Antifungal activity of limonoids from <i>Khaya ivorensis</i>

Abdelgaleil, Samir A. M.; Hashinaga, Fumio; Nakatani, Munehiro

doi:10.1002/ps.978

Cited by 65 publications

(63 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Limonoids obtained from some Khaya species, showed good antibacterial and antifungal activity. 53,54) In another study limonoids from several plants belonging to meliaceae as well as rutaceae family were reported to have significant antifungal activity. 53,55,56) In these studies the importance of structural features on activity is also illustrated.…”

Section: )mentioning

confidence: 99%

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Roy¹,

Saraf

2006

Biological & Pharmaceutical Bulletin

493

276

View full text Add to dashboard Cite

The search for limonoids started long back when scientists started looking for the factor responsible for bitterness in citrus which has negative impact on citrus fruit and juice industry worldwide. The term limonoids was derived from limonin, the first tetranortriterpenoid obtained from citrus bitter principles. Compounds belonging to this group have exhibited a range of biological activities like insecticidal, insect antifeedant and growth regulating activity on insects as well as antibacterial, antifungal, antimalarial, anticancer, antiviral and a number of other pharmacological activities on humans. Although hundreds of limonoids have been isolated from various plants but, their occurrence in the plant kingdom is confined to only plant families of order Rutales and that too more abundantly in Meliaceae and Rutaceae, and less frequently in Cneoraceae and Harrisonia sp. of Simaroubaceae. Limonoids are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. The structural variations of limonoids found in Rutaceae are less than in Meliaceae and are generally limited to the modification of A and B rings, the limonoids of Meliaceae are more complex with very high degree of oxidation and rearrangement exhibited in the parent limonoid structure. To counter the problem of bitterness in citrus juice and products genetic engineering of citrus to maximize the formation of limonoid glucosides for reducing limonoid bitterness is the focus of recent and future research. Regarding the biological activities of limonoids the investigations are to be directed towards detailed characterization, quantification, and designing a simple as well as versatile synthetic route of apparently important limonoids. Extraction methods too should be optimized; evaluation and establishment of pharmaco-dynamic and kinetic principles, and structure activity relationships should be a key goal associated with limonoids so that they can be safely introduced in our arsenal of pharmaceuticals to safeguard the humanity from the wrath of disease and its discomfort.

show abstract

Section: )mentioning

confidence: 99%

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Roy¹,

Saraf

2006

Biological & Pharmaceutical Bulletin

493

276

View full text Add to dashboard Cite

show abstract

“…In Benin, several medicinal plants such as Bridelia ferruginea, Blighia sapida, and Khaya senegalensis are used by women to control the dried yam beetle D. porcellus [2]. In fact, the antifungal [12], antibacterial [13], and insect antifeedant [14] properties of leaf extract of K. senegalensis have been demonstrated. The fruit of ackee (B. sapida) has insecticide properties [15], whereas the antimicrobial properties of leaves and bark extract of B. ferruginea have been proved by Sahu et al [16].…”

Section: Introductionmentioning

confidence: 99%

Repellent Effect and Insecticidal Activities ofBridelia ferruginea,Blighia sapida, andKhaya senegalensisLeaves Powders and Extracts againstDinoderus porcellusin Infested Dried Yam Chips

Loko

Alagbe

Dannon

et al. 2017

Psyche: A Journal of Entomology

View full text Add to dashboard Cite

Dinoderus porcellus is considered as the most important pest of stored yam chips and compounds extracted from plants can be used for its control. The present study aimed to test the insecticidal and repellent activities of powders and extracts of leaves of Bridelia ferruginea, Blighia sapida, and Khaya senegalensis against D. porcellus. The efficacy of plant powders was compared with the synthetic pesticide Antouka (Permethrin 3 g/kg + pirimiphos 16 g/kg). The results of the experiment revealed that all plant powders were effective as repellents. Antouka was more effective as insecticidal than the plant powders and minimal weight loss was observed with B. sapida at 2%. Among treatments, propanol extract of K. senegalensis at 5% was found to elicit the highest repellent effect on D. porcellus. The LC 50 results revealed that the acetone extract of K. senegalensis is the most toxic (0.29 L/insect) to the pest, while the propanol extract of B. ferruginea at 5% exhibited strong fumigant toxicity against D. porcellus, with 88.89% of pest mortality at 160 L/L air. The findings from the current work proved that plant powders and extracts of the three plants are sources of botanical insecticides which may be used in the integrated management of D. porcellus.

show abstract

“…Methyl angolensate and 1,3,7-trideacetylkhivorin displayed the highest antifungal activity against Botrytis cinerea and inhibited 62.8 % and 64.0 % mycelial growth at 1,000 mg/l and 73.3 % and 68.6 % mycelial growth at 1,500 mg/l. 3,7-Dideacetylkhivorin showed stronger antifungal and antibacterial activities than methyl 6-hydroxyangolensate against all of the test fungi and bacteria except Penicillium expansum Link and was reported for the fi rst time (Abdelgaleil et al 2005 ).…”

Section: Limonoidsmentioning

confidence: 98%

Phytochemical Pesticides

Walia¹,

Saha²,

Rana³

2014

Advances in Plant Biopesticides

View full text Add to dashboard Cite

Many phytochemical pesticides exhibiting broad spectrum of activity against pests and diseases have long been considered as attractive alternative to synthetic chemical pesticides as they are biodegradable, target specifi c, and pose no or less hazard to the environment or to human health. Although a large number of studies suggest that plant-based materials do affect arthropod pests, vectors, and other pathogens, yet only a handful of botanicals are currently used in agriculture, and there are few prospects for commercial development of new botanical products. Several factors appear to limit the success of botanicals, most notably regulatory barriers and the availability of competing products of microbial origin that are cost-effective and relatively safe compared with their predecessors. In the context of agricultural pest management, botanical pesticides are best suited for use in organic food production and can play a much greater role in the production and post-harvest protection of food and food products in developing countries. There is thus a need to organize natural sources, develop quality control, adopt standardization strategies, and modify regulatory mechanisms.

show abstract

Antifungal activity of limonoids from Khaya ivorensis

Cited by 65 publications

References 27 publications

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Repellent Effect and Insecticidal Activities ofBridelia ferruginea,Blighia sapida, andKhaya senegalensisLeaves Powders and Extracts againstDinoderus porcellusin Infested Dried Yam Chips

Phytochemical Pesticides

Contact Info

Product

Resources

About