2023
DOI: 10.1021/acs.inorgchem.3c01731
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Anticancer Potential of Diruthenium Complexes with Bridging Hydrocarbyl Ligands from Bioactive Alkynols

Giulio Bresciani,
Ján Vančo,
Tiziana Funaioli
et al.

Abstract: Diruthenacyclopentenone complexes of the general composition [Ru2Cp2(CO)2{μ–η1:η3-CHC(C(OH)(R))C(O)}] (2a–c; Cp = η5-C5H5) were synthesized in 94–96% yields from the reactions of [Ru2Cp2(CO)2{μ–η1:η3-C(Ph)C(Ph)C(O)}] (1) with 1-ethynylcyclopentanol, 17α-ethynylestradiol, and 17-ethynyltestosterone, respectively, in toluene at reflux. Protonation of 2a–c by HBF4 afforded the corresponding allenyl derivatives [Ru2Cp2(CO)3{μ–η1:η2-CHCR}]BF4 (3a–c) in 85–93% yields. All products were thoroughly characterized… Show more

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Cited by 6 publications
(17 citation statements)
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“…We provide a rare electrochemical description of diruthenium bis-cyclopentadienyl compounds. 36,37,62…”
Section: Resultsmentioning
confidence: 99%
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“…We provide a rare electrochemical description of diruthenium bis-cyclopentadienyl compounds. 36,37,62…”
Section: Resultsmentioning
confidence: 99%
“…73,74 Complex [ 2d ] + exerts a generally more potent antiproliferative effect compared to other cationic complexes based on the Ru 2 Cp 2 (CO) 3 scaffold, under analogous conditions. 36,37 We hypothesize that the higher performance of [ 2d ] + is consequent to its greater aqueous stability.…”
Section: Resultsmentioning
confidence: 99%
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