Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action

Malik, Zoya; Parveen, Rabea; Parveen, Bushra; Zahiruddin, Sultan; Khan, Mateen A.; Khan, Asifa; Massey, Sheersh; Ahmad, Sayeed; Husain, Syed Akhtar

doi:10.1016/j.jep.2021.113936

Cited by 60 publications

(41 citation statements)

References 122 publications

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“…Among all the active components in Inonotus obliquus, Inonotus obliquus polysaccharides have the broadest biological activity, such as anticancer, hypoglycemic, antiinflammatory, and anti-oxidation effects [8,22,. Through the number of Scopusindexed publication numbers (archived until 15 March 2021) for polysaccharide bioactivity, Inonotus obliquus, Inonotus obliquus polysaccharide related articles, a certain degree of upward trend can be seen (Figure 1), which means that the medicinal value and health value of Inonotus obliquus have been widely recognized and affirmed [5,6,[62][63][64], making it worthwhile to review Inonotus obliquus polysaccharides. In this review, the extraction, purification methods, and the physiochemical and structural features of Inonotus obliquus polysaccharides are summarized and discussed in detail; besides, the in vitro and in vivo evaluation and mechanisms of its bioactivities are summarized.…”

Section: Component Biological Activities Referencesmentioning

confidence: 97%

“…Glycosidic bonds are closely related to polysaccharide activity. The active polysaccharides obtained from bacteria are generally composed of glucose, and the β-(1, 3) -D glycosidic bond on the glucose backbone is necessary for their antitumor effects [ 3 , 4 , 5 ].…”

Section: Physiochemical and Structural Featuresmentioning

confidence: 99%

“…Beside reasonable prevention, it is also necessary and urgent to find suitable drugs to cure the disease. Unfortunately, existing chemical and biological drugs for cancers and diabetes have many drawbacks, such as large side effects and high prices [ 4 , 5 , 6 ]. Therefore, natural products that possess hypoglycemic, anti-oxidation, and anticancer properties is of great significance and drew the researchers’ attention [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among all the active components in Inonotus obliquus , Inonotus obliquus polysaccharides have the broadest biological activity, such as anticancer, hypoglycemic, anti-inflammatory, and anti-oxidation effects [ 8 , 22 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Through the number of Scopus-indexed publication numbers (archived until 15 March 2021) for polysaccharide bioactivity, Inonotus obliquus , Inonotus obliquus polysaccharide related articles, a certain degree of upward trend can be seen ( Figure 1 ), which means that the medicinal value and health value of Inonotus obliquus have been widely recognized and affirmed [ 5 , 6 , 62 , 63 , 64 ], making it worthwhile to review Inonotus obliquus polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

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Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Jia

Xue

et al. 2021

Polymers

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Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which possesses antitumor, antioxidant, anti-virus, hypoglycemic, and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics, and biological activities of IOPS were summarized. This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed. Furthermore, applications of IOPS were reviewed and discussed; IOPS might be a potential candidate for the treatment of cancers and type 2 diabetes. Besides, new perspectives for the future work of IOPS were also proposed.

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Section: Component Biological Activities Referencesmentioning

confidence: 97%

Section: Physiochemical and Structural Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Jia

Xue

et al. 2021

Polymers

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“…In addition, rapid biotransformation and efflux by P-gp (Pumping glycoprotein) also reduce the oral bioavailability of AND [ 8 ]. About 55% of the AND binds with human plasma proteins [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

Singh¹,

Khatri

Singh³

et al. 2021

Heliyon

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In present investigation, AND-2-HyP- β -CYD (Andrographolide-2-Hydroxypropyl- β -cyclodextrin) complex was synthesized and characterized for antiviral and pharmacokinetic profile. The linear host-guest relation suggested synthesis of a 1:1 complex of AND with 2-HyP- β -CYD by inclusion mode. The Kc, stability constant of the two phase system of AND with 2-HyP- β -CYD computed to be 38.60.x10 -3 M. 1 H NMR spectrum of AND indicated the presence of triplet at 6.63-ppm which was up-fielded in AND-2-HyP- β -CYD complex at 6.60-ppm (doublet) confirmed the insertion of AND in cavity of 2-HyP- β -CYD through lactone ring. AND-2-HyP-β-CYD complex exhibited the IC 50 of 0.1- μ g.mL -1 (E gene) and 0.29- μ g.mL -1 (N gene) against SARS-CoV-2 infected Vero6 cells. Moreover, a 1.5-fold increment in extent of absorption of AND was noticed post complexation.The bioavailability was estimated to be 15.87±3.84% and 23.84±5.46%, respectively for AND and AND-2-HyP- β -CYD complex. AND-2-HyP- β -CYD complex may be a prospective candidate for further studies to evolve as a clinically viable formulation against SARS-CoV-2.

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Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

Liu

You

et al. 2021

Medicinal Research Reviews

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Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric,

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Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action

Cited by 60 publications

References 122 publications

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

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