Antigen PR — Another Allele of the HLA—B Locus

Berg‐Loonen, Ella M. van den; Siegers, Hetty; Milde, Joanne; Visser, Ieke; Westera, Ali; Embden, Ellen van; Englefriet, C. P.

doi:10.1111/j.1399-0039.1979.tb00859.x

Cited by 4 publications

(1 citation statement)

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“…Other variants have been described in Malaysians (Joysey et al 1975(Joysey et al , 1977, and further indications of heterogeneity of B15 unassociated with Bw4 or Bw6 were noted in Zambian Blacks by Wolf et al (1975), though only two "B15" sera were available for this Workshop study. Antigens closely related to B15 have also been described in about 1% of Caucasians as "Bu" (Laundy et al 1977(Laundy et al , 1978, "SV" (Schreuder et al 1977) or "PR" (Berg-Loonen et al 1979); in Caucasians and Blacks as Bu or SV (Schreuder et al 1980); and a "Black variant of B15" has been reported as occurring quite commonly in S. African Bantus (Briggs et al 1979).…”

Section: Resultsmentioning

confidence: 99%

B15 Heterogeneity in East African Blacks

Hall¹,

Levin

Entwistle

et al. 1980

Tissue Antigens

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One-hundred-forty-one Blacks (1 35 unrelated) from Kenya and Tanzania have been tissue-typed (HLA-A, B and C loci) as part of a study of host factors involved in Burkitt's lymphoma and naso-pharyngeal carcinoma. Evidence is presented for the existence in this population of several B1S-related antigens which together occur with a relatively high frequency of 30% in unrelated individuals. It is likely that these variants may include the antigens SV and perhaps Bu recently defined with population frequencies of under 1% in Caucasians. In the absence of monospecific typing sera, identification of these variants may be helped by their apparently strong association with C-locus antigens in Blacks. Recognition of these B15 variants has been largely responsible for reducing the proportion of unidentified or "blank" B-locus antigensin this population to only 6%. These findinp substantiate and amplify previous reports suspecting the presence of such antigens in Blacks, and should facilitate studies of possible associations of disease with HLA in these populations.

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Section: Resultsmentioning

confidence: 99%

B15 Heterogeneity in East African Blacks

Hall¹,

Levin

Entwistle

et al. 1980

Tissue Antigens

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Segregation of three recently identified HLA specificities in an American black family

Ward¹,

MacQueen²,

Johnson³

1981

Human Immunology

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Bu and SV: Two Closely Related B‐Locus Specificities

et al. 1980

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The B15/Bw21/Bw35 related specificities 'Bu' and 'SV' have been studied in Bristol and in Leiden, both independently and with mutually exchanged sera and cells. Evidence is presented that these specificities are likely to be discrete though very closely related antigens occurring with a combined phenotype frequency of about 1% in Dutch and English Caucasians. SV may be associated with Aw36, while no clear-cut haplotype or phenotypic association has yet emerged for Bu with any HLA-A or C locus antigen. Bu and SV appear t o be related to the variant of B15 reported to be common in Negroid populations.

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Antigen PR — Another Allele of the HLA—B Locus

Cited by 4 publications

References 1 publication

B15 Heterogeneity in East African Blacks

B15 Heterogeneity in East African Blacks

Segregation of three recently identified HLA specificities in an American black family

Bu and SV: Two Closely Related B‐Locus Specificities

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