Antigen Specific T Cell Factors in the Genetic Control of the Immune Response to Poly(Tyr, Glu)-Poly(Pro)—Poly(Lys)

Mozes, Edna; Isac, Ronit

doi:10.1007/978-1-4613-4355-4_85

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…Together with experiments of Mozes and collaborators (11)(12)(13) with the branched copolymers, our studies on the process(es) controlled by Ir genes in the GAT system indicate that the genetic defect can be expressed in T cells and B cells or only in B cells. In their studies of the response to (T,G)-A--L, Mozes et al ., (11,12) found that thymocytes from low responder C3H/HeJ (H-2k) mice and those from high responder C3H.SW (H-2b) mice educated to (T,G)-A--L produce an antigen-specific factor capable of cooperating with responder (H-2°) but not nonresponder (H-2'p) bone marrow cells in vivo .…”

Section: Discussionmentioning

confidence: 45%

“…This suggests that the low responder C3H/HeJ mice fail to produce high levels of antibody to (T,G)-A--L because of a defect in the capacity of B cells to receive a T-cell signal rather than a failure of their T cells to respond to (T,G)-A--L . In contrast, thymocytes from the low responder SJL (H-2s) mice did not elaborate a (T,G)-A--L specific factor nor did their B cells produce (T,G)-A--L-specific antibody when mixed with a specific responder thymocyte factor, indicating a defect in both cell types (13) .…”

Section: Discussionmentioning

confidence: 94%

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Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.

Kapp¹,

Pierce²,

Benacerraf³

1975

The Journal of Experimental Medicine

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Mice which are genetic nonresponders to the random terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) not only fail to develop GAT-specific antibody responses when stimulated with soluble GAT either in vivo or in vitro, but develop GAT-specific T cells which suppress the GAT-specific plaque-forming cell response of normal nonresponder mice stimulated with GAT complexed to methylated bovine serum albumin (MBSA).Thus, both responder and nonresponder mice have T cells which recognize GAT. However, nonresponder mice can develop GAT-specific helper T cells if immunized with GAT bound to MBSA or to macrophages. The relevance of Ir gene-controlled responses is discussed.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 94%

Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.

Kapp¹,

Pierce²,

Benacerraf³

1975

The Journal of Experimental Medicine

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“…Two types of helper factors (Fig. The data available suggest that the T~F is directly adsorbed by and acts on T cells, while for THF, either M e T~F [32,34,52,53,55,57,73,93,95,96,[139][140][141][142]. Only one report details TaF, which has as its target another T cell, which in turn appears to act as the T~ for the B cell response [149].…”

Section: B Functional Analysis Of Factor Activitymentioning

confidence: 99%

Helper and suppressor T cell factors

Germain

Benacerraf

1980

Springer Semin Immunopathol

115

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I. IntroductionThe emerging view of the immune system is that of a collection of lymphocyte networks, in which the cellular elements are related by a c o m m o n set of antigen reactivities or the possession of a distinct subset of antigen receptors [14,28,59]. Each network involves two separate components, the first responsible for effector function, and the second consisting of the regulatory apparatus for controlling the effector activity. Over the past few years, great strides have been made in identifying the cells involved in immune regulation. It is clear that T lymphocytes play a crucial role in this process, and can be divided generally according to whether their activity is to amplify overall effector function, or to dampen (suppress) immunity. T cell subsets with distinct differentiation (cell surface) markers, tissue localization, drug sensitivities, and lifetimes have been found to mediate these various effects [15,16,45,47]. In addition, there is growing evidence that the regulatory capacity of these T Abbreviations: ABA azobenzenearsonate; BGG bovine gamma globulin; C complement; C G A T common idiotype of anti-GAT antibodies; C~ constant region of immunoglobulin heavy chain; C L constant region of immunoglobulin light chain; CRI cross-reactive idiotype of anti-ABA antibodies of A/J mice; CTLcytolytic T lymphocytes; DNP dinitrophenyl; EA egg albumin; GA random copolymer of L-glutamic acid6°-L-alanine4°; GATrandom copolymer of L-glutamic acid6°-L-alanine3°-L-tyrosinel°; GLO random copolymer of L-glutamic acid56-L-lysine35-L-phenylalanine9; GT random copolymer of L-glutamic acidS°-L-tyrosineS°; HTG human gamma globulin; K L H keyhole limpet hemocyanin; MBSA methylated bovine serum albumin; M H C major histocompatibility complex; M L R mixed lymphocyte response; M0 macrophage(s); OX oxazalone; PC1 picryl chloride = trinitrochlorobenzene; PEC peritoneal exudate cells; PFC plaque forming cells; (Phe, G)-Aderived helper factor; T s suppressor T lymphocyte; TsF T cell derived suppressor factor; Ts~ suppressor T lymphocyte induced by TsF; V H variable region of the heavy chain of immunoglobulin; X R X-irradiated;

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“…At the time complementation was described in the GL~ system, Munro and Taussig [66] and Mozes et al [65] presented evidence for gene complementation in another Ir gene system. These investigators analysed the immune response to the branched synthetic polymer (T,G)-A--L. They provided evidence that the genetic defects controlled by each of the complementing Ir-(T,G)-A--L genes resided in different cellular populations.…”

Section: Are the Ir-gkb-e And Ir-glq)-fl Loci Expressed In Different mentioning

confidence: 99%

Complementation of H-2-linked genes controlling immune responsiveness

Dorf

1978

Springer Semin Immunopathol

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Antigen Specific T Cell Factors in the Genetic Control of the Immune Response to Poly(Tyr, Glu)-Poly(Pro)—Poly(Lys)

Cited by 9 publications

References 6 publications

Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.

Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.

Helper and suppressor T cell factors

Complementation of H-2-linked genes controlling immune responsiveness

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