Antigen presenting cells in mucosal sites of veterinary species

Haverson, Karin; Riffault, Sabine

doi:10.1051/vetres:2006005

Cited by 18 publications

(16 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD14 can also be found on monocyteand bone marrow-derived GM-CSF-driven DC, although functional differences are found when compared to monocyte CD14. Furthermore, the continued presence of CD14 and CD16 [87] on mature and immature porcine DC was a notable difference with other species including humans [46].…”

Section: Cd14mentioning

confidence: 86%

“…All blood monocytes and all NK lymphocytes bear CD16 [185,232]. This receptor is also found on immature and mature monocyte-derived DC as well as on blood DC in pigs, contrasting to the human expression pattern [46] and in gut DC [87].…”

Section: Cd16mentioning

confidence: 99%

“…Consequently, the molecule recognised by the cross-reactive anti-hCD11b was named wCD11R1. A recent study using the cannulated pseudo-afferent lymph model, has demonstrated that large numbers of DC, expressing CD11R1 (CD11b) and CD172 are found in efferent lymph [21] and are phenotypically similar to DC from the diffuse lymphoid tissue [21,87].…”

Section: The 2 Integrin Subfamily Cd11a-c/cd18mentioning

confidence: 99%

See 2 more Smart Citations

Membrane markers of the immune cells in swine: an update

Piriou-Guzylack¹,

2008

View full text Add to dashboard Cite

-Besides their breeding value, swine are increasingly used as biomedical models. As reported in three international swine clusters of differentiation (CD) workshops and in the animal homologue section of the last workshop for the determination of human leukocyte differentiation antigens (HLDA 8), characterisation of leukocyte surface antigens by monoclonal antibodies and other molecular studies have determined the cell lineages and blood leukocyte subsets implicated in the immune response, including cell adhesion molecules involved in cell trafficking. This review focusses on the current state of knowledge of porcine leukocyte differentiation and major histocompatibility complex (SLA) molecules. Examples of porcine particularities such as the double-positive T lymphocytes with the phenotype CD4 + CD8 low and CD4 − CD8 low T cell subsets and the persistence of SLA class II after T-lymphocyte activation are illustrated, as well as the shared characteristics of the Artiodactyla group, such as the high proportion of TcR (T cell receptor) T cells in blood and other lymphoid tissues. Furthermore, discrepancies between swine and humans, such as CD16 expression on dendritic cells and CD11b (wCD11R1) tissue distribution are outlined. The rapidly growing information should facilitate manipulation of the swine immune system towards improving disease control, and open new avenues for biomedical research using the pig as a model. cluster of differentiation (CD) / monoclonal antibody / immune system / histocompatibility system / pig

show abstract

Section: Cd14mentioning

confidence: 86%

Section: Cd16mentioning

confidence: 99%

Section: The 2 Integrin Subfamily Cd11a-c/cd18mentioning

confidence: 99%

See 1 more Smart Citation

Membrane markers of the immune cells in swine: an update

Piriou-Guzylack¹,

2008

View full text Add to dashboard Cite

show abstract

“…Antigen-presenting cells expressing MHC II are present in large numbers in the lamina propria of many species. In adult pigs, they have been characterised as functional, immature, dendritic cells [26], which are described in more detail in a review article in this issue by Haverson and Riffault [24]. These dendritic cells are present in large numbers within the villi and co-localise with T-cells expressing the CD4 co-receptor in the pig.…”

Section: Diffuse Gut-associated Lymphoid Tissue In Adultsmentioning

confidence: 99%

The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals

Bailey

Haverson²

2006

Vet. Res.

Self Cite

View full text Add to dashboard Cite

-The mucosal immune system is exposed to a range of antigens associated with pathogens, to which it must mount active immune responses. However, it is also exposed to a large number of harmless antigens associated with food and with commensal microbial flora, to which expression of active, inflammatory immune responses to these antigens is undesirable. The mucosal immune system must contain machinery capable of evaluating the antigens to which it is exposed and mounting appropriate effector or regulatory responses. Since the immune system is likely to have evolved initially in mucosal tissues, the requirement to prevent damaging allergic responses must be at least as old as the adaptive immune system, and studies of the mechanisms should include a range of non-mammalian species. Despite the importance for rational design of vaccines and for control of allergic reactions, the mechanisms involved are still largely unclear. It is not clear that the classical experimental protocol of "oral tolerance" is, in fact, measuring a biologically important phenomenon, nor is it clear whether tolerance is regulated in the evolutionarily recent organised lymphoid tissue (the lymph nodes) or the more ancient, diffuse architecture in the intestine. The capacity of the immune system to discriminate between "dangerous" and "harmless" antigens appears to develop with age and exposure to microbial flora. Thus, the ability of an individual or a group of animals to correctly regulate mucosal immune responses will depend on age, genetics and on their microbial environment and history. Attempts to manipulate the mucosal immune system towards active immune responses by oral vaccines, or towards oral tolerance, are likely to be confounded by environmentally-induced variability between individuals and between groups of animals.

show abstract

“…DCs in the small-intestinal lamina propria were found to express CX 3 CR1 (Niess et al, 2005 (Stokes & Bailey, 2000). Haverson & Riffault (2006) found that CD45 + population was potent stimulators of primary responses, but CD45 -stromal population were unable to generate any proliferative response. Further, there are identified some unusual APC DC such as expressing both CD11c and MHC II at low intensity.…”

Section: The Role Of Antigen Presenting Dendritic Cellsmentioning

confidence: 98%