Antidiabetic profiling, cytotoxicity and acute toxicity evaluation of aerial parts of Phragmites karka (Retz.)

Mazumder, Kishor; Sumi, Tahamina Sultana; Golder, Mimi; Biswas, Biswajit; Maknoon,; Kerr, Philip G.

doi:10.1016/j.jep.2021.113781

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…All these etiological relationships direct to a theory benefit of antioxidants in the treatment or management of diabetic patients. 17 Keeping this factor in the account along with the folkloric use of this plant, we have explored the antidiabetic potential of the sample which includes a preliminary antihyperglycemic screening through OGTT followed by the STZ-induced antidiabetic activity test.…”

Section: Resultsmentioning

confidence: 99%

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Antioxidative and Antidiabetic Potentials of the Pneumatophores of Heritiera fomes Buch. Ham.

Sultana

Golder

Biswas³

et al. 2022

Dhaka Univ. J. Pharm. Sci

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This research work focuses on determining the antidiabetic and antioxidative properties of ethanolic extract of Heriteira fomes pneumatophores. The in vitro antioxidative activity was tested through several qualitative and quantitative assays which revealed the radical scavenging activity of this plant. The in vivo antihyperglycemic activity of plant extract was confirmed by the oral glucose tolerance test in the mice model. The antidiabetic potential was tested on streptozotocin-induced diabetic rats followed by measuring several hematological parameters and lipid profiles where the extract significantly affected those parameters. The results suggest that H. fomes pneumatophores might be a potential source of antioxidative and antidiabetic bioactive compounds. Dhaka Univ. J. Pharm. Sci. 20(3): 283-291, 2022 (June) Centennial Special Issue

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Section: Resultsmentioning

confidence: 99%

“…Blood glucose level was measured using the glucometer and compatible blood glucose strips at 0, 60 and 120 minutes after glucose administration. 17 Evaluation of antidiabetic activity on STZinduced diabetic rats. STZ (60 mg/kg b.w.)…”

Section: Superoxide Radical Scavenging Activity Testmentioning

confidence: 99%

Antioxidative and Antidiabetic Potentials of the Pneumatophores of Heritiera fomes Buch. Ham.

Sultana

Golder

Biswas³

et al. 2022

Dhaka Univ. J. Pharm. Sci

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“…Alpha-glucosidase and alpha-amylase are the mediatory enzymes responsible for absorption of glucose from food sources. Medicinal plants rich in phenolic, flavonoid and tannin contents show inhibitory effect on alpha-amylase and alpha-glucosidase [26] . These enzyme inhibitors act by directly blocking the active centers of the enzyme at several sites [27] In our experiment, although voglibose showed inhibition of alpha-glucosidase enzyme (IC 50 = 0.3 mg/ml) as shown in figure 4, but no inhibitory effect of D. grandiflora extract was observed.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical investigation and assessment of pharmacological properties of leaves of Duabanga grandiflora

Jahan¹,

Kundu²,

Sultana³

et al. 2021

J. Med. Plants Stud.

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Duabanga grandiflora-a medicinal plant from Lythraceae family, is native to some countries of South Asian region. This plant has many uses in folk medicine. But there are lack of scientific reports comparing to its therapeutic importance. Our study was designed to assess phytochemical and biological effects of D. grandiflora leaves. From the phytochemical investigation we came to know that this extract possesses many important phytochemical groups as secondary metabolites. This extract showed the presence of many antioxidant compounds in both qualitative and quantitative antioxidant assays. In DPPH radical and hydrogen peroxide scavenging assay, the SC50 were 58 and 50 μg/ml, respectively. In FeCl3 reducing power assay, the RC50 was found to be 57 μg/ml. Total content of phenolic, flavonoid and tannin were measured as 127 mg GAE/g, 285 mg QE/g and 132 mg GAE/g, respectively. This plant showed significant blood glucose level reduction over the short period of time in oral glucose tolerance test and for long term in alloxan-induced diabetic tests, although it did not express any significant response to α-glucosidase enzyme inhibition. In acetic acid-induced writhing test, this plant showed significant pain inhibition which was followed by significant reduction in paw edema induced by formalin. D. grandiflora increased the latency of defecation and decreased the stool count in castor oilinduced diarrheal test. Lastly, we also observed prominent CNS depression activity of this extract in open field model in mice. All of these results were compared with standard drugs and the responses were found in dose-dependent manner. These observations signify the utilization of this plant in folk medicinal system and we hope that these initial results will be beneficial to conduct higher research on this plant to isolate newer bioactive molecules.

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“…Biochemical parameters also revealed that AE-AI treatment reduced the levels of ALT, AST, and ALP, which are the indicators of hepatic damage. The improvement in the hepatic enzyme levels can be attributed to the decrease in free fatty acid and peroxides in the serum and reduced oxidation. , TII DM is linked with diabetic nephropathy, which normally leads to renal morbidity and mortality. In this ailment, glomerular sclerosis and fibrosis occur, which results in proteinuria.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Ethanolic Extract of Adiantum incisum Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress

et al. 2022

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This study was designed to investigate the antidiabetic effects of the aqueous ethanolic extract of Adiantum incisum Forssk. whole plant (AE-AI) in order to validate the folkloric claim. Methods: Streptozotocin (STZ) was used to induce type 2 diabetes mellitus (TII DM) in male Sprague−Dawley rats. STZ-induced diabetic rats were later treated orally with either AE-AI (125, 250, and 500 mg/kg) or glibenclamide for 35 days. Blood glucose levels were measured weekly and on day 35, animals were sacrificed, and blood samples and tissues were harvested for subsequent antioxidant and histopathological analyses. AE-AI was also analyzed in vitro for phytochemical, antioxidant, and α-amylase inhibitory assays. Results: The phytochemical screening of AE-AI confirmed the presence of essential bioactive compounds like cardiac glycosides, flavonoids, phenolic compounds, saponins, and fixed oils. AE-AI demonstrated abundant amounts of total phenolic and flavonoid contents and displayed prominent antioxidant activity as assessed via DPPH, phosphomolybdate, and nitric oxide scavenging assays. AE-AI treatment also showed α-amylase inhibitory activity comparable to acarbose. In addition, AE-AI treatment exhibited a wide margin of safety in rats and dosedependently reduced STZ-induced blood glucose levels. Moreover, AE-AI increased the levels of GSH, SOD, catalase, and reduced MDA, and therefore prevented pathological effects of STZ on the kidney, liver, and pancreas. The blood glucose regulatory effect and antioxidant activity of AE-AI also aided in normalizing TII DM-mediated dyslipidemias. GC-MS analysis also demonstrated several potential antidiabetic phytoconstituents in AE-AI. Conclusion: These findings reveal that AE-AI possesses certain pharmacologically active compounds that can effectively treat STZ-induced TII DM owing to its antioxidant and α-amylase inhibitory potentials.

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Antidiabetic profiling, cytotoxicity and acute toxicity evaluation of aerial parts of Phragmites karka (Retz.)

Cited by 17 publications

References 41 publications

Antioxidative and Antidiabetic Potentials of the Pneumatophores of Heritiera fomes Buch. Ham.

Antioxidative and Antidiabetic Potentials of the Pneumatophores of Heritiera fomes Buch. Ham.

Phytochemical investigation and assessment of pharmacological properties of leaves of Duabanga grandiflora

Aqueous Ethanolic Extract of Adiantum incisum Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress

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