Anticancer Potential and Cytotoxic Activity of NN-32, a Snake Venom Peptide, Against A549, Lung Cancer Cell Line

Kurkute, Pratibha; Jadhav, Amol; Pandit, Sangeeta V.

doi:10.1007/s10989-023-10527-0

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…NN-32 also induced anticancer activities on EAC in BALB/c mice (Das et al, 2011). A recent study showed NN-32 cytotoxixity against A549 lung cancer cell line compared to the fibroblast normal cell line (Kurkute et al, 2023). It induced apoptosis, increased ROS production and altered mitochondrial membrane potential and cell cycle arrest against A549 cells.…”

Section: Three-finger Toxin Anticancer Activitiesmentioning

confidence: 93%

Snake venom toxins: Potential anticancer therapeutics

Offor,

Piater

2023

J of Applied Toxicology

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Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment of these diseases. In this regard, Captopril used in the treatment of cardiovascular diseases was the first animal venom toxin‐based drug approved by the US Food and Drug Administration and the European Medicines Agency. Cancers cause morbidity and mortality worldwide. Due to side effects associated with the current cancer treatments including chemotherapy, radiotherapy, immunotherapy, hormonal therapy and surgery, there is a need to improve the efficacy of current treatments and/or develop novel drugs from natural sources including animal toxin‐based drugs. There is a long history of earlier and ongoing studies implicating snake venom toxins as potential anticancer therapies. Here, we review the role of crude snake venoms and toxins including phospholipase A2, L‐amino acid oxidase, C‐type lectin and disintegrin as potential anticancer agents tested in cancer cell lines and animal tumour models in comparison to normal cell lines. Some of the anti‐tumour activities of snake venom toxins include induction of cytotoxicity, apoptosis, cell cycle arrest and inhibition of metastasis, angiogenesis and tumour growth. We thus propose the advancement of multidisciplinary approaches to more pre‐clinical and clinical studies for enhanced bioavailability and targeted delivery of snake venom toxin‐based anticancer drugs.

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Section: Three-finger Toxin Anticancer Activitiesmentioning

confidence: 93%

Snake venom toxins: Potential anticancer therapeutics

Offor,

Piater

2023

J of Applied Toxicology

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A review on inflammation modulating venom proteins/peptide therapeutics and their delivery strategies: A review

Hemajha,

Singh,

Biji

et al. 2024

International Immunopharmacology

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Pharmacological activities and mechanisms of proteins and peptides derived from traditional Chinese medicine

Ni,

Zhu,

et al. 2024

Sci Tradit Chin Med

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Proteins and peptides are important active components of traditional Chinese medicine (TCM) widely found in plants, animals, and fungi. Modern research indicates that the protein constituents of TCM possess various pharmacological activities, including antitumor effect, immunomodulation, antioxidation, antihypertension, anti-inflammation, cardiovascular and nervous system protection, blood sugar regulation, and bacteriostasis effects. Despite significant progress in recent years regarding the pharmacological activities and mechanisms of TCM components, research on protein components of TCM has lagged. Many TCM protein components have yet to be effectively developed, and their pharmacological activities and mechanisms remain insufficiently elucidated. This article provides a comprehensive review of the pharmacological activities and mechanisms of TCM proteins and peptides. Additionally, the current shortcomings in research are discussed to offer some insights, aiming to promote further investigation of TCM proteins and peptides and facilitate their application in new drug development and clinical treatment.

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Anticancer Potential and Cytotoxic Activity of NN-32, a Snake Venom Peptide, Against A549, Lung Cancer Cell Line

Cited by 3 publications

References 37 publications

Snake venom toxins: Potential anticancer therapeutics

Snake venom toxins: Potential anticancer therapeutics

A review on inflammation modulating venom proteins/peptide therapeutics and their delivery strategies: A review

Pharmacological activities and mechanisms of proteins and peptides derived from traditional Chinese medicine

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