Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?

Marelli‐Berg, Federica M.; Jarmin, Sarah J.

doi:10.1016/j.imlet.2004.03.014

Cited by 53 publications

(35 citation statements)

References 55 publications

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“…44 Moreover, it has been recently suggested than ECs themselves play a far more direct role in immunity. 45 Our results indicate that CD40 signaling in ECs leads to transcriptional induction of several immunityrelated molecules and actively contributes to the transformation of ECs to antigen-presenting cells (Document S1, "Immunity"). Thus, CD40-mediated leukocyte-endothelial cell interactions appear to influence immune cell function through antigen presentation and directly affect adaptive immunity, inducing transendothelial migration and/or polarization of different T-cell subsets.…”

Section: Discussionmentioning

confidence: 75%

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling

Pluvinet

Olivar

Krupiński

et al. 2008

Blood

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Section: Discussionmentioning

confidence: 75%

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling

Pluvinet

Olivar

Krupiński

et al. 2008

Blood

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“…This action has been documented in vitro, but whether it occurs in vivo is still debatable, although ECs from different species express various accessory molecules, including CD80, CD86, ICOS-L, programmed death ligand 1, programmed death ligand 2, LFA-3, CD40, and CD134L (40). Therefore, the impact of ECs on adaptive immunity may be exerted through their interaction with leukocytes and platelets.…”

Section: Adaptive Immunitymentioning

confidence: 99%

Immune Regulation by Microvascular Endothelial Cells: Directing Innate and Adaptive Immunity, Coagulation, and Inflammation

Danese¹,

Dejana

Fiocchi

2007

The Journal of Immunology

258

203

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An effective immune response depends not only on the proper activation, regulation, and function of immune cells, but also on their distribution and retention in diverse tissue microenvironments where they encounter a number of stimuli and other cell types. These activities are mediated by endothelial cells, which form specialized microcirculatory networks used by immune cells under both physiological and pathological circumstances. Endothelial cells represent a highly heterogeneous population of cells with the ability to interact with and modulate the function of immune cells. This review is focused on the role of microvascular endothelial cells in innate and adaptive immunity, inflammation, coagulation, angiogenesis, and the therapeutic implications of targeting endothelial cells in selected autoimmune and chronic inflammatory disorders.

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“…With respect to the former, it has become increasingly appreciated that non-hematopoietic peripheral (or 'stromal') APCs play critical, non-redundant roles (i.e., compared to hematopoietic APCs) in shaping adaptive immune responses [16][17][18] . Among such 'semiprofessional' APCs, vascular and lymphatic endothelial cells (which vastly outnumber professional APCs) are among the best appreciated [16][17][18] . However, the details of signaling events and their coupled immunological synapses remain largely uninvestigated.…”

Section: Discussionmentioning

confidence: 99%

“…Though still understudied, vascular and lymphatic endothelial cells are emerging as a large (i.e., greater in numbers than all professional APCs, by ~1,000-fold) peripheral compartment of 'semi-professional' APCs [16][17][18] . These cells express MHC-I-, MHC-II-and a multitude of co-stimulator molecules (e.g., CD40, LFA3, ICOSL, 4-1BB, OX40L, TL1A, PD-L1; but not CD80 and CD86) and are strategically positioned at the blood-tissue interface where they serve specialized sentinel functions [16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

“…These cells express MHC-I-, MHC-II-and a multitude of co-stimulator molecules (e.g., CD40, LFA3, ICOSL, 4-1BB, OX40L, TL1A, PD-L1; but not CD80 and CD86) and are strategically positioned at the blood-tissue interface where they serve specialized sentinel functions [16][17][18] . Previous studies demonstrated that endothelial cells can effectively re-stimulate effector/memory, but not naïve, T cells [19][20][21][22][23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Martinelli

Carman

2015

JoVE

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Adaptive immunity is regulated by dynamic interactions between T cells and antigen presenting cells ('APCs') referred to as 'immunological synapses'. Within these intimate cell-cell interfaces discrete sub-cellular clusters of MHC/Ag-TCR, F-actin, adhesion and signaling molecules form and remodel rapidly. These dynamics are thought to be critical determinants of both the efficiency and quality of the immune responses that develop and therefore of protective versus pathologic immunity. Current understanding of immunological synapses with physiologic APCs is limited by the inadequacy of the obtainable imaging resolution. Though artificial substrate models (e.g., planar lipid bilayers) offer excellent resolution and have been extremely valuable tools, they are inherently non-physiologic and oversimplified. Vascular and lymphatic endothelial cells have emerged as an important peripheral tissue (or stromal) compartment of 'semi-professional APCs'. These APCs (which express most of the molecular machinery of professional APCs) have the unique feature of forming virtually planar cell surface and are readily transfectable (e.g., with fluorescent protein reporters). Herein a basic approach to implement endothelial cells as a novel and physiologic 'planar cellular APC model' for improved imaging and interrogation of fundamental antigenic signaling processes will be described. Video LinkThe video component of this article can be found at

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Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?

Cited by 53 publications

References 55 publications

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling

CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling

Immune Regulation by Microvascular Endothelial Cells: Directing Innate and Adaptive Immunity, Coagulation, and Inflammation

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

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