Antiepileptic activity and subtype-selective action of flupirtine at GABAAreceptors

Effect of flupirtine on seizure activity and its interactions with antiepileptic drugs in rats.

“…This is a possible explanation for potentiation of anticonvulsant action of benzodiazepines by flupirtine. [14] Naveen Kumar M, et al (2011) also shows similar results. He studied the anticonvulsant action of flupirtine, in comparison with phenytoin and DMSO as a control in albino mice by using MES method.…”

“…Results of present study are in accordance with previous studies that demonstrate anticonvulsants activity of flupirtine. [11][12][13][14][15] Anticonvulsant effect of flupirtine alone and in combination with other established anticonvulsant drugs in subtherapeutic doses was investigated here. Objectives of using combination of flupirtine with other anticonvulsants are to achieve synergism, to reduce the duration and severity of suffering of patients from seizure, to broaden the spectrum of anticonvulsant activity and to reduce the incidence of adverse effects by using low doses of drugs.…”