Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

Manev, Hari; Uz, Tolga; Smalheiser, Neil R.; Manev, Radmila

doi:10.1016/s0014-2999(00)00904-3

Cited by 199 publications

(114 citation statements)

References 9 publications

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“…Based on these findings, studies were initiated to determine if antidepressants influence neuronal remodeling, particularly neurogenesis. The results of this work reveal the exciting discovery that antidepressant treatment increases adult neurogenesis in hippocampus (Figure 3) (Malberg et al 2000b;Madsen et al 2000;Manev et al 2000;see Duman et al 2000;Jacobs et al 2000). Up-regulation of neurogenesis is observed with different classes of antidepressants, including 5-HT and NE selective reuptake inhibitors, monoamine oxidase inhibitors, and electroconvulsive seizure.…”

Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 70%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

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Demonstration of neurogenesis in adult brainOur understanding of how the brain functions and undergoes adaptation and plasticity has changed dramatically over the past several years. A great deal of work has demonstrated that altered levels of neurotransmitters, second messenger pathways, and gene expression profiles underlie cellular and behavioral plasticity. This includes models of learning and memory as well as models of depression, anxiety, and psychosis, and the long-term actions of psychotropic drugs. However, it is now becoming increasing evident that changes in cellular morphology and even more pronounced alterations in brain structure also contribute to neural plasticity or remodeling. At the cellular level these changes can occur in the form of up or down-regulation of synapse formation and spine density or extension and retraction of dendrites. Another very dramatic example is up or down-regulation of neurogenesis in adult brain. Studies in recent years demonstrate that new cell birth occurs in adult brain and that the rate of neurogenesis and the survival of new neurons is regulated by a number of environmental, endocrine, and pharmacological treatments.In this paper we discuss the evidence that structural remodeling may be involved in the pathophysiology and treatment of mood disorders. The potential role of neurogenesis is also discussed as well as the molecular mechanisms which underlie antidepressant regulation of new cell birth and survival. The studies to date suggest an exciting possibility for the role of neurogenesis

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Section: Antidepressant Treatment Increases Adult Neurogenesismentioning

confidence: 70%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

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“…Recent studies have shown that chronic, but not acute, antidepressant treatment also increases the neurogenesis of dentate gyrus granule cells (D'Sa and Duman 2002;Jacobs et al 2000;Manev et al 2001). These studies demonstrate that chronic administration of different classes of antidepressant treatment, including norepinephrine, SSRIs, and electroconvulsive seizures, increases the proliferation and survival of new neurons.…”

Section: Antidepressants Also Regulate Hippocampal Neurogenesis: Is Tmentioning

confidence: 78%

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

Manji

Quiróz

Sporn

et al. 2003

Biological Psychiatry

445

259

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“…They bind to specific receptors in this region and thus cause a drop in both BDNF mRNA and protein in neurons. In view of the opposite effects of stress and antidepressants on hippocampal neurogenesis, it is quite plausible that alterations in hippocampal neurogenesis are fundamental to the clinical syndrome of depression (Jacobs et al 2000;Manev et al 2001;D'Sa and Duman 2002;Kempermann 2002).…”

Section: Neurotrophic Factorsmentioning

confidence: 99%

“…It was observed that CREB overexpression in the dentate gyrus or BDNF injection results in an antidepressant-like effect in behavioural models of depression and antidepressant efficacy in rats (Siuciak et al 1997;Chen et al 2001a;Shirayama et al 2002). Chronic, but not acute, antidepressant treatment also increases the neurogenesis of dentate gyrus granule cells (Jacobs et al 2000;Manev et al 2001;D'Sa and Duman 2002). Lithium, one of the most effective antidepressant potentiating agents, also increases neurogenesis in the dentate gyrus (Chen et al 2000).…”

Section: Neurotrophic Factorsmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

227

126

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro

Cited by 199 publications

References 9 publications

Regulation of Adult Neurogenesis by Antidepressant Treatment

Regulation of Adult Neurogenesis by Antidepressant Treatment

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

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