Anticancer drugs based on alkenyl and boryl substituted titanocene complexes

Anticancer activity of dinuclear gallium(III) carboxylate complexes

“…Following our research on the synthesis, characterization and cytotoxic properties of metal-based anticancer drugs [47][48][49][50][51], and encouraged by the good results observed for analogous tin(IV) complexes bearing the same carboxylato ligands [48], we present the synthesis, characterization and study of the cytotoxic activity of different dimeric gallium(III) carboxylate complexes.…”

Novel gallium(III) complexes containing phthaloyl derivatives of neutral aminoacids with apoptotic activity in cancer cells

“…As many of our recent research is centred on the synthesis, characterization and cytotoxic properties of metal-based anticancer drugs [45][46][47][48][49], and in view of the lack of studies about carboxylate gallium(III) complexes in the context of medicinal chemistry [50], as well as the limited investigations concerning interactions of gallium complexes with aminoacid derivatives [51,52], here, we present the synthesis, characterization, antitumoural activity and evaluation of the mode of cell death induced by novel gallium(III) complexes containing N-phthaloyl derivatives of neutral aminoacids such as glycine and DL-alanine.…”

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

“…Thus, a subsequent study with an alkenyl monosubstituted titanocene complex (43) and its 9-BBN hydroboration product (44, Scheme 4) were synthesized and characterized. Both compounds were tested against HeLa, K562, and MBA-MB-361 cell lines [63] and showed a dose-dependent antiproliferative effect towards all cell lines and on human PBMC and stimulated PBMC (Table 4). Thus, a subsequent study with an alkenyl monosubstituted titanocene complex (43) and its 9-BBN hydroboration product (44, Scheme 4) were synthesized and characterized.…”

“…Thus, a subsequent study with an alkenyl monosubstituted titanocene complex (43) and its 9-BBN hydroboration product (44, Scheme 4) were synthesized and characterized. Both compounds were tested against HeLa, K562, and MBA-MB-361 cell lines [63] and showed a dose-dependent antiproliferative effect towards all cell lines and on human PBMC and stimulated PBMC (Table 4). The alkenyl-substituted complex 44, presented good activity against K562 (IC50 96.6 ± 3.4 µM) and moderate activity on HeLa (IC50 149.2 ± 2.9 µM) and Fem-x (IC50 133.6 ± 9.4 µM), while complex 43 presented only moderate activity on K562, HeLa ,and Fem-x (Table 4).…”