2014
DOI: 10.1111/cei.12364
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Antigen-triggered interferon-γ and interleukin-10 pattern in cured mucosal leishmaniasis patients is shaped during the active phase of disease

Abstract: An exacerbated type 1 response to leishmanial antigens is the basis of tissue destruction observed in mucosal leishmaniasis (ML). After therapy, a persistent production of high levels of inflammatory cytokines can confer a poor prognosis. Herein we investigated whether the clinical conditions defined during the active phase of ML affect the magnitude of long-term anti-Leishmania immune response. Twenty clinically cured ML cases were studied. Peripheral blood mononuclear cells (PBMC) were cultured with L. brazi… Show more

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Cited by 11 publications
(6 citation statements)
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“…Our results show that the pro-inflammatory pattern of majority production of IL-1β, IL-6, and TNF in our relapsed patients remains, although at lower levels, in the cured group. Similar results were also observed in a recent study using the same standard ratio between production of pro-and anti-inflammatory cytokines in patients with mucosal leishmaniasis and individuals post leishmaniasis treatment [ 38 ].…”
Section: Discussionsupporting
confidence: 89%
“…Our results show that the pro-inflammatory pattern of majority production of IL-1β, IL-6, and TNF in our relapsed patients remains, although at lower levels, in the cured group. Similar results were also observed in a recent study using the same standard ratio between production of pro-and anti-inflammatory cytokines in patients with mucosal leishmaniasis and individuals post leishmaniasis treatment [ 38 ].…”
Section: Discussionsupporting
confidence: 89%
“…The delayed development of a protective immune response may facilitate parasite dissemination, and chronic systemic exposure to Leishmania antigens could in turn lead to the exacerbated inflammatory immune response associated with mucosal disease. This idea is in accordance with the finding that in cured ML patients, the duration of active disease is positively associated with antigen-induced production of IFN-g but negatively associated with IL-10 production (Nogueira et al, 2014).…”
Section: Discussionsupporting
confidence: 91%
“…In fact, a decrease in IFN-γ, IL-5 and TNF-α in both groups was seen at day 28 post treatment with meglumine antimoniate in a previous study [ 49 ]. These results indicate that proinflammatory responses were progressively downmodulated after therapy and that the cytokine profile produced after cure is shaped during the active phase of disease [ 50 ].…”
Section: Discussionmentioning
confidence: 99%