has recently raised attention not only as a nutritional component, but also as a source of bioactivities that have therapeutic effects and may find application in medicine, including cancer treatment. In the present study we determined the cytotoxic effect of S. platensis filtrates (SPF) on human colon cancer cell line Caco-2. Three concentrations of SPF were tested—1.25%, 2.5%, and 5% (v/v). We have found that the highest concentration of SPF exerts the strongest anti-proliferative and pro-apoptotic effect on Caco-2 cultures. The SPF negatively affected the morphology of Caco-2 causing colony shrinking and significant inhibition of metabolic and proliferative activity of cells. The wound-healing assay showed that the SPF impaired migratory capabilities of Caco-2. This observation was consistent with lowered mRNA levels for metalloproteinases. Furthermore, SPF decreased the transcript level of pro-survival genes (cyclin D1, surviving, and c-Myc) and reduced the autocrine secretion of Wnt-10b. The cytotoxic effect of SPF involved the modulation of the Bax and Bcl-2 ratio and a decrease of mitochondrial activity, and was related with increased levels of intracellular reactive oxygen species (ROS) and nitric oxide (NO). Moreover, the SPF also caused an increased number of cells in the apoptotic sub-G0 phase and up-regulated expression of mir-145, simultaneously decreasing expression of mir-17 and 146. Obtained results indicate that SPF can be considered as an agent with anti-cancer properties that may be used for colon cancer prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA

et al. 2017

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“…Macroalgae are multicellular eukaryotic algae (Faulkner, 1993). Various research studies have shown bioactive compounds derived from macroalgae with a broad range of biological activities, such as antibiotics, antioxidants, antivirals, antitumour activities (Ibtissam et al 2009), as well as cytotoxicity and induce apoptosis in cancer cells (Kim et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and antimicrobial activity of marine macro algae (Dictyotaceae and Ulvaceae) from the Persian Gulf

et al. 2015

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“…The microalgal phyla have been recognized to provide compounds with chemical and pharmacological novelty and diversity (Shimizu et al, 1996). Algae are a rich source of therapeutically active components and possess wide range of activities such as antimicrobial (Zbakh et al, 2012), antiviral (Bouhlal et al, 2011), anti-allergic (Na HJ et al, 2005, anti-coagulant (Dayong et al, 2008), anticancer (Kim et al, 2011) and antioxidant activities (Devi et al, 2011). Macroalgae has self-protecting nature against other organisms present in the environment by producing several secondary metabolites such as alkaloids, polyketides, cyclic peptides, phlobatannins, diterpenoids, sterols, quinines and lipids with many biological activities (Al-Saif et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antimicrobial activity of Ulva lactuca Linn. (Green algae) associated endophytic bacterial Strains

Habbu¹,

Warad²,

Shastri³

et al. 2016

J App Pharm Sci

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The development of resistance by pathogenic microorganisms to synthetic antibiotics encouraged researchers to find novel drugs for the treatment of infectious diseases. This opened new avenues to investigate the antimicrobial efficacy of active extracts/constituents from plant endophytes. In the present study, we have isolated endophytic bacteria (ULB-I, II and III) from green algae Ulva lactuca Linn. and the same bacteria were used for fermentation and extraction. Chloroform and ethyl acetate fractions of ULB-I, II and III were prepared and screened for in-vitro antimicrobial activities and also against Kleibesella pnumoniae infected mice in-vivo. In-vitro anti-microbial activities of ULB-I, II and III were performed against pathogenic bacteria, fungi and Mycobacterium tuberculosis H37 RV strain. From the phylogenetic analysis, the isolated endophytic organisms were identified as Bacillus subtilis JCM strain (ULB-I) and Enterobacter cloacae NBRC strain (ULB-II and III). ULB-I was found to be active against Staphylococcus aureus (1.6µg/ml) and Enterococcus feacalis (0.2µg/ml). The MIC against Staphylococcus aureus and Kleibesella pnumoniae was found to be 0.4µg/ml for ULB-II. A significant anti-fungal activity was observed against Aspergillus flavus (0.2-3.2µg/ml) and Aspergillus niger (0.2-0.4µg/ml). Further, Chloroform fraction of ULB-II and ethyl acetate fraction of ULB-III have shown significant anti-tubercular activity against the tested organism with MIC of 6.25µg/ml. This was supported by in-vivo antimicrobial activity against K. pneumoniae infection in mice and least hemolytic activity against erythrocytes was observed. HPTLC analysis of above fractions further confirmed the presence of polyvalent secondary metabolites.

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Anticancer Compounds from Marine Macroalgae and Their Application as Medicinal Foods

Cited by 67 publications

References 31 publications

The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA

The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA

Cytotoxicity and antimicrobial activity of marine macro algae (Dictyotaceae and Ulvaceae) from the Persian Gulf

In vitro and in vivo antimicrobial activity of Ulva lactuca Linn. (Green algae) associated endophytic bacterial Strains

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