Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer

Alawi, Reem Al; Alhamdani, Mohamed Saiel Saeed; Hoheisel, Jörg D.

doi:10.1016/j.biopha.2019.109522

Cited by 34 publications

(25 citation statements)

References 49 publications

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“…Date palm fruit ( Phoenix dactylifera L.) is an endemic functional food, with great nutritional and economic importance due to its phytochemical compositions (Al Alawi, Alhamdani, Hoheisel, & Baqi, ). Dates are considered as the main crop produced in Algeria; with 1,058,559 tons harvested in 2017, it ranks the third worldwide (FAOSTAT, ).…”

Section: Introductionmentioning

confidence: 99%

Dairy dessert processing: Effect of sugar substitution by date syrup and powder on its quality characteristics

Djaoud

Boulekbache‐Makhlouf

Yahia

et al. 2020

J Food Process Preserv

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Second-grade dates can be valorized by its uses in the production of nutritive foods with health benefits. Date syrup (DS), date powder (DP), and their different concentrations, using D-optimal mixture design, were used for the formulation of dairy desserts: syrup dairy dessert (SDD) and mixture dairy dessert (MDD). The optimized mixture proportions of the best dairy dessert formulation, containing date syrup (14%) and powder (2%) as a sugar substitute (0%), were determined to achieve the desired sensory for the effective formulation process. Significant differences in water, protein, fat, and sugar contents were found between SDD, MDD, and commercial dairy dessert (CDD) used as standard, respectively. SDD exhibited the highest total phenolic content (0.65 ± 0.04 mg GAE/g), DPPH inhibition (4.00 ± 0.82%), and reducing power (2.75 ± 0.10%) followed by MDD and CDD. The absence of germs indicated a high microbiological quality of dairy desserts. Rheological measurements revealed that all samples exhibited a weak gel structure and shear thinning behavior. Desserts supplemented with dates led to desserts with an homogeneous structure. Practical applicationsThe evolution of technological processes, conservation techniques, and distribution has led to the development of a wide range of "milks for consumption". The success of these fresh dairy desserts is explained by their beneficial effect on health and organoleptic properties that are appreciated by the consumers. The most delicate in the production of dairy dessert is the development of a "formulation" with the choice of ingredients, and their respective proportion; the amount of sugar, aroma, taste, and color. Phoenix dactylifera L. have a vital therapeutic properties, it represents an inexhaustible source of bioactive compounds such as polyphenols. So the objective of the present study is to formulate new dairy desserts with date syrup and powder (by-products from common date fruits) as a sweetener-ingredient in order to substitute sugars. How to cite this article: Djaoud K, Boulekbache-Makhlouf L, Yahia M, et al. Dairy dessert processing: Effect of sugar substitution by date syrup and powder on its quality characteristics. J Food Process Preserv. 2020;44:e14414.

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Section: Introductionmentioning

confidence: 99%

Dairy dessert processing: Effect of sugar substitution by date syrup and powder on its quality characteristics

Djaoud

Boulekbache‐Makhlouf

Yahia

et al. 2020

J Food Process Preserv

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“…Flavonoids are also emerging to target components of the complex and treatment resistant PDAC TME. Al Alwai et al identify date palm fruit extract to significantly reduce fibrosis of pancreatic stellate cells (PSCs) [4]. As previously mentioned, PSCs play a large role in PDAC progression, metastasis and treatment resistance via the activation of the desmoplastic reaction.…”

Section: Emerging Natural Anticancer Therapiesmentioning

confidence: 99%

“…For example, six FDA approved drugs currently exist derived from animal venom for medical use including ACE inhibitors, antiplatelet drugs, thrombin inhibitors and chronic painkillers [2]. A number of naturally sourced plant compounds have also been utilized, such as anticancer agents, e.g., the mandrake plant (Podophyllum peltatum) is the original source of podophyllotoxin, the active ingredient in etoposide (VP-16) and teniposide (VM-26) [4]. Moreover, a large range of herbal medicines and natural products have been found to inhibit apoptotic resistance in many cancers via different pathways [5] with 60% of today's anticancer drugs originating from natural sources [6].…”

Section: Introductionmentioning

confidence: 99%

Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer

Wishart

Gupta

Nisbet

et al. 2021

Cancers

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The isolation of chemical compounds from natural origins for medical application has played an important role in modern medicine with a range of novel treatments having emerged from various natural forms over the past decades. Natural compounds have been exploited for their antioxidant, antimicrobial and antitumor capabilities. Specifically, 60% of today’s anticancer drugs originate from natural sources. Moreover, the combination of synthetic and natural treatments has shown applications for (i) reduced side effects, (ii) treatment sensitization and (iii) reduction in treatment resistance. This review aims to collate novel and natural compounds that are being explored for their preclinical anticancer, chemosensitizing and radiosensitizing effects on Pancreatic Ductal Adenocarcinoma (PDAC), which is a lethal disease with current treatments being inefficient and causing serve side effects. Two key points are highlighted by this work: (i) the availability of a range of natural compounds for potentially new therapeutic approaches for PDAC, (ii) potential synergetic impact of natural compounds with advanced chemo- and radio-therapeutic modalities for PDAC.

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“…Newman and Cragg estimated that more than 50% of all modern clinical drugs were natural products [ 6 ]. Interestingly, about 49% of cancer drugs discovered from the 1940s to the end of 2014 were of natural sources [ 7 ] such as vinca alkaloids and paclitaxel.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, about 49% of cancer drugs discovered from the 1940s to the end of 2014 were of natural sources [ 7 ] such as vinca alkaloids and paclitaxel. Moreover, etoposide (VP-16) and teniposide (VM-26) are derivatives of podophyllotoxin, isolated from mandrake plant ( Podophyllum peltatum ) [ 6 , 8 ]. Chiliadenus montanus (Vahl.)…”

Section: Introductionmentioning

confidence: 99%

Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies

Elhady

Eltamany

Shaaban

et al. 2020

Plants

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Phytochemical study of Chiliadenus montanus aerial parts afforded six compounds; Intermedeol (1), 5α-hydroperoxy-β-eudesmol (2), 5,7-dihydroxy-3,3’,4’-trimethoxyflavone (3), 5,7,4’-trihydroxy-3,6,3’-trimethoxyflavone (jaceidin) (4), eudesm-11,13-ene-1β,4β,7α-triol (5) and 1β,4β,7β,11-tetrahydroxyeudesmane (6). These compounds were identified based on their NMR spectral data. The isolated compounds were tested for their cytotoxicity against liver cancer cell line (HepG2) and breast cancer cell line (MCF-7). Jaceidin flavonoid (4) exhibited the highest cytotoxic effect in vitro. Therefore, both of jaceidin and C. montanus extract were evaluated for their in vivo anti-tumor activity against Ehrlich’s ascites carcinoma (EAC). Compared to control group, jaceidin and C. montanus extract decreased the tumor weight, improved the histological picture of tumor cells, lowered the levels of VEGF and ameliorate the oxidative stress. Molecular docking and in silico studies suggested that jaceidin was a selective inhibitor of VEGF-mediated angiogenesis with excellent membrane permeability and oral bioavailability.

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Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer

Cited by 34 publications

References 49 publications

Dairy dessert processing: Effect of sugar substitution by date syrup and powder on its quality characteristics

Dairy dessert processing: Effect of sugar substitution by date syrup and powder on its quality characteristics

Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer

Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies

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