Anticandidal cytotoxicity, antitumor activities, and purified cell wall modulation by novel Schiff base ligand and its metal (II) complexes against some pathogenic yeasts

Abstract

The preparation of metal (II) complexes [CoCl(2).6H(2)O, Ni(CH(3)COO)(2).4H(2)O, Cu(CH(3)COO)(2).2H(2)O, and Zn (CH3COO)(2) .2H(2)O] with 2[N-(cinnamlidene) amino]-5-nitro phenol as a novel ligands and their biological evaluation against candida species was studied. The inhibitory effects of the tested metal complexes were tested against six pathogenic yeasts (Candida albicans, C. fructus, C. glabrata, C. oleophila, C. parapsilosis, and C. tropicalis). The effect of the most efficient metal complex (Zn(II) complex) was more pronounced at 1.25 microg/ml, while Ni(II) complex was exhibited the least suppressive effect. Co(II) and Zn(II) complexes act as potential antitumor agents, while Zn(II) complex has shown promising cytotoxic activity with slow candidal respiration rate. Addition of Zn(II) complex leading to suppression of cell wall components in all candidal cells accompanied with leaking out of amino acids. Purification of the cell wall mannoprotein of C. glabrata treated with Zn(II) complex was established, resulting one pure fissured protein peak. Cell wall protein modulation was showed by appearance of two new protein bands with molecular weights of 72 and 39 KDa in C. glabrata cells treated with Zn(II) complex compared with one pure protein band 55.6 KDa in the non treated yeast cell.

Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt

“…The results were found to be in accordance with that reported by Verma et al ( 2020 ) who stated that the compounds bearing electron-donating group such as methyl on phenyl ring exhibited better activity against fungal strains. Also, the antimicrobial activity may refer to the less bulk compound as recorded by Geweely ( 2009b ) who stated that the new complex of a tetrahedral geometry (less bulk) that enhances the rate of entrance through the candidal cell and accordingly increase its anticandidal activity and it can be used in future as novel, more active drug for designing new chemotherapeutic agents. Mohamed et al ( 2012 ) suggested that chalcone derivatives containing electron-releasing groups as OCH 3 increase the antimicrobial activity.…”

New frontiers review of some recent conservation techniques of organic and inorganic archaeological artefacts against microbial deterioration

“… SDS-PAGE of Candida glabrata cell wall protein. Marker proteins are located in Lane 1, One pure band of 55.6 KDa in C. glabrata untreated zinc protein in Lane 2 and Zinc treated C. glabrata protein showing appearance of two new protein bands with molecular weights of 72 and 39 KDa in Lane 3 ( Geweely, 2009b ). …”

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

“…Infections due to bacteria are growing more frequent over the world, and they have the potential to have a significant impact on health and become the primary cause of disease [ [1] , [2] , [3] ]. Public health is severely threatened globally by the emergence of new microbial strains that are resistant to contemporary antibiotics [ 4 , 5 ].…”