Antihistamines in Hydrops Fœtalis

Biermé, S; Biermé, R

doi:10.1016/s0140-6736(67)92152-6

Cited by 9 publications

(3 citation statements)

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“…Random field. We consider random fields defined on a space of measures, in the same spirit as the random functionals of [13] or the generalized random fields of [3]. Let M denote the space of signed measures µ on R d with finite total variation |µ|(R d ) < ∞, where |µ| is the total variation measure of µ.…”

Section: Settingmentioning

confidence: 99%

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Self-similar Random Fields and Rescaled Random Balls Models

2009

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Abstract. We study generalized random fields which arise as rescaling limits of spatial configurations of uniformly scattered random balls as the mean radius of the balls tends to 0 or infinity. Assuming that the radius distribution has a power law behavior, we prove that the centered and re-normalized random balls field admits a limit with spatial dependence and self-similarity properties. In particular, our approach provides a unified framework to obtain all self-similar, translation and rotation invariant Gaussian fields. Under specific assumptions, we also get a Poisson type asymptotic field. In addition to investigating stationarity and self-similarity properties, we give L2-representations of the asymptotic generalized random fields viewed as continuous random linear functionals.

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Section: Settingmentioning

confidence: 99%

“…We will use the representation of generalized random fields as defined by Matheron [16], to provide an answer (see also the links between "generalized random fields" and "punctual random fields" in [3]). …”

Section: 2mentioning

confidence: 99%

Self-similar Random Fields and Rescaled Random Balls Models

2009

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“…Since the phenothiazine drugs are placenta permeable their administration during pregnancy in the case of foeto-maternal incompatibilities may help to lessen erythroblastosis at least when it is due to immune anti-A or anti-B antibodies. Bierme & Bierme (1967) observed that administration of promethazine in conjunction with intraperitoneal transfusions proved of benefit in cases of rhesus immunization. However promethazine in vitro has proved much less effective in inhibiting red cell agglutination due to Rh antibodies than that observed with the ABO system (unpublished observations).…”

Section: Discussionmentioning

confidence: 99%

Effects of some phenothiazines, tricyclic antidepressants and antihistamines on red cell agglutination

Tait

1970

Journal of Pharmacy and Pharmacology

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The observation that promethazine hydrochloride inhibited red cell agglutination in the ABO blood group system led to the screening of a series of drugs structurally related to promethazine in an attempt to establish a structure activity relation. Standard group 0 serum agglutinated group A and group B cells. The serum in each test was pretreated with drug and the degree of agglutination on the slide was assessed by both direct and microscopic means. All phenothiazines tested possessed this property except thiopropazate and the cyclic compound M0967C. Several tricyclic antidepressants and antihistamines tested possessed inhibitory activity, the tricyclic compounds were generally as active as the phenothiazines but the antihistamines varied in activity. The structure associated with maximum activity appeared to be a mono-or di-methyl substituted ethylamine or propylamine chain. However, the presence of the phenothiazine nucleus seems to strengthen activity suggesting that the overall shape of the molecule is important. Within the phenothiazine group there appeared to be a relation between basicity and inhibitory activity. It is suggested that the positively charged drug molecules in solution are attracted to the negative acidic groups on the red cell membrane thus inhibiting the formation of antibody-antigen complexes. The cyclization of the phenothiazine and the tricyclic compounds' sidechain appears to abolish the inhibitory action. These findings may be of clinical importance with respect to ABO incompatibilities between mother and foetus and also in laboratory serum antibody studies.Promethazine inhibits agglutination in the ABO blood group system (Tait, 1968). This finding led to the investigation of other drugs having chemical structures or pharmacological activities related to those of promethazine, to determine the extent to which these factors were related to inhibition of red cell agglutination. EXPERIMENTALCommercial preparations of human group A and group B cells suspended in a medium including inosine and disodium EDTA were supplied by the Ortho Pharmaceutical Company. Aliquots of suspensions of group A or group B cells were mixed separately on a slide with equal volumes of incompatible group 0 serum containing concentrations of drugs ranging from 5 x 10-l' to 5 x 1 0 -2~. One drop each of the cell suspension and of the treated serum were delivered from standardized pipettes. The rate and degree of agglutination were assessed by direct inspection and by microscopic examination of the mixtures on the slide, and were compared with control samples in which the drug solution was replaced by an equal volume of

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Über die lokale Einwirkung von Sedativa und Prednisolonsuccinat auf die osmotische und die Immun-Hämolyse

Bube

Sehrbundt

1972

Blut

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Antihistamines in Hydrops Fœtalis

Cited by 9 publications

References 1 publication

Self-similar Random Fields and Rescaled Random Balls Models

Self-similar Random Fields and Rescaled Random Balls Models

Effects of some phenothiazines, tricyclic antidepressants and antihistamines on red cell agglutination

Über die lokale Einwirkung von Sedativa und Prednisolonsuccinat auf die osmotische und die Immun-Hämolyse

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