2024
DOI: 10.1002/ange.202405035
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Antigen Delivery Controlled by an On‐Demand Photorelease

Max Löffler,
Stefan Frühschulz,
Zoe Rockel
et al.

Abstract: To eliminate infected and cancerous cells, antigen processing and presentation play a pivotal role through the recognition of antigenic peptides displayed on Major Histocompatibility Complex class I (MHC I) molecules. Here, we developed a photostimulated antigen release system that enables the temporal inception of antigen flux. Simple and effective photocaging of the human immunodeficiency virus (HIV)‐Nef73‐derived epitope, a representative high‐affinity MHC I ligand, was provided by steric hindrance to block… Show more

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