Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823

Abstract

The inhibition of GA on human gastric cancer line BGC-823 was confirmed. This effect connects with the inducing apoptosis in BGC-823 cells and the molecular mechanism might be related to the reduction of expression of apoptosis-regulated gene bcl-2, and the improvement of the expression of apoptosis-regulated gene bax. The result was also confirmed in vivo.

Prenylated caged xanthones: Chemistry and biology

“…Apoptosis is one of the main cytotoxicity mechanisms of prenylated caged xanthones studied in several cancer cells. The growth inhibition of gambogic acid on human gastric carcinoma MGC-803 , BGC-823 (Liu et al, 2005), human malignant melanoma A375 cells , KKU-100 and KKU-M156 cells (Hahnvajanawong et al, 2010) was related to the apoptosis induction of which the molecular mechanism is the regulation of gene Bcl-2, an apoptosis inhibitor and Bax, an apoptosis inducer. Gambogic acid could downregulate the expression of Bcl-2 mRNA and upregulate the expression of Bax mRNA.…”

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

“…Animal Studies HepG2 cells (5 Â 10 6 ) were implanted subcutaneously in the right flank region of BALB/cA nude mice following protocols described in the literature (30). Briefly, when tumor size increased to 100 to 200 mm 3 , the mice were randomly divided into four groups consisting of equal numbers (six) of animals.…”

Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest

“…In recent years, several studies have shown that gA can induce apoptosis and suppresses the proliferation of a variety of malignant cells, including hepatoma sMMc-7721 cells (9), gastric carcinoma Mgc-803 cells (10), Bgc-823 cells (11) and breast carcinoma McF-7 cells (12). gA mediates these responses by inhibiting tumor angiogenesis (13), acquiring chemotherapeutic resistance (14), and selectively binding tumor cells (9), among other mechanisms.…”