Anticodeine aptamer immobilized on a Whatman cellulose paper for thin-film microextraction of codeine from urine followed by electrospray ionization ion mobility spectrometry

Hashemian, Zahra; Khayamian, Taghi; Saraji, Mohammad

doi:10.1007/s00216-014-8392-5

Cited by 48 publications

(19 citation statements)

References 29 publications

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“…This modification can be done by the covalent bonding [110] or by the deposition of a thin layer of sorptive phase [111]. The coating of paper with polymers of both synthetic [112] and natural origins [113] appears as an interesting way to synthesize versatile sorptive phases. Conventional coatings in microextraction, such as PDMS [114], have been recently complemented by other approaches.…”

Section: Trends Natural Products For Simplifying the Analytical Workmentioning

confidence: 99%

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

et al. 2019

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Green analytical chemistry principles aim to minimize the negative impact of analytical procedures in the environment, which can be considered both at close (to ensure the safety of the analysts) and global (to conserve our natural resources) levels. These principles suggest, among other guidelines, the reduction/minimization of the sample treatment and the use of renewable sources when possible. The first aspect is largely fulfilled by microextraction, which is considered to be among the greenest sample treatment techniques. The second consideration is attainable if natural products are used as raw materials for the preparation of new extraction phases. This strategy is in line with the change in our production system, which is being gradually moved from a linear model (take-make-dispose) to a circular one (including reusing and recycling as key terms). This article reviews the potential of natural products as sorbents in extraction and microextraction techniques from the synergic perspectives of two research groups working on the topic. The article covers the use of unmodified natural materials and the modified ones (although the latter has a less green character) to draw a general picture of the usefulness of the materials.Separations 2020, 7, 2 2 of 22 principle identifies one of the trends of current research in analytical sciences, it is difficult to be applied when complex samples containing the analytes at very low concentrations are processed. In such scenarios, the simplification of the sample treatment and the reduction of the sources applied (reagents, energy) can be a more practical objective, at least currently. Microextraction techniques fulfill the latter criteria [8], and they are considered among the greenest sample treatment techniques [9].Microextraction techniques have evolved in the last decade following some key trends. Among them, the development of new extraction phases can be highlighted, considering the context of this review article. In this evolution, the tenth (use of renewable resources) and eleventh (replace or remove toxic reagents) principles of GAC are especially relevant [7]. In the liquid microextraction context, environmentally friendly solvents [10,11] such as CyreneTM [12] and deep eutectic solvents [13] are clear examples of this progress.The paradigm of our production system, which up to now has been based on a linear "take-make-dispose" model, is progressively changed to a circular model [14] where reusing, repairing, refurbishing, and recycling appear as key terms. The use of surpluses of natural products as raw materials for the preparation of new sorbents is an interesting contribution of analytical chemistry for changing the production model. This review article, which combines the vision of two research groups working in the topic, tries to draw the general picture of the potential of natural products for the synthesis of new sorptive phases in solid phase extraction and solid phase microextraction. The article will cover strategies with different green characterist...

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Section: Trends Natural Products For Simplifying the Analytical Workmentioning

confidence: 99%

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

et al. 2019

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“…Even though codeine is far less widely used as an illicit drug, aptamer-based sensors have been published, but their effectiveness in biological samples (e.g., urine or blood) has not been shown (Saberian et al, 2011 ; Huang et al, 2013 ). A method to extract codeine from urine based on an aptamer has been developed, but it relies on electrospray ionization ion mobility spectrometry for quantification of the extracted codeine (Hashemian et al, 2015 ).…”

Section: Small Molecule Aptasensorsmentioning

confidence: 99%

Selection and Biosensor Application of Aptamers for Small Molecules

2016

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Small molecules play a major role in the human body and as drugs, toxins, and chemicals. Tools to detect and quantify them are therefore in high demand. This review will give an overview about aptamers interacting with small molecules and their selection. We discuss the current state of the field, including advantages as well as problems associated with their use and possible solutions to tackle these. We then discuss different kinds of small molecule aptamer-based sensors described in literature and their applications, ranging from detecting drinking water contaminations to RNA imaging.

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“…The extraction procedure has been described in reference [18]. In summary, at first anticodeine or antiacetamiprid immobilized aptamer cellulose paper was attached to a stainless steel cutter and together were named "sampler".…”

Section: Tfme Proceduresmentioning

confidence: 99%

“…In 2013, Saraji et al developed surface modification of cellulose paper with different chemical reagents [17]. Aptamer-based TFME method as a sorbent for the extraction of codeine has been reported in our group [18]. In that work, the amino-modified aptamer was immobilized on the oxidized cellulose surface through a covalent bond.…”

Section: Introductionmentioning

confidence: 99%

Immobilized aptamer paper spray ionization source for ion mobility spectrometry

Zargar

Khayamian

Jafari

2017

Journal of Pharmaceutical and Biomedical Analysis

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A selective thin-film microextraction based on aptamer immobilized on cellulose paper was used as a paper spray ionization source for ion mobility spectrometry (PSI-IMS), for the first time. In this method, the paper is not only used as an ionization source but also it is utilized for the selective extraction of analyte, based on immobilized aptamer. This combination integrates both sample preparation and analyte ionization in a Whatman paper. To that end, an appropriate sample introduction system with a novel design was constructed for the paper spray ionization source. Using this system, a continuous solvent flow works as an elution and spray solvent simultaneously. In this method, analyte is adsorbed on a triangular paper with immobilized aptamer and then it is desorbed and ionized by elution solvent and applied high voltage on paper, respectively. The effects of different experimental parameters such as applied voltage, angle of paper tip, distance between paper tip and counter electrode, elution solvent type, and solvent flow rate were optimized. The proposed method was exhaustively validated in terms of sensitivity and reproducibility by analyzing the standard solutions of codeine and acetamiprid. The analytical results obtained are promising enough to ensure the use of immobilized aptamer paper-spray as both the extraction and ionization techniques in IMS for direct analysis of biomedicine.

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Anticodeine aptamer immobilized on a Whatman cellulose paper for thin-film microextraction of codeine from urine followed by electrospray ionization ion mobility spectrometry

Cited by 48 publications

References 29 publications

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

Selection and Biosensor Application of Aptamers for Small Molecules

Immobilized aptamer paper spray ionization source for ion mobility spectrometry

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