Antigen‐Presenting Cells Including Langerhans Cells, Veiled Cells and Interdigitating Cells

Balfour, Brigid M.; Drexhage, H. A.; Kamperdijk, E. W. A.; Hoefsmit, E. C. M.

doi:10.1002/9780470720660.ch15

Cited by 55 publications

(6 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differential interference contrast imaging showed the KUL01 +ve cells to be macrophage-like, with condensed cytoplasm. The KUL01 −ve cells had more expanded cytoplasm with the appearance of veiled cells [25]. DEC205 expression was upregulated following LPS stimulation, particularly with respect to a vesicular compartment that may represent early endosomes (Figure 8A,B).…”

Section: Resultsmentioning

confidence: 97%

Expression of Chicken DEC205 Reflects the Unique Structure and Function of the Avian Immune System

2013

View full text Add to dashboard Cite

The generation of appropriate adaptive immune responses relies critically on dendritic cells, about which relatively little is known in chickens, a vital livestock species, in comparison with man and mouse. We cloned and sequenced chicken DEC205 cDNA and used this knowledge to produce quantitative PCR assays and monoclonal antibodies to study expression of DEC205 as well as CD83. The gene structure of DEC205 was identical to those of other species. Transcripts of both genes were found at higher levels in lymphoid tissues and the expression of DEC205 in normal birds had a characteristic distribution in the primary lymphoid organs. In spleen, DEC205 was seen on cells ideally located to trap antigen. In thymus it was found on cells thought to participate in the education of T cells, and in the bursa on cells that may be involved in presentation of antigen to B cells and regulation of B cell migration. The expression of DEC205 on cells other than antigen presenting cells (APC) is also described. Isolated splenocytes strongly expressing DEC205 but not the KUL01 antigen have morphology similar to mammalian dendritic cells and the distinct expression of DEC205 within the avian-specific Bursa of Fabricius alludes to a unique function in this organ of B cell diversification.

show abstract

Section: Resultsmentioning

confidence: 97%

Expression of Chicken DEC205 Reflects the Unique Structure and Function of the Avian Immune System

2013

View full text Add to dashboard Cite

show abstract

“…This information is transmitted by “veiled” MDC, a subpopulation of tissue MDC. They are HLA-DR positive, highly immunogenic and present antigens to T cells in the draining lymph nodes [146-149]. …”

Section: Developmental Immune Adaptation and Determination Of The mentioning

confidence: 99%

Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Bukovský

Caudle

2012

Reprod Biol Endocrinol

View full text Add to dashboard Cite

The immune system plays an important role in the regulation of tissue homeostasis ("tissue immune physiology"). Function of distinct tissues during adulthood, including the ovary, requires (1) Renewal from stem cells, (2) Preservation of tissue-specific cells in a proper differentiated state, which differs among distinct tissues, and (3) Regulation of tissue quantity. Such morphostasis can be executed by the tissue control system, consisting of immune system-related components, vascular pericytes, and autonomic innervation. Morphostasis is established epigenetically, during morphogenetic (developmental) immune adaptation, i.e., during the critical developmental period. Subsequently, the tissues are maintained in a state of differentiation reached during the adaptation by a “stop effect” of resident and self renewing monocyte-derived cells. The later normal tissue is programmed to emerge (e.g., late emergence of ovarian granulosa cells), the earlier its function ceases. Alteration of certain tissue differentiation during the critical developmental period causes persistent alteration of that tissue function, including premature ovarian failure (POF) and primary amenorrhea. In fetal and adult human ovaries the ovarian surface epithelium cells called ovarian stem cells (OSC) are bipotent stem cells for the formation of ovarian germ and granulosa cells. Recently termed oogonial stem cells are, in reality, not stem but already germ cells which have the ability to divide. Immune system-related cells and molecules accompany asymmetric division of OSC resulting in the emergence of secondary germ cells, symmetric division, and migration of secondary germ cells, formation of new granulosa cells and fetal and adult primordial follicles (follicular renewal), and selection and growth of primary/preantral, and dominant follicles. The number of selected follicles during each ovarian cycle is determined by autonomic innervation. Morphostasis is altered with advancing age, due to degenerative changes of the immune system. This causes cessation of oocyte and follicular renewal at 38 +/-2 years of age due to the lack of formation of new granulosa cells. Oocytes in primordial follicles persisting after the end of the prime reproductive period accumulate genetic alterations resulting in an exponentially growing incidence of fetal trisomies and other genetic abnormalities with advanced maternal age. The secondary germ cells also develop in the OSC cultures derived from POF and aging ovaries. In vitro conditions are free of immune mechanisms, which prevent neo-oogenesis in vivo. Such germ cells are capable of differentiating in vitro into functional oocytes. This may provide fresh oocytes and genetically related children to women lacking the ability to produce their own follicular oocytes. Further study of "immune physiology" may help us to better understand ovarian physiology and pathology, including ovarian infertility caused by POF or by a lack of ovarian follicles with functional oocytes in aging ovaries. The observations indicating...

show abstract

“…It is now recognized that the macrophage family of cells is heterogeneous. Morphological and functional distinctions have been made between 'classic' phagocytic macrophages and populations of dendritic cells that are poorly phagocytic if at all, and may represent specialized antigenpresenting cells [2,10]. These dendritic cells were originally isolated from murine spleen [23], hut similar cells can be identified in man.…”

Section: W Poulter Department Of Immunology Royal Free Hospitalmentioning

confidence: 99%

“…These dendritic cells were originally isolated from murine spleen [23], hut similar cells can be identified in man. They have been variously described as interdigitating cells [10], veiled cells [2], or collectively as dendritic cells [20]. Included in this latter group are the Langerhans' cells of the epidermis [21].…”

Section: W Poulter Department Of Immunology Royal Free Hospitalmentioning

confidence: 99%

Discrimination of Human Macrophages and Dendritic Cells by Means of Monoclonal Antibodies

et al. 1986

View full text Add to dashboard Cite

Two monoclonal antibodies (MoAb), RFD1 and RFD7, have been used to investigate whether human macrophages and dendritic cells represent phenotypically distinct cell types. RFD7 recognizes a 77 kd antigen, and is specific for acid phosphatase positive tissue macrophages, while RFD1 recognizes a unique Class II antigen, which is associated with dendritic cells. With immunohistological/cytological methods it was found that neither of these reagents reacted with granulocytes, monocytes, or lymphocytes, with the exception that a small proportion (<20%) of B cells were stained with RFD1. In tissues, RFD7 reacted with mature macrophages only and did not stain Langerhans cells in the skin or the interdigitating (dendritic) cells of the T‐cell zones of lymphoid tissue and the thymic medulla. Conversely, RFD1 appeared specific for the interdigitating (dendritic) cells and did not react with macrophage populations identified morphologically, geographically, and histochemically in any tissue studied. When peripheral blood monocytes (RFD1−, RFD7−) were matured in vitro, two distinct populations of RFD1+ RFD7− and RFD7+ RFD1− cells emerged. It is concluded that in normal tissues these two reagents identify phenotypic differences between macrophages and dendritic cells that may have functional significance.

show abstract

Antigen‐Presenting Cells Including Langerhans Cells, Veiled Cells and Interdigitating Cells

Cited by 55 publications

References 71 publications

Expression of Chicken DEC205 Reflects the Unique Structure and Function of the Avian Immune System

Expression of Chicken DEC205 Reflects the Unique Structure and Function of the Avian Immune System

Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Discrimination of Human Macrophages and Dendritic Cells by Means of Monoclonal Antibodies

Contact Info

Product

Resources

About