Antigingivitis and Antiplaque Effects of Oral Probiotic Containing the Streptococcus salivarius M18 Strain: A Randomized Clinical Trial

Babina, Ksenia; Salikhova, Dilara; Doroshina, Vladlena; Makeeva, Irina; Zaytsev, Alexandr; Uvarichev, Matvey; Polyakova, Maria; Novozhilova, Nina

doi:10.3390/nu15183882

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…There is some evidence that topical probiotics may increase salivary flow rate [97,98]. Also, probiotics have been reported to decrease plaque formation [99][100][101][102][103][104].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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Soft drinks may have a deleterious effect on dental health due to a high titratable acidity and a low pH that could be sufficient to induce tooth demineralization. The use of oral care products immediately after acidic challenge may diminish the erosive potential of soft drinks. We assessed the effect of oral care foams and a spray on salivary pH changes after exposure to Coca-Cola® in young adults. Thirty-three consenting eligible patients were recruited in this double-blind, randomized, crossover study performed in six visits. Baseline examination included unstimulated salivary flow rate, stimulated salivary buffer capacity, and the simplified oral hygiene index (OHI-S) assessment. Salivary pH and time for pH recovery were registered after exposure to Coca-Cola® alone or that followed by the application of each of the studied products (an oral foam containing hydroxyapatite and probiotics, an oral foam containing amino fluoride, an alkaline oral spray, and tap water). Thirty-two patients completed the entire study protocol and were included in the final analysis. The mean minimum salivary pH and the mean oral clearance rate after rinsing with Coca-Cola® were 6.3 and 27 min, respectively. Further rinsing with any one of the tested solutions, including tap water, resulted in a significant improvement in these parameters. When the pH curves were plotted, the oral care products demonstrated a lower area under the curve that differed significantly from the area under the curve for Coca-Cola®; tap water did not differ significantly from Coca-Cola® and oral care products. Minimum salivary pH correlated positively with salivary buffer capacity and salivation rate, while salivary clearance correlated with OHI-S plaque scores. In conclusion, the effect of oral care foams and a spray on minimum salivary pH and salivary clearance after exposure to Coca-Cola® did not differ significantly among the tested products and tap water. Trial registration NCT06148662. Funding: none.

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“…There is some evidence that topical probiotics may increase salivary flow rate [97,98]. Also, probiotics have been reported to decrease plaque formation [99][100][101][102][103][104].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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“…Probiotics may have three potential roles in dental practices: (1) the prevention of antibiotic-associated complications, (2) prevention of dental caries, or (3) treatment of periodontal disease. The interest in probiotics in dental practices has been growing, but there is no current consensus on how probiotics can best be utilized ( 6 , 7 ). Our aims are to discuss the role of probiotics when used to limit complications of antibiotics and to prevent or treat dental infections.…”

Section: Introductionmentioning

confidence: 99%

The dual role for probiotics use in dental practices

Goff,

McFarland,

Johnson

et al. 2023

Front. Oral. Health

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Specific Synbiotic Sugars Stimulate Streptococcus salivarius BLIS K12 and BLIS M18 Lantibiotic Production to Expand Bacterial Inhibition Range and Potency

Harold,

Jones,

Barber

et al. 2024

Applied Microbiology

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Synbiotics are mixtures of prebiotics and probiotics that enhance the activity of probiotic bacteria when co-administered to provide greater benefits to the host. Traditionally, the synbiotics that have been discovered enhance gut probiotic strains and are nutritionally complex molecules that survive digestive breakdown until they reach the later stages of the intestinal tract. Here, we screened and identified sugars or sugar substitutes as synbiotics for the oral probiotic strains Streptococcus salivarius BLIS K12 and BLIS M18. Using a modified deferred antagonism assay, we found that 0.5% (w/v) galactose and 2.5% (w/v) raffinose were the best candidates for use as synbiotics with BLIS K12 and M18, as they trigger enhanced antimicrobial activity against a range of bacteria representing species from the mouth, gut, and skin. Using reverse transcriptase quantitative PCR, we found that this enhanced antimicrobial activity was caused by the upregulation of the lantibiotic genes salA, salB, and sal9 in either K12 or M18. This led to the conclusion that either 2.5% (w/v) raffinose or 0.5% (w/v) galactose, respectively, are suitable synbiotics for use in conjunction with BLIS K12 and M18 to enhance probiotic performance.

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Antigingivitis and Antiplaque Effects of Oral Probiotic Containing the Streptococcus salivarius M18 Strain: A Randomized Clinical Trial

Cited by 4 publications

References 68 publications

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

The dual role for probiotics use in dental practices

Specific Synbiotic Sugars Stimulate Streptococcus salivarius BLIS K12 and BLIS M18 Lantibiotic Production to Expand Bacterial Inhibition Range and Potency

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