Anticarcinogenic and antimicrobial activity effects of the ellagic acid extract

Abstract

Recently, plant-derived compounds have been attracted increasable attention as alternative cancer remedies to enhance cancer prevention and healing, and as efficient antimicrobials, because of their low toxicity, low cost and fewer side effects. Ellagic acid (EA) is a natural phenolic constituent; previous studies have reported its antitumor properties when used in in vitro models. In this study, we have investigated the activity of a low concentration of EA against four different human cancer cell lines (SK-N-SH, Caov-3, SW-1088 and BxPC-3) which are very hard in the treatment and there is no available data about EA influence on them. Additionally, the effect of EA has assessed against (H. Pylori (Helicobacter pylori), P.aeruginosa (Pseudomonas aeruginosa), A. tumefaciens: Agrobacterium tumefaciens (Rhizobium radiobacter) and E. herbicola: Enterobacter agglomerans (Erwiniaherbicola) and two are Gram-positive bacterium S. aureus (Staphylococcus aureus) and C. acnes (Cutibacterium acnes)) strains which are resistant to the antibiotics. The results suggest that EA may have a potential role as an adjunct therapy for neuroblastoma, ovarian, pancreatic and astrocytoma cancers, in addition to its activity as an antimicrobial agent as it has been proved in this study against H. pylori, P.aeruginosa, A. tumefaciens, E. herbicola, S. aureus and C. acnes strains.

Investigating the anti-growth, anti-resistance, and anti-virulence activities of Schoepfia schreberi J.F.Gmel. against the superbug Acinetobacter baumannii

“…EA and pteleoelagic acid isolated from Pteleopsis hylodendron exhibited potent activity against P. aeruginosa , K. pneumoniae , Streptococcus pyogenes , Bacillus cereus , S. aureus , Salmonella typhi, and E scherichia coli [ 49 ]. Other studies have reported the anti-bacterial activity of EA against S. aureus , P. aeruginosa , Helicobacter pylori , S. epidermidis , and K. pneumoniae [ 50 , 51 ]. The biological activity of EA may be associated with its action on the bacterial cell membranes.…”

Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

“…The fact that MRSA is a common hospital pathogen responsible for the infection and still has significant mortality makes all of these findings vitally crucial [240]. The antibacterial activity of EA against numerous Gram-negative and Gram-positive pathogens, including P. aeruginosa (the MIC value = 500 µg•mL −1 ), Enterobacter agglomerans, Cutibacterium acnes, and S. aureus (the MIC value = 15.6 µg•mL −1 ), along with MDR strains, was confirmed [241]. Fontaine et al (2017) examined the effect of xyloside and rhamnoside of EA on the ability of MSSA S. aureus (isolated from bone and bone marrow infection and mutant in terms of the sarA gene-impaired biofilm formation ability) to form biofilm.…”

“…In the study by Al-Mugdadi et al (2019), ellagic acid showed antibacterial activity against P. aeruginosa (the MIC value = 500 µg•mL −1 ) [241]. Another study identified the effects of EA, epigallocatechin, and tannic acid on P. aeruginosa (PAO1) in the inhibition of biofilm formation and the reduction of bacterial adhesive capacity.…”

Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity

“…Structurally, EA is considered a dimeric gallic acid derivative because it constitutes a dilactone of hexahydroxy-diphenic acid (HHDP) (Figure 1) [9]. In recent decades, EA has attracted increasing attention due to its pronounced antioxidant [10,11], anticancer [12][13][14], anti-inflammatory [15,16], and antimutagenic properties [17,18]. Many studies have shown that EA can regulate a range of cell signaling 2 of 18 pathways to prevent, mitigate or slow the progression of chronic diseases such as cardiovascular disease [19] and neurodegenerative diseases [20], diabetes [21], and cancer [13,14,22].…”

“…pronounced antioxidant [10,11], anticancer [12][13][14], anti-inflammatory [15,16], and antimutagenic properties [17,18]. Many studies have shown that EA can regulate a range of cell signaling pathways to prevent, mitigate or slow the progression of chronic diseases such as cardiovascular disease [19] and neurodegenerative diseases [20], diabetes [21], and cancer [13,14,22].…”