Antidepressant and anti-amnesic effects of the aqueous lyophilisate of the leaves of Leptadenia arborea on an animal model of cognitive deficit associated depression

Ngoupaye, Gwladys Temkou; Yassi, Francis Bray; Bahane, Doriane Amanda Nguepi; Pahaye, David Bougolla; Bum, Elisabeth Ngo

doi:10.1016/j.biopha.2020.110603

Cited by 13 publications

(8 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the administration of PCPA significantly depleted serum 5-HT levels in mice. Consequently, the PCPA group exhibited a decreased considerably travel time in the new arm of Y-maze and a reduced recognition index in the NORT, indicating the occurrence of NCDs, consistent with the results of studies of PCPA-induced NCDs among mice ( Ngoupaye et al, 2020 ; Li et al, 2022a ). Interestingly, a decrease in time spent in the central area in OFT demonstrated depression-like behaviors in PCPA-treated mice.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Liu

Sun

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Neurocognitive disorders (NCDs) include complex and multifactorial diseases that affect many patients. The 5-hydroxytryptamine (5-HT) neuron system plays an important role in NCDs. Existing studies have reported that para-chlorophenylalanine (PCPA), a 5-HT scavenger, has a negative effect on cognitive function. However, we believe that PCPA may result in NCDs through other pathways. To explore this possibility, behavioral tests were performed to evaluate the cognitive function of PCPA-treated mice, suggesting the appearance of cognitive dysfunction and depression-like behavior. Furthermore, 16S rRNA and metabolomic analyses revealed that dysbiosis and acetate alternation could be related to PCPA-induced NCDs. Our results suggest that not only 5-HT depletion but also dysbiosis and acetate alternation contributed to PCPA-related NCDs. Specifically, the latter promotes NCDs by reducing short-chain fatty acid levels. Together, these findings provide an alternative perspective on PCPA-induced NCDs.

show abstract

Section: Discussionsupporting

confidence: 88%

“…These findings are supported by the reports from Ngoupaye et al (2020) and Riga et al (2020) that PCPA-treated mice revealed depression-like behavior. In the above studies, the authors reported that antidepressants could decrease the impact of PCPA on NCDs.…”

Section: Discussionsupporting

confidence: 87%

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Liu

Sun

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…An increase in immobility time is usually referred to as behavioral despair in animals and is claimed to represent human depression [36][37][38], suggesting that the KG-treated rats were prevented from depressive-like behaviors. Previous studies by Gardier and colleague [39] showed that a decrease in immobility was linked to antidepressant activity [40][41][42]. Taken together, these results indicate that the KG-HE extract possesses nootropic potential.…”

Section: Discussionsupporting

confidence: 58%

<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

Ella¹,

Fewou²,

Koloko³

et al. 2022

AJBLS

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a multifactorial, progressive neurodegenerative disorder with dementia and persistent impairment of cognitive functions as the main clinical characteristics. Although signs of progress are being made in developing AD therapy, there is no effective drug capable of stopping and/or slowing down the progression of the disease. We have previously indicated in an in vitro setting of AD that Khaya grandifololia (KG) crude extract possesses antioxidant, antiinflammatory, and neuroprotective activities. In the current work, we have evaluated the activity of KG hydroethanolic (KG-HE) extract in preventing cognitive impairment and promoting memory improvement in vivo. Results from behavioral tests indicated a significant improvement in memory performance and a delay in depression-like behavior upon treatment of rats with KG-HE extract (5, 25, and 50 mg/kg) or donepezil (1 mg/kg) as standard. Because scopolamine (1 mg/kg) impaired cognitive performance in the tail suspension test, Morris Water Maze test, and Novelty Suppressed Feeding Test, KG-HE extract (5, 25, and 50 mg/kg) or donepezil (1 mg/kg) treatment prevented scopolamine-induced performance impairment. Moreover, both KG-HE extract (5, 25, and 50 mg/kg) and donepezil (1 mg/kg) prevented the scopolamine-induced cognitive impairment by inhibiting the acetylcholinesterase activity. In addition, the brain parameters of stress oxidation (SOD, CAT, and GSH) reduced by scopolamine treatment were regulated by the administration of KG-HE extract or the standard drug donepezil. An increase in the MDA level and the phosphatase activity both in the serum and brain due to scopolamine treatment was restored by the administration of KG-HE extract or donepezil. Taken together, these results suggest that KG-HE extract improves cognition and relieves the scopolamine-induced cognitive impairment via activation of the cholinergic and anti-oxidation systems in rats.

show abstract

“…A total of 56 young adult Swiss mice; males (42) and females (14) aged two months and weighing between 20 and 24 g were used. ese animals were raised in the Animal House of the Faculty of Science of the University of Buea (Cameroon) where they were kept in standard cages at room temperature.…”

Section: Animals and Ethical Considerationmentioning

confidence: 99%

“…e time taken by the animal to explore object A or object B was recorded as TA and TB, respectively. A discrimination index (DI) was calculated for each animal using the formula (DI � (TB − TA)/(TB + TA) [40][41][42].…”

Section: Novel Object Recognition Testmentioning

confidence: 99%

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

Wanyu

Kouemou

Taïwe

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Ethanol consumption is widely accepted despite its addictive properties and its mind-altering effects. This study aimed to assess the effects of Dichrocephala integrifolia against, memory impairment, on a mouse model of chronic and binges ethanol feeding. Mice were divided, into groups of 8 animals each, and received distilled water, Dichrocephala integrifolia aqueous extract (25; 50; 100; or 200 mg/kg) or memantine (200 mg/kg) once a day, while fe, with Lieber-DeCarli control (sham group only) or Lieber-DeCarli ethanol diet ad libitum for 28 days. The Y maze and the novel object recognition (NOR) tests were used to evaluate spatial short-term and recognition memory, respectively. Malondialdehyde, nitric oxide, glutathione levels, and proinflammatory cytokines (Il-1β, TNF-α, and Il-6) were evaluated in brain homogenates following behavioral assessments. The results showed that chronic ethanol administration in mice was associated with a significant ( p < 0.001 ) reduction in the spontaneous alternation percentage and the discrimination index, in the Y maze and the NOR tests, respectively. It significantly ( p < 0.01 ) increased oxidative stress and inflammation markers levels in the brain. Dichrocephala integrifolia (100 and 200 mg/kg) as well as memantine (200 mg/kg) significantly ( p < 0.001 ) increased the percentage of spontaneous alternation and the discrimination index, in the Y maze and NOR tests, respectively. Dichrocephala integrifolia (100 and 200 mg/kg) likewise memantine (200 mg/kg) significantly ( p < 0.01 ) alleviated ethanol-induced increase, in the brain malondialdehyde level, nitric oxide, Il-1β, TNF-α, and Il-6. From these findings, it can be concluded that Dichrocephala integrifolia counteracted memory impairment, oxidative stress, and neuroinflammation induced by chronic ethanol consumption in mice.

show abstract

Antidepressant and anti-amnesic effects of the aqueous lyophilisate of the leaves of Leptadenia arborea on an animal model of cognitive deficit associated depression

Cited by 13 publications

References 76 publications

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

Contact Info

Product

Resources

About

Antidepressant and anti-amnesic effects of the aqueous lyophilisate of the leaves of Leptadenia arborea on an animal model of cognitive deficit associated depression

Cited by 13 publications

References 76 publications

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders

&lt;i&gt;Khaya grandifololia&lt;/i&gt; Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

Contact Info

Product

Resources

About

<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats