Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract

Hublikar, Leena V.; Ganachari, Sharanabasava V.; Patil, Veerabhadragouda B.; Nandi, Sahana; Honnad, Aishwarya

doi:10.1007/s40204-023-00219-9

Cited by 28 publications

(9 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 B). The synthesized AgONPs have shown strong anticancer activity against Hep-2 cell lines which are reliable with other studies on biogenic AgONPs that were used 30 , 65 – 67 .…”

Section: Resultssupporting

confidence: 86%

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

Ullah,

Iqbal,

Gul

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The current research aimed to study the green synthesis of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata (RC) aqueous extract as a potent reducing and stabilizing agent. The obtained RC-AgONPs were characterized using UV, FT-IR, XRD, DLS, SEM, and EDX to investigate the morphology, size, and elemental composition. The size of the RC-AgONPs was found to be ~ 21.66 nm and an almost uniform distribution was executed by XRD analysis. In vitro studies were performed to reveal biological potential. The AgONPs exhibited efficient DPPH free radical scavenging potential (71.3%), reducing power (63.8 ± 1.77%), and total antioxidant capacity (88.5 ± 4.8%) to estimate their antioxidative power. Antibacterial and antifungal potentials were evaluated using the disc diffusion method against various bacterial and fungal strains, and the zones of inhibition (ZOI) were determined. A brine shrimp cytotoxicity assay was conducted to measure the cytotoxicity potential (LC50: 2.26 μg/mL). In addition, biocompatibility tests were performed to evaluate the biocompatible nature of RC-AgONPs using red blood cells, HEK, and VERO cell lines (< 200 μg/mL). An alpha-amylase inhibition assay was carried out with 67.6% inhibition. Moreover, In vitro, anticancer activity was performed against Hep-2 liver cancer cell lines, and an LC50 value of 45.94 μg/mL was achieved. Overall, the present study has demonstrated that the utilization of R. capitata extract for the biosynthesis of AgONPs offers a cost-effective, eco-friendly, and forthright alternative to traditional approaches for silver nanoparticle synthesis. The RC-AgONPs obtained exhibited significant bioactive properties, positioning them as promising candidates for diverse applications in the spheres of medicine and beyond.

show abstract

“…9 B). The synthesized AgONPs have shown strong anticancer activity against Hep-2 cell lines which are reliable with other studies on biogenic AgONPs that were used 30 , 65 – 67 .…”

Section: Resultssupporting

confidence: 86%

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

Ullah,

Iqbal,

Gul

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Vivek et al [ 46 ] reported that AgNPs have good cytotoxic activity against MCF-7, with IC 50 values of 50 μg/ml for 24 h and IC 50 values of 30 μg/ml for 48 h treatment. Hublikar et al [ [47] , [48] , [49] ], reported that Green synthesis AgNPs from different extracts have good activity against A549 cells (IC 50 value of 85.47 μg/ml, and 49.52 g/ml) and also have good antibacterial properties towards the bacteria E. coli .…”

Section: Resultsmentioning

confidence: 99%

Apoptosis induction capability of silver nanoparticles capped with Acorus calamus L. and Dalbergia sissoo Roxb. Ex DC. against lung carcinoma cells

Thakkar,

Subramanian,

Thakkar

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…Doxorubicin an anticancer drug was used as standard, whereas the untreated cells were used as a negative control. Various concentrations (12, 25, and 55 µg/mL) of AgNPs and H. undatus peel extract were added and incubated for 48 h. After the addition of MTT, the cells were again incubated at 37ºC for 4 h. The media was then removed, 200 µL of DMSO was added to each well and the absorbance was read at 570 nm [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

A comparative study on biosynthesized silver nanoparticles from H. undatus fruit peel and their therapeutic applications

Anguraj,

Michael,

Sugumaran

et al. 2024

Discover Nano

View full text Add to dashboard Cite

The green synthesis of nanoparticles (NPs) gained significant impacts in various fields due to the use of eco-friendly approaches. In this study, silver nanoparticles (AgNPs) were synthesized from the aqueous extract of Hylocereus undatus fruit peel. The presence of AgNPs was analysed using characterization methods such as UV‒Vis, FTIR, GCMS, XRD, EDAX, and FESEM. The synthesized AgNPs showed greater antibacterial activity against Escherichia coli than against Streptococcus pneumoniae. The antifungal activity against Candida albicans was greater than that against Candida tropicalis. The IC50 value for the antibiofilm activity of the AgNPs was 2.81 µg/mL, whereas that of the H. undatus peel extract was 1.34 µg/mL. The invitro antioxidant activity of the AgNPs was evaluated using two different methods. The DPPH radical scavenging activity of the AgNPs and fruit peel extract was observed with IC50 values of 3.8 and 2.03 µg/mL respectively. On the other hand, nitric oxide radical scavenging activities were recorded and the IC50 values were calculated to be 2.8 and 2.3 µg/mL. The AgNPs demonstrated thrombolytic activity in human blood with 10, 32.36, and 56.25% lysis. The cytotoxicity of the AgNPs was minimal, with an IC50 of 0.2 µg/mL and the peel extract had the greatest cytotoxicity with an IC50 of 0.3 µg/mL. The findings of this study demonstrated that the synthesized AgNPs from H. undatus peel extract could be potential candidates for treating prostate cancer. Graphical abstract

show abstract

Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract

Cited by 28 publications

References 79 publications

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

Apoptosis induction capability of silver nanoparticles capped with Acorus calamus L. and Dalbergia sissoo Roxb. Ex DC. against lung carcinoma cells

A comparative study on biosynthesized silver nanoparticles from H. undatus fruit peel and their therapeutic applications

Contact Info

Product

Resources

About