Antifungal potential and biochemical effects of monoterpenes and phenylpropenes on plant

Abstract

Marei G.I.Kh., Abdelgalei S.A.M. (2018): Antifungal potential and biochemical effects of monoterpenes and phenylpropenes on plant pathogenic fungi. Plant Protect. Sci., 54: 9-16.To develop new natural fungicides, six monoterpenes and two phenylpropenes were tested for their antifungal activity against eight plant pathogenic fungi. The results of the mycelial growth inhibition assay showed that trans-cinnamaldehyde was the most potent compound against the eight tested fungi with EC 50 values ranging between 0.75 and 3.19 mg/l. This compound caused the higher mycelial growth inhibition than carbendazim. Furthermore, (-)-menthone exhibited strong antifungal activity against alternaria solani (EC 50 = 9.31 mg/l), Penicillium digitatum (EC 50 = 16.14 mg/l), and rhizoctonia solani (EC 50 = 24.69 mg/l). Likewise, eugenol showed potent antifungal activity against P. digitatum, r. solani, Fusarium solani, and a. solani, whereas EC 50 values were less than 30.0 mg/l. In a separate experiment, trans-cinnamaldehyde, p-cymene, eugenol, and (-)-menthone were evaluated for their inhibitory effects on pectin methyl esterase and cellulase. The tested compounds exhibited the pronounced inhibition of enzyme activities with trans-cinnamaldehyde being the most potent inhibitor for both enzymes.

Ultrasound-Assisted Synthesis, Antifungal Activity against Fusarium oxysporum, and Three-Dimensional Quantitative Structure–Activity Relationship of N,S-Dialkyl Dithiocarbamates Derived from 2-Amino Acids

“…100 μg/mL. 40,41 The present study included two commercial antifungals, that is, mancozeb (a Mn/Zn dithiocarbamate salt) and iprodione (an N -substituted hydantoin carboxamide). The IC 50 values of these antifungals were 0.031 and 0.043 mM, respectively.…”

Future direction of agrochemical development for plant disease in China

“…More recently, studies have identified many novel structures with excellent activity to pathogenic microorganisms, such as caffeic acid, 3,4-dicaffeoylquinic acid, 1,5-dicaffeoylquinic acid, trans-cinnamaldehyde, (-)-menthone, benzofurans, crinipellins, and (+)-yahazunol (Figure 2d) (Chen et al, 2013;Gehan & Samir, 2017;Han et al, 2018;Loiseleur, 2017;Ruiz-Vasquez et al, 2018;Sparks et al, 2017;Zhang, Wang, et al, 2018). Zhang, Wang, et al (2018) developed a scalable method for synthesizing (+)-yahazunol and other related meroterpenoids (Figure 2d, bottom part).…”

Evaluation of Fungistatic Activity of Eight Selected Essential Oils on Four Heterogeneous Fusarium Isolates Obtained from Cereal Grains in Southern Poland

“…According to Cavanagh and Wilkinson [2], Bakkali et al [3], and Sienkiewicz et al [1], the effectiveness of oils is determined by the chemical composition (qualitative and quantitative) of the active substance contained in the oil. High biological activity compounds include the following: terpinene, limonene, germacrene, citronellyl acetate, caryophyllene, thymol, carvacrol, eugenol, eucalyptol, terpineol, and linalool [8][9][10][11].…”

“…Numerous studies showed that EsO exhibit antifungal properties, manifested by inhibition or restriction of mycelium development, inter alia, Fusarium [11][12][13][14]. Fungal growth disorders are caused by changes in the structure of fungi associated with the interaction of EsO on the enzymes responsible for cell wall synthesis.…”