Anticoagulant effect and plasma kinetics of fluorophenindione after a single dose in man

Abstract

After administration of a single loading dose (80 mg p.o.) of fluorophenindione, the prothrombin level decreased to 37% in 24 h, and the effect lasted for 48 h. Accordingly, fluorophenindione can be classified as an anticoagulant with an ""intermediate'' effect. Its elimination half-life was 31 h, which is longer than that of phenindione, because of the greater stability of the fluorinated derivate.

Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants

“…An intermediate half-life has been described for fluindione, similar to the half-life of the more potent enantiomer of warfarin [ 18 ]. One study described a fluindione half-life of 31h [ 71 ], while another found a median half-life of 69h [ 70 ]. Fluindione is less often displaced by other drugs in their receptors and it has higher affinity to albumin than warfarin [ 70 ].…”

Pharmacokinetics of 2-phenyl-1,3-indandione in the rat after i.v. and oral administration

“…Most 2-aryl-l,3-indandiones have been found to be rapidly and almost completely absorbed from the gastrointestinal tract (5,15,16).…”

“…According to this model the following equations apply:after i.v. The data on the absorption and elimination, cited in the Introduction, were determined at about 280 (IS) or 338(5,16) nm. It hasrecently been demonstrated that the oxidation products of PID absorb at the same wavelengths(18).…”