Antihyperglycemia activity of self-nano emulsifying drug-delivery systems (SNEDDS) of Ipomoea reptans, Poir leaf ethanolic extract in zebrafish (Danio rerio)

Hayati, Farida; Chabib, Lutfi; Darma, Diah Dwi

doi:10.1063/1.5064986

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…A comparison with free extract was not performed. Similar results were obtained by the same author using Ipomoea reptans ethanolic extract-SNEDDSs [ 230 ].…”

Section: Current Lipid- and Inorganic-based (Metal Or Metal Oxide) Na...supporting

confidence: 89%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

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“…A comparison with free extract was not performed. Similar results were obtained by the same author using Ipomoea reptans ethanolic extract-SNEDDSs [ 230 ].…”

Section: Current Lipid- and Inorganic-based (Metal Or Metal Oxide) Na...supporting

confidence: 89%

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

et al. 2022

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“…reptans extract was prepared as a nano-emulsifying drug and showed antihyperglycemic activity using the zebrafish (Danio rerio) model (Hayati et al, 2018). The present study sought to investigate antioxidant activity and possible inhibition on α-glucosidase, lipase, and trypsin by I. reptans leaves and its fractions in several solvent systems using in vitro methods.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antidiabetic, and Anti-obesity Potential of Ipomoea reptans Poir Leaves

et al. 2020

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Ipomoea reptans Poir or kangkung is a popular leafy vegetable, a favorite to people in Asian countries. However, limited information is available on their bioactivities. In the present study, the antioxidant, antidiabetic, and anti-obesity potential of I. reptans leaves were investigated. Different fractions (ethanol, ethyl acetate, and hexane) of I. reptans leaves were evaluated for their scavenging activity on DPPH radicals, whereas their reducing potential was investigated by cupric reducing antioxidant capacity (CuPRAC), total antioxidant, and reducing power assays. The antidiabetic potential was investigated by their inhibition effect on a-glucosidase. Total phenolic and flavonoid contents of I. reptans leaves were solvent dependent. Ethyl acetate contained the highest phenolic content, followed by ethanol and hexane fractions. However, for flavonoid content, the order was ethanol > ethyl acetate > hexane. All fractions showed DPPH scavenging activity in a concentration-dependent manner, with activities weaker than standards ascorbic acid and BHT, in the order of ethanol > ethyl acetate > hexane. All fractions showed reducing capacity, but only hexane and ethanol fractions of I. reptans leaves showed inhibition on a-glucosidase, with hexane showed more potent inhibition compared to acarbose. The study also found that fractions of I. reptans inhibit lipase and trypsin, enzymes related to lipid metabolism. Findings in this study offer a prospect for I. reptans leaves as a functional food source for antioxidant, antidiabetic, and anti-obesity purposes.

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“…SNEDDS is an alternative nanoparticle preparation that has been widely studied and proven to increase the effectiveness of research on natural ingredients. [ 18 19 ] One of the components suspected of having potential toxicity is capryol. [ 20 ] In fact, a nanocompound with a size <200 µg is able to penetrate into the chorion, thus affecting the growth of zebrafish embryos.…”

Section: Discussionmentioning

confidence: 99%

Effects of pegagan (Centella asiatica L.) ethanolic extract SNEDDS (self-nanoemulsifying drug delivery systems) on the development of zebrafish (Danio rerio) Embryos

Hayati

Chabib

et al. 2020

J Pharm Bioall Sci

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A BSTRACT Introduction: Pegagan is a traditional medicinal plant with three major bioactive properties, triterpenoid, steroids, and saponin. It has the properties of antioxidant, antistress, and wound healing. Pegagan extract is prepared in self-nanoemulsifying drug delivery systems (SNEDDS) to overcome the problem of low water-solubility level. Objectives: This study aimed to observe the effect of pegagan ethanolic extract SNEDDS on the development of zebrafish embryos. Materials and Methods: This study used 12 sets of zebrafish embryos presented in five sets of extract SNEDDS with different concentrations, that is, 20, 10, 5, 2.5, and 1.25 μg, five sets of SNEDDS without extract with different concentrations, that is, 20, 10, 5, 2.5, and 1.25 μg, a set of positive control (3.4-DCA 4 mg/L) with one control set (diluted with water), and a negative control (SNEDDS without extract). The procedure was conducted for 96 h with observations every 24 h. The parameters observed were embryonic coagulation, formation of somites, detachment of tail bud from the yolk, and abnormality of embryo Results: The results showed that in 96 h the 20ppm concentration caused 100% mortality. Embryo abnormality appeared as coagulation of embryo, somite malformation, and abnormal tail. Discussion: There is a correlation between the concentration of SNEDDS and the incidence of embryo coagulation. The malformation in the group of pegagan extract SNEDDS is characterized by cardiac edema, somite malformation, and abnormal tail. Conclusion: Pegagan ethanolic extract SNEDDS of 20ppm can inhibit the development of zebrafish embryos.

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Antihyperglycemia activity of self-nano emulsifying drug-delivery systems (SNEDDS) of Ipomoea reptans, Poir leaf ethanolic extract in zebrafish (Danio rerio)

Cited by 8 publications

References 9 publications

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations

Antioxidant, Antidiabetic, and Anti-obesity Potential of Ipomoea reptans Poir Leaves

Effects of pegagan (Centella asiatica L.) ethanolic extract SNEDDS (self-nanoemulsifying drug delivery systems) on the development of zebrafish (Danio rerio) Embryos

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