Anticyanobacterial phenolic constituents from the aerial parts of Eupatorium fortunei Turcz

Abstract

Four thymol derivatives and two phenolic compounds were isolated from the aerial parts of Eupatorium fortunei. The new structures were elucidated to be 7,8,9-trihydroxythymol (1), and 8,10-didehydro-7,9-dihydroxythymol (2) by means of MS and NMR analysis. The known compounds were identified as 8,9,10-trihydroxythymol (3), 10-acetoxy-8,9-dihydroxythymol (4), o-coumaric acid (5) and 4-(2-hydroxyethyl)benzaldehyde (6). Compound 3 showed strongest inhibitory effect on the growth of Microcystis aeruginosa in comparison with CuSO.

Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortunei

“…Separation of the EtOAc-soluble fraction of a MeOH extract of the aerial part of E. fortunei by silica gel chromatography and preparative thin-layer chromatography (TLC) afforded five new (1)(2)(3)(4)(5) and eleven known compounds (6-16) (Figure 1).…”

“…In our study on the cytotoxic constituents of Chinese herbal medicines, many species have been screened for cytotoxic effect, and E. fortunei has been found to be an active species. Two new dibenzo [b,d]furan derivatives, eupatodibenzofuran A (1) and eupatodibenzofuran B (2), a new 4-chromanone, 6-acetyl-8-methoxy-2,2-dimethylchroman-4-one (3), a new acetophenone derivative, eupatofortunone (4), a new dithiecine derivative, eupatodithiecine (5), and eleven known compounds (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) have been isolated and confirmed from the aerial part of E. fortunei. This report describes the structural elucidation of five new compounds 1-5 and the inhibitory activities of 1 against non-small-cell lung cancer and breast cancer cells.…”

“…The aerial part of E. fortunei (Chinese name: Pei-Lan) has been used as a traditional medicine for the treatment of various diseases such as flu, poor appetite, constipation, nausea, and siriasis [ 1 ]. Diverse monoterpenoids [ 2 , 3 , 4 , 5 , 6 ], triterpenoids [ 2 , 7 ], sesquiterpenoids, stereoisomer, coumarins [ 7 ], pyrrolizidine alkaloids [ 7 , 8 ], benzofuran [ 4 , 9 ], and their derivatives were isolated from this species in the past studies. Many of these isolated compounds showed anti-inflammatory [ 5 ], anti-bacterial [ 3 , 4 ], anti-cancer [ 6 ], and anti-diabetic [ 7 ] activities.…”

“…Diverse monoterpenoids [ 2 , 3 , 4 , 5 , 6 ], triterpenoids [ 2 , 7 ], sesquiterpenoids, stereoisomer, coumarins [ 7 ], pyrrolizidine alkaloids [ 7 , 8 ], benzofuran [ 4 , 9 ], and their derivatives were isolated from this species in the past studies. Many of these isolated compounds showed anti-inflammatory [ 5 ], anti-bacterial [ 3 , 4 ], anti-cancer [ 6 ], and anti-diabetic [ 7 ] activities. In our study on the cytotoxic constituents of Chinese herbal medicines, many species have been screened for cytotoxic effect, and E. fortunei has been found to be an active species.…”

Quantitative Determination of p-Cymene, Thymol, Neryl Acetate, and β-Caryophyllene in Different Growth Periods and Parts of Eupatorium fortunei Turcz. by GC-MS/MS

“…It has been applied for relieving nausea, vomiting, and poor appetite due to dampness obstruction since thousands of years ago [ 1 ]. Previous studies showed that the plant contains a number of bioactive natural products [ 2 , 3 ]. The content determination of total volatile oil in Eupatorium fortunei Turcz.…”