Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines

Sharma, Komal; Pachauri, Shakti Deep; Khandelwal, Kiran; Ahmad, Hafsa; Arya, Abhishek; Biala, P.; Agrawal, Satish; Pandey, Rishi Ranjan; Srivastava, Anjali; Srivastav, Ajeet K.; Saxena, Jitendra Kumar; Dwivedi, Anila

doi:10.1055/s-0035-1555804

Cited by 42 publications

(41 citation statements)

References 16 publications

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“…Cycle cell analysis carried out to check the synergistic effect of Noni and MTX on HeLa cell lines showed an increment in sub G0/G1 population indicating the occurrence of apoptosis which was in concurrence to decrement in the percentage of viable cells in MTT and clonogenic assays. Sharma et al (2016) reported that cell cycle distribution in MCF -7 and MDA-MB-231 cell when exposed to Noni ethyl acetate extract at IC 50 for 24, 48, and 72 h showed a noticeable increase in the G1/S phase in a time-dependent manner [20]. They have reported 81% apoptotic cells which are comparable to our results for the same time duration [22].…”

Section: Flow Cytometry To Study the Effect Of Noni On Mtx-induced Apsupporting

confidence: 88%

“…Noni has been identified for its antiproliferative potential against tumor cells. In accordance, if plant extracts and their constituents have an ability to inhibit cancer cells without disturbing normal cells, they can have an immense potential in the treatment of cancer [24,25]. The synergistic combinations of Noni with existing anticancer drugs can enhance efficacy, reduce side effects, boost immune modulation, as well as abrogate drug resistance.…”

Section: Flow Cytometry To Study the Effect Of Noni On Mtx-induced Apmentioning

confidence: 99%

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In Vitro Studies on the Synergistic Effect of Morinda Citrifolia L. (Noni) and Methotrexate on Cytotoxicity of Hela Cell Lines

Bhakti

Marar

2019

Asian J Pharm Clin Res

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Objective: Cancer remains to be one of the leading causes of death around the world. Modern targeted therapies have undeniably improved cancer patients’ survival, but search still continues for safer and more effective drugs. This work is an attempt to assess the effectiveness of cotreatment of aqueous fruit extract of Morinda citrifolia L. (Noni) on methotrexate (MTX)-induced cytotoxicity on HeLa cancer cell line. Methods: HeLa cells were treated with different concentrations of MTX and Noni alone and in combination for 24 and 48 h and studied for the cytotoxic effects by various approaches. Results: There was a dose-dependent inhibition of growth when treated with MTX in a dose range of 0.045–45.4 μg/ml and Noni for a dose range of 0.3–30 mg/ml for 48 h. The IC50 for MTX was 4.45 μg/ml (1 μM/ml), and for Noni, it was 8 mg/ml while the combination exhibited a more intensive growth inhibitory effect. Our results were confirmed with phase-contrast microscopy, whereby the number of viable cells decreased with an increase in the concentration of Noni. Cells were found to have rounded up and detached from the flask indicating apoptosis. Apoptosis in HeLa cell lines was further confirmed by DNA fragmentation and flow cytometry. Conclusion: It can be concluded that Noni may enhance MTX cytotoxicity by inducing apoptosis and cell cycle arrest. Hence, cotreatment with Noni may reduce the dosage of MTX necessary for inhibiting proliferation of malignant cells and hence decrease the toxic effects of MTX on the system.

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Section: Flow Cytometry To Study the Effect Of Noni On Mtx-induced Apsupporting

confidence: 88%

Section: Flow Cytometry To Study the Effect Of Noni On Mtx-induced Apmentioning

confidence: 99%

In Vitro Studies on the Synergistic Effect of Morinda Citrifolia L. (Noni) and Methotrexate on Cytotoxicity of Hela Cell Lines

Bhakti

Marar

2019

Asian J Pharm Clin Res

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“…M. citrifolia fresh leaf extract exhibited an in vitro inhibitory effect on the lineage cells of human epidermoid carcinoma (KB), human cervical carcinoma (HeLa), MCF‐7, human hepatocellular carcinoma (HepG2) and Vero cells and can act as a food supplement in the chemoprevention of cervical and epidermoid cancer (Thani et al , ). Its ethyl acetate fraction extract inhibited MCF‐7 and MDA‐MB‐23 cell proliferation, both of which are associated with mammary adenocarcinoma (Sharma et al , ).…”

Section: Antitumor Activitymentioning

confidence: 99%

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Torres

Magalhães

Mondêgo-Oliveira

et al. 2017

Phytotherapy Research

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Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities. While it was concluded that although M. citrifolia is widely and successfully used for the treatment or prevention of various diseases, it should be consumed carefully, and only after exhaustive studies into its chemical constituents and mechanisms of action, both in in vitro and in vivo models, as well as clinical trials. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Various reports are available for use of this plant for treatment of illness such as diabetes, blood pressure, cancers, arthritis, poor digestion etc. (Singh et al, 1984;Bruggnecate, 1992;Solomon, 1999;Whistler, 1992;Wang et al, 2002;Brown, 2012;Lee et al, 2012;Fletcher et al, 2013;Saminathan et al, 2013a;Saminathan et al, 2014b;Sharma et al, 2016). However, there is less information on the scientific validation of the Morinda fruits viz.…”

Section: Introductionmentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines

Cited by 42 publications

References 16 publications

In Vitro Studies on the Synergistic Effect of Morinda Citrifolia L. (Noni) and Methotrexate on Cytotoxicity of Hela Cell Lines

In Vitro Studies on the Synergistic Effect of Morinda Citrifolia L. (Noni) and Methotrexate on Cytotoxicity of Hela Cell Lines

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

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